基于Taylor弥散理论的纳米粒子与蛋白质相互作用研究

在微流控芯片中将Taylor弥散分析(TDA)与激光诱导荧光检测(LIF)结合,测定了荧光素钠标记狗血清蛋白(FITC-DSA)的水合半径为(6.12±1.21)nm,扩散系数为(4.11±0.78)×10-11m2/s;然后,初步研究了FITC-DSA与不同粒径金纳米粒子(AuNPs)的相互作用.研究结果表明,不同粒径的AuNPs与蛋白质的作用不同;50 nm的AuNPs与FITC-DSA作用会导致其荧光信号增强.本研究为高通量测定纳米粒子与蛋白质相互作用提供了一种新方法.本方法具有简单快速、耗样量极少等优点,有助于深入了解纳米材料的毒性,推动安全纳米药物的发展.     

Parameter redundancy in neural networks: an application of Chebyshev polynomials

This paper deals with feedforward neural networks containing a single hidden layer and with sigmoid/logistic activation function. Training such a network is equivalent to implementing nonlinear regression using a flexible functional form, but the functional form in question is not easy to deal with. The Chebyshev polynomials are suggested as a way forward, providing an approximation to the network which is superior to Taylor series expansions. Application of these approximations suggests that the network is liable to a ‘naturally occurring’ parameter redundancy, which has implications for the training process as well as certain statistical implications. On the other hand, parameter redundancy does not appear to damage the fundamental property of universal approximation.      

Modified Householder iterative method for nonlinear equations

In this paper, we suggest and analyze a new two-step predictor–corrector type iterative method for solving nonlinear equations of the type f(x)=0. This new method includes the two-step Newton method as a special case. We show that this new two-step method is a sixth-order convergent method. Several examples are given to illustrate the efficiency of this new method and its comparison with other sixth-order methods. This method can be considered as a significant improvement of the Newton method and its variant forms.     

Reinhardt域B_p上正规化双全纯完全准凸映射的齐次展式

本文主要研究C~n中有界凸Reinhardt域B_p上正规化双全纯完全准凸映射的齐次展开式问题,设f(z):B_p→C~n(p＞2)是一个正规化双全纯完全准凸映射,k是满足k＜p≤k+1的自然数,那么f_j(z)=z_j+α_(j2)z_j~2+…+α_(jk)z_j~k+O(|z|~(K+1)),其中f_j是f的第j个分量,j=1,2…．,n．     

Stability of viscous flow in a rotating porous medium in the form of an annulus: The small-gap problem

The paper deals with the linear stability analysis of laminar flow of a viscous fluid in a rotating porous medium in the form of an annulus bounded by two concentric circular impermeable cylinders. The usual no-slip condition is imposed at both the boundaries. The resulting sixth order boundary value, eigenvalue problem has been solved numerically for the small-gap case by the Runge-Kutta-Gill method, assuming that the marginal state is stationary. The results of computation reveal that the critical Taylor number increases with decreasing permeability of the medium. The problem is found to reduce to the case of ordinary viscous flow in the annulus obtained by Chandrasekhar,¹ when the permeability parameter tends to zero.     

H~（p，α）空间的Hardy－Littlewood定理

本文讨论了与Ｈ￣（ｐ，α）空间有关的乘子问题，得到为Ｈ￣（ｐ，α）到Ｈ￣（ｑ，α）或Ｈ￣（ｐ，α）到ｌ￣ｑ乘子的充分条件．作为应用，证明了一个关于Ｈ￣（ｐ，α）函数的Ｔａｙｌｏｒ系数的猜想．     

Asymptotic expansions for the Laplace approximations for Itô functionals of Brownian rough paths

In this paper, we establish asymptotic expansions for the Laplace approximations for Itô functionals of Brownian rough paths under the condition that the phase function has finitely many non-degenerate minima. Our main tool is the Banach space-valued rough path theory of T. Lyons. We use a large deviation principle and the stochastic Taylor expansion with respect to the topology of the space of geometric rough paths. This is a continuation of a series of papers by Inahama [Y. Inahama, Laplace's method for the laws of heat processes on loop spaces, J. Funct. Anal. 232 (2006) 148-194] and by Inahama and Kawabi [Y. Inahama, H. Kawabi, Large deviations for heat kernel measures on loop spaces via rough paths, J. London Math. Soc. 73 (3) (2006) 797-816], [Y. Inahama, H. Kawabi, On asymptotics of certain Banach space-valued Itô functionals of Brownian rough paths, in: Proceedings of the Abel Symposium 2005, Stochastic Analysis and Applications, A Symposium in Honor of Kiyosi Itô, Springer, Berlin, in press. Available at: http://www.abelprisen.no/no/abelprisen/deltagere_2005.html].     

A two‐phase flow interface capturing finite element method

A new interface capturing algorithm is proposed for the finite element simulation of two‐phase flows. It relies on the solution of an advection equation for the interface between the two phases by a streamline upwind Petrov–Galerkin (SUPG) scheme combined with an adaptive mesh refinement procedure and a filtering technique. This method is illustrated in the case of a Rayleigh–Taylor two‐phase flow problem governed by the Stokes equations. Copyright © 2006 John Wiley & Sons, Ltd.     

A return toward equilibrium in a 2D Rayleigh–Taylor instability for compressible fluids with a multidomain adaptive Chebyshev method

We numerically simulate a single-mode Rayleigh–Taylor instability between compressible miscible fluids with a highly accurate self-adaptive pseudospectral Chebyshev multidomain method in two two-dimensional boxes at small aspect ratios. The simulations are started from rest and pursued until the return toward mechanical equilibrium of the mixing. Four regimes—linear and weakly nonlinear, nonlinear steady bubble rise, return toward equilibrium, and finally a system of acoustic waves—can be identified. We show that this one-dimensional system of stationary acoustic waves is damped by the physical viscosity. This provides a reference solution.      

Pattern Selection: Determined by Symmetry and Modifiable by Distant Effects

We consider Saffman–Taylor channel flow without surface tension on a high-pressure driven interface, but modify the usual infinite-fluid in infinite-channel configuration. Here we include the treatment of efflux by considering a finite connected body of fluid in an arbitrarily long channel, with its second free interface the efflux of this configuration. We show that there is a uniquely determined translating solution for the driven interface, which is exactly the 1/2 width S–T solution, following from correct symmetry for a finite channel flow. We establish that there exist no perturbations about this solution corresponding to a finger propagating with any other width: Selection is locally unique and isolated. The stability of this solution is anomalous, in that all freely impressible perturbations are stabilities, while unstable modes request power proportional to their strength from the external agencies that drive the flow, and so, in principle, are experimentally controllable. This is very different from the behavior of the usual infinite fluid. We conjecture that surface tension on the efflux interface modifies channel-width according to 1–2=/v (i.e., (2)² B of the literature) with v the velocity of the high-pressure tip, but the surface tension of the efflux. That is, is decreased below 1/2 by the effect of smoothing the distant efflux. The perturbation theory created here to deal with transport between two free boundaries is novel and dependent upon a symmetry implied by the equations of motion.