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81.
Xiang Li Xiaojin Zhang Haopeng Sun Lei Zhang Yuan Gao Jinxin Wang Qinglong Guo Qidong You 《中国化学》2012,30(5):1083-1091
Gambogic acid (GA, 1 ), the most prominent representative of Garcinia natural products, has been reported to be a promising anti‐tumor agent. In order to further explore the structure‐activity relationship of GA and discover novel GA derivatives as anti‐tumor agents, 17 novel C‐37 modified derivatives of GA were synthesized and evaluated for their in vitro anti‐tumor activities against A549, HCT‐116, BGC‐823, HepG2 and MCF‐7 cancer cell lines. Among them, 11 compounds were found to be more potent than GA against some cancer cell lines. Notably, compound 8 was almost 5–10 folds more active than GA against A549 and BGC‐823 cell lines with the IC50 values of 0.12 µmol·L?1 and 0.57 µmol·L?1, respectively. Chemical modification at C‐37 position of GA by introducing of hydrophilic amines could lead to increased activity and improved drug‐like properties. These findings will enhance our understanding of the structure‐activity relationship (SAR) of GA and lead to the discovery of novel GA derivatives as potential anti‐tumor agents. 相似文献
82.
Yuan‐Yuan Liu Hong Shi Guang‐Ke He Guang‐Liang Song Hong‐Jun Zhu 《Helvetica chimica acta》2012,95(9):1645-1656
Five novel pyrazole‐coupled glucosides, 1,5‐diaryl‐1H‐pyrazol‐3‐yl 2,3,4,6‐tetra‐O‐acetyl‐β‐D ‐glucopyranosides 5a – 5e , were synthesized by the phase‐transfer catalytic reaction of 1,5‐diaryl‐1H‐pyrazol‐3‐ols 4a – 4e with acetobromo‐α‐D ‐glucose in H2O/CHCl3 under alkaline conditions, using Bu4N+Br? as catalyst. Then, glucosides 5a – 5c were deacetylated in a solution of Na2CO3/MeOH to yield the 1,5‐diaryl‐3‐(β‐D ‐glucopyranosyloxy)‐1H‐pyrazoles 6a – 6c . Their structures were characterized by 1H,1H‐COSY, 1H‐, 13C‐, and 19F‐NMR spectroscopy, as well as elemental analysis. The structures of 5d and 6c were also determined by single‐crystal X‐ray diffraction analysis. A preliminary in vitro bioassay indicated that compounds 4e and 5d exhibited excellent‐to‐medium fungicidal activity against Sclerotinia sclerotiorum at the dosage of 10 μg/ml. 相似文献
83.
Christina L. Sammet Xiangyu Yang Peter A. Wassenaar Eric C. Bourekas Brian A. Yuh Frank Shellock Steffen Sammet Michael V. Knopp 《Magnetic resonance imaging》2013
Purpose
The purpose was to evaluate radiofrequency (RF)-related heating of commonly used extracranial neurosurgical implants in 7-T magnetic resonance imaging (MRI).Materials and methods
Experiments were performed using a 7-T MR system equipped with a transmit/receive RF head coil. Four commonly used titanium neurosurgical implants were studied using a test procedure adapted from the American Society for Testing and Materials Standard F2182-11a. Implants (n = 4) were tested with an MRI turbo spin echo pulse sequence designed to achieve maximum RF exposure [specific absorption rate (SAR) level = 9.9 W/kg], which was further validated by performing calorimetry. Maximum temperature increases near each implant's surface were measured using fiberoptic temperature probes in a gelled-saline-filled phantom that mimicked the conductive properties of soft tissue. Measurement results were compared to literature data for patient safety.Results
The highest achievable phantom averaged SAR was determined by calorimetry to be 2.0 ± 0.1 W/kg due to the highly conservative SAR estimation model used by this 7-T MR system. The maximum temperature increase at this SAR level was below 1.0 °C for all extracranial neurosurgical implants that underwent testing.Conclusion
The findings indicated that RF-related heating under the conditions used in this investigation is not a significant safety concern for patients with the particular extracranial neurosurgical implants evaluated in this study. 相似文献84.
Research on synthetic aperture radar imaging technology of one-dimensional layered rough surfaces 下载免费PDF全文
A quick and exact imaging method for one-dimensional layered rough surfaces is proposed in this paper to study the scattering characteristics of a layered medium that exists widely in nature.The boundary integral equations of layered rough surfaces are solved by using the propagation-inside-layer expansion combined with the forward and backward spectral acceleration method(PILE+FB-SA),and the back scattering data are obtained.Then,a conventional synthetic aperture radar(SAR) imaging procedure called back projection method is used to generate a two-dimensional(2D) image of the layered rough surfaces.Combined with the relative dielectric permittivity of realistic soil,the random rough surfaces with Gauss spectrum are used to simulate the layered medium with rough interfaces.Since the back scattering data are computed by using the fast numerical method,this method can be used to study layered rough surfaces with any parameter,which has a great application value in the detection and remote sensing areas. 相似文献
85.
Because of advances in the high-throughput screening technology, identification of a hit that can bind to a target protein
has become a relatively easy task; however, in the process of drug discovery, the following hit-to-lead and lead optimization
still remain challenging. In a typical hit-to-lead and lead optimization process, the analogues of the most promising hits
are synthesized for the development of structure–activity relationship (SAR) analysis, and in turn, in the effort of optimization
of lead compounds, such analysis provides guidance for the further synthesis. The synthesis processes are usually long and
labor-intensive. In silico searching has becoming an alternative approach to explore SAR especially with millions of compounds
ready to be screened and most of them can be easily obtained. Here, we report our discovery of 15 new Dishevelled PDZ domain
inhibitors by using such an approach. In our studies, we first developed a pharmacophore model based on NSC668036, an inhibitor
previously identified in our laboratory; based on the model, we then screened the ChemDiv database by using an algorithm that
combines similarity search and docking procedures; finally, we selected potent inhibitors based on docking analysis and examined
them by using NMR spectroscopy. NMR experiments showed that all the 15 compounds we chose bound to the PDZ domain tighter
than NSC668036. 相似文献
86.
87.
N. Jon Shah Joachim B. Kaffanke Sandro Romanzetti 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2009,199(2):136-145
Single point imaging methods such as SPRITE are often the technique of choice for imaging fast-relaxing nuclei in solids. Single point imaging sequences based on SPRITE in their conventional form are ill-suited for in vivo applications since the acquisition time is long and the SAR is high. A new sequence design is presented employing variable repetition times and variable flip angles in order to improve the characteristics of SPRITE for in vivo applications. The achievable acquisition time savings as well as SAR reductions and/or SNR increases afforded by this approach were investigated using a resolution phantom as well as PSF simulations. Imaging results in phantoms indicate that acquisition times may be reduced by up to 70% and the SAR may be reduced by 40% without an appreciable loss of image quality. 相似文献
88.
Marc Montana Vincent Montero Omar Khoumeri Patrice Vanelle 《Molecules (Basel, Switzerland)》2021,26(16)
Background. The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to develop new agents with faster and more efficient action. The versatile quinoxaline ring possesses a broad spectrum of pharmacological activities, ensuring considerable attention to it in the field of medicinal chemistry. Objectives. In continuation of our program on the pharmacological activity of quinoxaline derivatives, this review focuses on potential antimycobacterial activity of recent quinoxaline derivatives and discusses their structure—activity relationship for designing new analogs with improved activity. Methods. The review compiles recent studies published between January 2011 and April 2021. Results. The final total of 23 studies were examined. Conclusions. Data from studies of quinoxaline and quinoxaline 1,4-di-N-oxide derivatives highlight that specific derivatives show encouraging perspectives in the treatment of Mycobacterium tuberculosis and the recent growing interest for these scaffolds. These interesting results warrant further investigation, which may allow identification of novel antitubercular candidates based on this scaffold. 相似文献
89.
Parallel excitation using multiple transmit channels has emerged as an effective method to shorten multidimensional spatially selective radiofrequency (RF) pulses, which have a number of important applications, including B1 field inhomogeneity correction in high-field MRI. The specific absorption rate (SAR) is a primary concern in high-field MRI, where wavelength effects can lead to local peaks in SAR. In parallel excitation, the subjects are exposed to RF pulses from multiple coils, which makes the SAR problem more complex to analyze, yet potentially enables greater freedom in designing RF pulses with lower SAR. Parallel-excitation techniques typically employ either Cartesian or constant-density (CD) spiral trajectories. In this article, variable-density (VD) spiral trajectories are explored as a means for SAR reduction in parallel-excitation pulse design. Numerical simulations were conducted to study the effects of CD and VD spirals on parallel excitation. Specifically, the electromagnetic fields of a four-channel transmit head coil with a three-dimensional head model at 4.7 T were simulated using a finite-difference time domain method. The parallel RF pulses were designed and the resulting excitation patterns were generated using a Bloch simulator. The SAR distributions due to CD and VD spirals were evaluated quantitatively. The simulation results show that, for the same pulse duration, parallel excitation with VD spirals can achieve a lower SAR compared to CD spirals for parallel excitation. VD spirals also resulted in reduced artifact power in the excitation patterns. This gain came with slight, but noticeable, degrading of the spatial resolution of the resulting excitation patterns. 相似文献
90.
M. S. Johansen P. Alstrom J. Borg M. T. Levinsen 《The European Physical Journal B - Condensed Matter and Complex Systems》1999,11(4):665-676
Significant statistical bias in LDA measurements and how to adequately deal with it is a subtle problem when dealing with
turbulent flows. In order to attempt a clarification we have performed measurements on a non-standard “grid experiment” where
a clear bias effect is found. We have investigated the effect of several corrective measures and find that best results, in
the sense of having the first moment converge to zero, are obtained when using the time between events as statistical weights.
The corrected time series have been used to check for extended self-similarity (ESS). Even though no scaling regime is seen
for the third moment and the flow certainly is neither isotropic nor homogeneous, perfect ESS scaling based on the absolute
third moment is observed up to the twelfth moment, extending into a time domain regime where the Taylor hypothesis of frozen
turbulence is obviously violated. Reversing the argument this indicates that the correction scheme needed can be experimentally
decided on using the criterion stated above and especially so if ESS is to be expected. Finally we have used the corrected
data to quantify the deviations from Gaussian behavior of the velocity difference probability density function for a weakly
turbulent flow. Through comparison with results on the Gaussian-Lorentzian distribution we find that the even part of the
experimental distribution can be reproduced quite well by a single-parameter family of distributions with second moment equal
unity.
Received 5 August 1998 and Received in final form 21 December 1998 相似文献