Synthesis,Spectroscopy, Semi‐empirical and Biological Activities of Organotin(IV) Complexes with o‐Isopropyl Carbonodithioic Acid

New organotin(IV) complexes have been synthesized by treating potassium o‐isopropyl carbonodithioate with R₂SnCl₂/R₃SnCl in 1 : 2/1 : 1 M/L ratio. All complexes have been characterized by IR and NMR (¹H, ¹³C) spectroscopy. IR results shows that ligand acts as bidentate which is also confirmed by semi‐empirical study. NMR data reveals four coordinated geometry in solution. Computed positive heat of formation shows that complex 5 is thermodynamically unstable. UV/visible spectroscopy was used to assess the mode of interaction and binding of the complexes with DNA which shows that complex 5 exhibits higher binding constant as compared to complex 3 . In protein kinase inhibition assay, compound 3 was found most active, while other biological activities shows that triorganotin(IV) complexes are biologically more active as compared to diorganotin(IV) complexes.     

非光滑半无限多目标规划弱非控解的充分性

本文利用锥次微分的概念，在一点处定义了η－（Ａ，Ｎ）凸函数、η－（Ａ，Ｎ）伪凸函数和η－（Ａ，Ｎ）严格伪凸函数，在相当弱的假设下，在η－（Ａ，Ｎ）意义下，给出了非光滑η－（Ａ，Ｎ）凸半无限多目标规划弱非控解的一些充分条件。     

A Note on Existence and Convergence of Best Proximity Points for Pointwise Cyclic Contractions

We introduce a notion of pointwise cyclic contraction T satisfying TA ? B and TB ? A to obtain the existence of a point x ∈ A, such that d(x, Tx) = dist(A, B), known as a best proximity point for such a map. We also prove that for any x ∈ A, the Picard iteration {T²ⁿx} converges to a best proximity point.     

Simple,low‐cost fabrication of semi‐circular channel using the surface tension of solder paste and its application to microfluidic valves

This work presents a simple, low‐cost method to fabricate semi‐circular channels using solder paste, which can amalgamate the cooper surface to form a half‐cylinder mold using the surface tension of Sn–Pd alloy (the main component in solder paste). This technique enables semi‐circular channels to be manufactured with different dimensions. These semi‐circular channels will then be integrated with a polymethylmethacrylate frame and machine screws to create miniaturized, portable microfluidic valves for sequential liquid delivery and particle synthesis. This approach avoids complicated fabrication processes and expensive facilities and thus has the potential to be a useful tool for lab‐on‐a‐chip applications.     

Ultrafiltration‐LC–MS combined with semi‐preparative HPLC for the simultaneous screening and isolation of lactate dehydrogenase inhibitors from Belamcanda chinensis

Stroke represents the fourth leading cause of death in the USA and the second leading cause of death worldwide. Lactate dehydrogenase inhibitors are widely used in the treatment of ischemic stroke and natural products are considered a promising source of novel lactate dehydrogenase inhibitors. In this study, we used PC12 cells to determine the protective effect of extracts from the herb Belamcanda chinensis following toxic challenge. Using ultrafiltration high‐performance liquid chromatography coupled with photo‐diode array detection and electrospray ionization mass spectrometry, we screened and identified isoflavonoids from Belamcanda chinensis extracts. Semi‐preparative high‐performance liquid chromatography was then applied to separate and isolate the active constituents. Using these methods, we identified six major compounds in Belamcanda chinensis as lactate dehydrogenase inhibitors: tectoridin, iristectorin A, iridin, tectorigenin, irigenin, and irisflorentin, which were then isolated to >92% purity. This is the first report that Belamcanda chinensis extracts contain potent lactate dehydrogenase inhibitors. Our results demonstrate that the systematic isolation of bioactive components from Belamcanda chinensis guided by ultrafiltration high‐performance liquid chromatography coupled with photo‐diode array detection and electrospray ionization mass spectrometry represents a feasible and efficient technique that could be extended for the identification and isolation of other enzyme inhibitors.     

Controllability of Linear Systems in Non Reflexive Banch Spaces

§ 1.Introduction　 Let Xand Ube Banch spaces,S(t) a C0 semi-group in X,A the infinitesimal gen-erator of S(t) ,and B∈L(U,X) .Consider the systemΣP:x(t) =Ax(t) + Bu(t) ,　 t≥ 0 ,(1 .1 )where u∈ Lploc([0 ,∞ ) ,U) ,1≤p<∞ .　 The problem of controllability of linear systems in Banch spaces has been studied bymany authors.In [1 ] ,the weak and strong reachability and controllability of infinite di-mensional linear systems were investigated.In[2 ,3 ,4 ] ,the controllability of infi…     

Fluorescence characteristics of Dy/CdS nanocrystals doped silica xerogel

Cadmium sulfide semiconductor nanocrystals along with dysprosium ions were incorporated in silica xerogels through sol-gel route. The fluorescence properties were analyzed for samples annealed at different temperatures. The incorporation of the CdS semiconductors as nanocrystallites was confirmed from the HRTEM measurements. The fluorescence intensities were compared for Dy³⁺, CdS and Dy³⁺/CdS-doped silica xerogels. Enhanced blue emission was observed for codoped samples annealed up to 100 °C.     

苯乙双胍在人体内形成一氧化氮的机理研究

探讨了一氧化氮(NO)在一氧化氮合酶(NOS)的作用下通过氧化苯乙双胍的末端氮原子N1而合成的机理.在这个过程中,化合物的氧化是通过过氧甲酸HCOOOH(Performic acid)来实现的.我们以AM1计算为基础,在NO形成的反应路径上,研究了化合物的中间产物(speciesB、C、D、E),并得到了这些分子的最优化结构.此机制所释放的产物为HNO,它很容易产生NO.通过研究C3-O15和C3-N1原子间距离的变化,我们讨论了这个机制的合理性.     

一种新型的三维半解析数值算法

在三维空间,结合有限元线法与有限层法的思想,构造了一种新型的半解析数值算法,数值结果表明该方法具有较高的精度,切实可行。     

图的光滑支架分解

设G是一个图,A为其边集的子集。G的一个支架分解是（G－A,A）,其中G－A是去掉A后的连通图,G的一个光滑支架分解是适合下列条件的支架分解：（1）G－A的每一叶具有连通余树;（2）G－B（G－A）割边集为A,其中B（G－A）为G－A的割边集。本文给出了求一个图的光辉支架分解的一个有效算法。