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101.
A. V. Mastikhin 《Mathematical Notes》2007,82(5-6):787-797
We consider the Kolmogorov equations for the transition probabilities of a three-dimensional Markov process of special form. For a stationary first equation, an exact solution is obtained using the Riemann method. We obtain asymptotics for the expectation and variance of the final distribution and establish a limit theorem. 相似文献
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Zhimin Han;Yi Wang ;Zhen Jin 《Discrete and continuous dynamical systems》2024,29(11):4432-4462
Multi-scale coupled models provide a new idea to understand how within-host dynamics impact disease spread between hosts. In previous studies, many theoretical results have been obtained on multi-scale coupled models, but little attention has been paid to the issue of final and peak epidemic sizes. In this work, we first develop a multi-scale homogeneous susceptible-infected-recovered (SIR) model by linking the within- and between-host models using link functions. The existence and uniqueness of the solution of the model are established, the epidemiological reproduction number and final and peak epidemic sizes equations are derived, and the uniqueness of the solution of the final size equation is proved. Specifically, we draw on the concept of separating biological time scales to derive the peak arrival time and the duration of the epidemic. Then, we further explore the effect of contact heterogeneity between individuals on the epidemiological quantities obtained above. We consider the multi-scale heterogeneous network SIR model, give the epidemiological reproduction number and the final epidemic size equation, and prove the uniqueness of the solution to the final size equation. Moreover, the sensitivity of the epidemiological reproduction number of the multi-scale homogeneous SIR model to each parameter of the within-host model and the influence of the degree distribution on the dynamic behavior of the multi-scale heterogeneous network SIR model are analyzed. These results are useful not only for understanding how multi-scale model assumptions may affect the critical quantities but also for confirming which factors are more important in determining the epidemic. 相似文献
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105.
An epidemic models of SIR type and SIRS type with general contact rate and constant immigration of each class were discussed by means of theory of limit system and suitable Liapunov functions. In the absence of input of infectious individuals, the threshold of existence of endemic equilibrium is found. For the disease-free equilibrium and the endemic equilibrium of corresponding SIR model, the sufficient and necessary conditions of global asymptotical stabilities are all obtained. For corresponding SIRS model, the sufficient conditions of global asymptotical stabilities of the disease-free equilibrium and the endemic equilibrium are obtained. In the existence of input of infectious individuals, the models have no disease-free equilibrium. For corresponding SIR model, the endemic equilibrium is globally asymptotically stable ; for corresponding SIRS model, the sufficient conditions of global asymptotical stability of the endemic equilibrium are obtained. 相似文献
106.
借助极限系统理论和构造适当的Liapunov函数,对带有一般接触率和常数输入的SIR型和SIRS型传染病模型进行讨论.当无染病者输入时,地方病平衡点存在的阈值被找到A·D2对相应的SIR模型,关于无病平衡点和地方病平衡点的全局渐近稳定性均得到充要条件;对相应的SIRS模型,得到无病平衡点和地方病平衡点全局渐近稳定的充分条件.当有染病者输入时,模型不存在无病平衡点.对相应的SIR模型,地方病平衡点是全局渐近稳定的;对相应的SIRS模型,得到地方病平衡点全局渐近稳定的充分条件. 相似文献
107.
从三种冠状病毒主要蛋白酶SARS 3CL, HCoV 3CL和TGEC 3CL蛋白酶结构出发,着重研究了三种蛋白酶二聚体单体之间的静电和疏水相互作用.用连续介质模型有限差分方法计算得到三种蛋白二聚体界面处的静电势,发现三种蛋白酶单体和单体之间静电势分布具有明显的互补性,三种蛋白酶二聚体单体之间具有相同的静电相互作用能.用溶剂可及表面积模型分析了分子表面积及疏水性,发现三种蛋白酶具有相同的疏水分布,其中SARS 3CL蛋白酶疏水率为74%,驱动其单体聚合成二聚体.对三种蛋白酶的去溶剂化能疏水项的计算表明,三种蛋白酶二聚体单体之间具有相似的疏水相互作用能. 相似文献
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109.
As the break out of COVID-19 epidemic, the prevention and control work was consequently carried out. Chemistry plays an important role in the white war. The structure of mask contains the knowledge of interfacial chemistry. The material of mask encompasses the knowledge of polymer chemistry. Nucleic acid test and COVID-19 vaccine research need the knowledge of biological chemistry. The sanitizers involve the knowledge of inorganic and organic chemistry. The knowledge of physical chemistry takes effect in daily hand washing with soap. Each drug against COVID-19 virus was a complex organic compound. All the above things can be taken as appropriate examples in chemistry teaching to display the charm of chemistry. Meanwhile, these examples help students to realize that chemistry works as a vital part in our lives and therefore active their motivation to study chemistry well. 相似文献
110.