首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   193篇
  免费   11篇
  国内免费   19篇
化学   148篇
力学   9篇
综合类   3篇
数学   2篇
物理学   61篇
  2023年   3篇
  2022年   13篇
  2021年   19篇
  2020年   8篇
  2019年   3篇
  2018年   4篇
  2017年   8篇
  2016年   7篇
  2015年   7篇
  2014年   14篇
  2013年   36篇
  2012年   14篇
  2011年   10篇
  2010年   3篇
  2009年   12篇
  2008年   5篇
  2007年   8篇
  2006年   13篇
  2005年   6篇
  2004年   3篇
  2003年   2篇
  2002年   6篇
  2001年   2篇
  2000年   1篇
  1999年   4篇
  1997年   1篇
  1996年   2篇
  1995年   2篇
  1994年   3篇
  1992年   1篇
  1988年   1篇
  1987年   1篇
  1982年   1篇
排序方式: 共有223条查询结果,搜索用时 15 毫秒
161.
QuantitativeStudiesonStructure-ActivityRelationships(QSAR)ofCytokinin-ActivePhenylUreaDerivatives(PUn)QIAOLi-xin;LIZheng-ming...  相似文献   
162.
A series of novel 5-[(Z,2Z)-2-chloro-3-(4-nitrophenyl)-2-propenylidene]-thiazolidinones (Ciminalum–thiazolidinone hybrid molecules) have been synthesized. Anticancer activity screening toward the NCI60 cell lines panel, gastric cancer (AGS), human colon cancer (DLD-1), and breast cancer (MCF-7 and MDA-MB-231) cell lines allowed the identification of 3-{5-[(Z,2Z)-2-chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}propanoic acid (2h) with the highest level of antimitotic activity with mean GI50/TGI values of 1.57/13.3 μM and a certain sensitivity profile against leukemia (MOLT-4, SR), colon cancer (SW-620), CNS cancer (SF-539), melanoma (SK-MEL-5), gastric cancer (AGS), human colon cancer (DLD-1), and breast cancers (MCF-7 and MDA-MB-231) cell lines. The hit compounds 2f, 2i, 2j, and 2h have been found to have low toxicity toward normal human blood lymphocytes and a fairly wide therapeutic range. The significant role of the 2-chloro-3-(4-nitrophenyl)prop-2-enylidene (Ciminalum) substituent in the 5 position and the substituent’s nature in the position 3 of core heterocycle in the anticancer cytotoxicity levels of 4-thiazolidinone derivatives have been established  相似文献   
163.
164.
Despite all the progress made to enrich the existing bank of drugs used to treat and cure Alzheimer and cancer patients, there is still a need to research and develop new bioactive candidates with superior efficacy but minimal side effects. In this context, a new series of anti-butyrylcholinesterase (anti-BChE), anti-tyrosinase and cytotoxic succinimide linked quinaldine conjugates 3a-i was designed and synthesized starting from 8-hydroxyquinaldine. The condensation of quinoleine-hydrazide 2 with electrophilic species such as aromatic and nonaromatic anhydrides provided the new compounds 3a-i. These synthesized heterocycles were characterized by spectroscopic means (1H NMR, 13C NMR and ESI-HRMS). Their anti-butyrylcholinesterase, anti-tyrosinase and cytotoxic (cervical cancer cell (HeLa) and lung cancer cell (A549)) activities have been evaluated in vitro. Compounds 3e and 3 g were found to be more anti-BChE than Galanthamine. Compounds 3d, 3e and 3 g exerted better anti-tyrosinase activity than kojic acid. Also, 3a, 3f and 3 g showed interesting cytotoxic potential towards HeLa cell lines. These results were supported by the molecular docking analysis (structure–activity relationship (SAR)) to estimate and discuss possible interactions between these derivatives and active sites of proteins butyrylcholinesterase (PDB: 4B0P), tyrosinase (PDB: 2Y9X) and cytotoxic (topoisomerase IIα enzyme (PDB: 5GWK)).  相似文献   
165.
Structure-activity relationship (SAR) and/or quantitative structure-activity relationship (QSAR) studies play an important role in a lead optimization of drug discovery research. When there is a lack of ligand-bound protein structural information, one of the assumptions in SAR and QSAR studies is that similar analogs bind to the same binding site in a similar binding mode. In such studies, outliers have often been observed, especially in QSAR. However, most of these studies have focused their attention on the development of QSAR and left outliers unattended. We searched ligand-bound X-ray crystal structures from the protein structure database to find evidences that could indicate a possible source of outliers in SAR or QSAR. Our results showed the possibility of conformational changes in a flexible binding site as one possible source of outliers. Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.  相似文献   
166.
一本文介绍了机载合成孔径雷达天线稳定平台的设计方案、理论分析及实验结果,包括平台框架、稳定回路、跟踪回路及误差补偿。  相似文献   
167.
姬伟杰  童创明 《计算物理》2012,29(5):745-752
提出一种快速实现一维粗糙地表面下方埋藏金属目标的成像算法.用层内波传播算法结合谱加速的前后向迭代算法(PILE+FB-SA)计算一维粗糙面下方埋藏金属目标的后向散射;用得到的后向散射数据结合后向投影算法实现二维SAR(synthetic aperture radar)成像,研究窗函数的选取,讨论目标位置及尺寸大小变化的影响.用具有高斯谱的粗糙面模拟实际地表面,并采用锥形波入射以减小人为截断粗糙面引起的边缘效应.由于散射数据由快速数值算法得到,该算法不受地面和目标参数限制,可以实现任意粗糙地表面和复杂目标成像,对地下目标探测具有重要的应用价值.  相似文献   
168.
针对粒子滤波存在的粒子退化和重要性密度函数难以选取的问题,在吸收抗差自适应滤波、二阶插值滤波和粒子滤波算法优点的基础上,提出了一种新的抗差自适应插值粒子滤波算法。该算法利用二阶插值滤波算法得到重要性密度函数,通过抗差自适应因子实时控制动力学模型误差及观测异常对导航解的影响。将该算法应用于SINS/CNS/SAR组合导航系统进行计算仿真,并与经典的粒子滤波算法进行比较分析。结果表明,提出的滤波算法得到的姿态误差控制在[-0.3′,+0.3′],速度误差控制在[-0.4 m/s,+0.4 m/s],位置误差控制在[-5 m,+5 m],性能明显优于经典的粒子滤波算法。新的滤波算法不但能够有效地抑制粒子退化,而且能够有效地控制动力学模型误差及观测异常的影响,提高了组合导航的滤波精度。  相似文献   
169.
李征  李援朝 《化学进展》2009,21(12):2483-2491
雷公藤是我国拥有的一种资源比较丰富的传统中草药。其中的主要活性成分雷公藤内酯醇是一种具有3个环氧基团以及一个α, β-不饱和五元内酯环结构的构型独特的松香烷型二萜化合物,具有明显的抗炎、免疫抑制、抗肿瘤及抗雄性生育等生物活性,自被发现以来,吸引了众多药物化学家及药理学家的广泛关注。通过对雷公藤内酯醇结构多样性改造和修饰,包括对C14-位羟基、C12, C13-位环氧、α, β-不饱和五元内酯环、C7,C8-位环氧、C5,C6-位的修饰,以及三环氧开环的改造,合成出了一系列雷公藤内酯醇衍生物,并进行了相关的药理活性测试。总结雷公藤环氧二萜类结构类似物的药理测试结果,初步得出了一些构效关系的特点。随着针对雷公藤内酯醇各个位点进行结构多样性改造所获得的衍生物以及相应的系统性药理活性测试的不断积累与深化,雷公藤内酯醇的结构与活性关系(SAR)也必定越来越明朗。合成低毒性、高活性、宽治疗视窗的雷公藤内酯醇衍生物是该领域众多药物化学家和药理学家的共同目标,从而使雷公藤在更多的领域中具有更广阔的应用前景。  相似文献   
170.
Diabetes mellitus is a major health problem globally. The management of carbohydrate digestion provides an alternative treatment. Flavonoids constitute the largest group of polyphenolic compounds, produced by plants widely consumed as food and/or used for therapeutic purposes. As such, isoxazoles have attracted the attention of medicinal chemists by dint of their considerable bioactivity. Thus, the main goal of this work was to discover new hybrid molecules with properties of both flavonoids and isoxazoles in order to control carbohydrate digestion. Moreover, the trifluoromethyl group is a key entity in drug development, due to its strong lipophilicity and metabolic stability. Therefore, the present work describes the condensation of a previously synthesized trifluoromethylated flavonol with different aryl nitrile oxides, affording 13 hybrid molecules indicated as trifluoromethylated flavonoid-based isoxazoles. The structures of the obtained compounds were deduced from by 1H NMR, 13C NMR, and HRMS analysis. The 15 newly synthesized compounds inhibited the activity of α-amylase with an efficacy ranging from 64.5 ± 0.7% to 94.7 ± 1.2% at a concentration of 50 μM, and with IC50 values of 12.6 ± 0.2 μM–27.6 ± 1.1 μM. The most effective compounds in terms of efficacy and potency were 3b, 3h, 3j, and 3m. Among the new trifluoromethylated flavonoid-based isoxazoles, the compound 3b was the most effective inhibitor of α-amylase activity (PI = 94.7 ± 1.2% at 50 μM), with a potency (IC50 = 12.6 ± 0.2 μM) similar to that of the positive control acarbose (IC50 = 12.4 ± 0.1 μM). The study of the structure–activity relationship based on the molecular docking analysis showed a low binding energy, a correct mode of interaction in the active pocket of the target enzyme, and an ability to interact with the key residues of glycosidic cleavage (GLU-230 and ASP-206), explaining the inhibitory effects of α-amylase established by several derivatives.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号