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41.
针对工件同时具有学习和退化效应、机器具有可用性限制这一问题,建立可预见性单机干扰管理模型。在这一模型中,工件的加工时间是既与工件所排的加工位置又与工件开始加工的时间有关的函数。同时,在生产过程中由于机器发生故障或定期维修等扰动事件导致机器在某段时间内不能加工工件。目标是在同时考虑原目标函数和由扰动造成的偏离函数的情况下,构建一个新的最优时间表序列。根据干扰度量函数的不同研究了两个问题,第一个问题的目标函数是极小化总完工时间与总误工时间的加权和;第二个问题的目标函数是极小化总完工时间与总提前时间的加权和。对于所研究的问题,首先证明了最优排序具有的性质,然后建立了相应的拟多项式时间动态规划算法。 相似文献
42.
This work proposes an extended version of the well-known tree-augmented naive Bayes (TAN) classifier where the structure learning step is performed without requiring features to be connected to the class. Based on a modification of Edmonds' algorithm, our structure learning procedure explores a superset of the structures that are considered by TAN, yet achieves global optimality of the learning score function in a very efficient way (quadratic in the number of features, the same complexity as learning TANs). We enhance our procedure with a new score function that only takes into account arcs that are relevant to predict the class, as well as an optimization over the equivalent sample size during learning. These ideas may be useful for structure learning of Bayesian networks in general. A range of experiments shows that we obtain models with better prediction accuracy than naive Bayes and TAN, and comparable to the accuracy of the state-of-the-art classifier averaged one-dependence estimator (AODE). We release our implementation of ETAN so that it can be easily installed and run within Weka. 相似文献
43.
Classifying proteins into their respective enzyme class is an interesting question for researchers for a variety of reasons. The open source Protein Data Bank (PDB) contains more than 1,60,000 structures, with more being added everyday. This paper proposes an attention-based bidirectional-LSTM model (ABLE) trained on over sampled data generated by SMOTE to analyse and classify a protein into one of the six enzyme classes or a negative class using only the primary structure of the protein described as a string by the FASTA sequence as an input. We achieve the highest F1-score of 0.834 using our proposed model on a dataset of proteins from the PDB. We baseline our model against eighteen other machine learning and deep learning networks, including CNN, LSTM, Bi-LSTM, GRU, and the state-of-the-art DeepEC model. We conduct experiments with two different oversampling techniques, SMOTE and ADASYN. To corroborate the obtained results, we perform extensive experimentation and statistical testing. 相似文献
44.
Chengzhen Hu Wendong Jia Yao Liu Dr. Yuqin Wang Dr. Panke Zhang Prof. Hong-Yuan Chen Prof. Shuo Huang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(44):e202201033
Acidic catecholamine metabolites, which could serve as diagnostic markers for many diseases, demonstrate an importance of accurate sensing. However, they share a highly similar chemical structure, which is a challenge in the design of sensing strategies. A nanopore may be engineered to sense these metabolites in a single molecule manner. To achieve this, a recently developed programmable nano-reactor for stochastic sensing (PNRSS) technique adapted with a phenylboronic acid (PBA) adaptor was applied. Three acidic catecholamine metabolites, including 3,4-dihydroxyphenylacetic acid (DOPAC), 3,4-dihydroxymandelic acid (DHMA) and 3-methoxy-4-hydroxymandetic acid (VMA) were investigated by PNRSS. Specifically, DHMA, which contains an α-hydroxycarboxylate moiety and an adjacent cis-hydroxyl groups on its benzene ring, reports two binding modes simultaneously resolvable by PNRSS. Assisted with the high resolution of PNRSS, direct regulation of these two binding modes by pH can also be observed. A custom machine learning algorithm was also developed to achieve automatic event classification. 相似文献
45.
ABSTRACTA class of semilinear parabolic reaction diffusion equations with multiple time delays is considered. These time delays and corresponding weights are to be optimized such that the associated solution of the delay equation is the best approximation of a desired state function. The differentiability of the mapping is proved that associates the solution of the delay equation to the vector of weights and delays. Based on an adjoint calculus, first-order necessary optimality conditions are derived. Numerical test examples show the applicability of the concept of optimizing time delays. 相似文献
46.
分析极限理论在数学分析学习中的重要性,介绍学习极限理论的三点经验与体会,即充分理解基本内容;加强基本功训练;试着多问自己一些问题,学会举出各种各样的例子。 相似文献
47.
“奇妙的化学世界”是天津师范大学面向全校非化学专业的本科生开设的一门通识选修课。课程主要采用启发式教学模式、案例式教学模式、互动式教学模式等相结合的混合式教学模式,涉及当今活跃的科研领域和生活实际。课程采用多种方式如图片展示、教学辅助视频、小组讨论、调查问卷等,调动学生的积极性和主动性,使学生在较为轻松的状态下掌握课程内容。此外,力求做到集知识性、实用性、趣味性于一体,避免了化学专业课程中的复杂多变的化学结构描述。 相似文献
48.
Boosting is one of the most important strategies in ensemble learning because of its ability to improve the stability and performance of weak learners. It is nonparametric, multivariate, fast and interpretable but is not robust against outliers. To enhance its prediction accuracy as well as immunize it against outliers, a modified version of a boosting algorithm (AdaBoost R2) was developed and called AdaBoost R3. In the sampling step, extremum samples were added to the boosting set. In the robustness step, a modified Huber loss function was applied to overcome the outlier problem. In the output step, a deterministic threshold was used to guarantee that bad predictions do not participate in the final output. The performance of the modified algorithm was investigated with two anticancer data sets of tyrosine kinase inhibitors, and the mechanism of inhibition was studied using the relative weighted variable importance procedure. Investigating the effect of base learner's strength reveals that boosting is only successful using the classification and regression tree method (a weak to moderate learner) and does not have a significant effect using the radial basis functions partial least square method (a strong base learners). Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
49.
X. Z. Wang F. V. Buontempo A. Young D. Osborn 《SAR and QSAR in environmental research》2013,24(5):451-471
Recent literature has demonstrated the applicability of genetic programming to induction of decision trees for modelling toxicity endpoints. Compared with other decision tree induction techniques that are based upon recursive partitioning employing greedy searches to choose the best splitting attribute and value at each node that will necessarily miss regions of the search space, the genetic programming based approach can overcome the problem. However, the method still requires the discretization of the often continuous-valued toxicity endpoints prior to the tree induction. A novel extension of this method, YAdapt, is introduced in this work which models the original continuous endpoint by adaptively finding suitable ranges to describe the endpoints during the tree induction process, removing the need for discretization prior to tree induction and allowing the ordinal nature of the endpoint to be taken into account in the models built. 相似文献
50.