二次旋转设计和反向人工神经网络在铅、镉、汞、镍同时测定中的应用

利用二次通用旋转组合设计法建立了吸光度与显色剂，增敏剂用量及pH 值之间的数学模型，进而得出使吸光度最大的显色剂用量，增敏剂用量及PH值，在优化的基础上，用B－P人工地Pb,Cd,Hg,Ni同时测定的数据进行解析，并与经典最小二乘法进行了对比，结果较准确。     

旋转流体实验设备改造

论述了旋转流体实验装置改造所存在的问题及改进的措施。     

Experimental Overview of Mass Measurements

Nuclear masses and binding energies are an important input for nuclear models, constituting strong constraints far from the β-stability valley. During the last decade, new experimental techniques for the production of exotic nuclei and the measurement of their mass were developed. The present paper gives an overview of these techniques. This revised version was published online in July 2006 with corrections to the Cover Date.     

利用VB实现焊接方法的优化设计

对于某种母材和接头形式，当有多种焊接方法可实现焊接时，依据优化设计的思想．建立评价函数．用计算机对焊接方法进行优化设计．本文采用VB编制程序．当用户输入焊缝基本情况和对焊接质量、焊接效率及生产成本的要求时．即可得到最优、次优的几种焊接方法以供用户选择．并可选择打印某方法的焊接工艺卡片．     

基于有机化学专业课程培养本科生成就动机的形成——以“对映异构”教学设计为例

Taking the enantiotopic chapter of organic chemistry as an example, this paper explores the teaching reform to form the ability and habit of lifelong learning by improving students' dominant position in learning and to guide undergraduates to cultivate the right achievement motivation. It also tries to provide useful references for the teaching of specialized courses in colleges and universities.     

Synthesis and self‐assembly of poly(styrene)‐b‐poly(N‐vinylpyrrolidone) amphiphilic diblock copolymers made via a combined ATRP and MADIX approach

Amphiphilic diblock copolymers of polystyrene (PS) and poly(N‐vinylpyrrolidone) (PNVP) were prepared by a combination of ATRP and MADIX. Well‐defined PS with bromine end group was synthesized by ATRP in bulk at 110 °C using (1‐bromoethyl) benzene as an initiator. The Br‐ end group was then converted to xanthate as verified by ¹H NMR spectroscopy, elemental analysis, and UV‐spectroscopy. PS‐b‐PNVP copolymers were produced by MADIX of NVP in bulk at 60 °C using PS‐xanthate as a macro‐chain transfer agent and the kinetics of polymerization were investigated. The structures of PS‐b‐PNVP were characterized using GPC and ¹H NMR. Amphiphilic PS‐b‐PNVP could form spherical micelles with PS cores and PNVP shells in aqueous solution as confirmed by ¹H NMR and laser light scattering (LLS). The values of critical micelle concentration of PS‐b‐PNVP and the average aggregation number of PS‐b‐PNVP in the micelles were measured using pyrene as a probe and static LLS, respectively. The aggregation number increases concomitantly with temperature (10–50 °C), but the hydrodynamic radius of the micelles remains almost constant over the same temperature range, which may indicate shell dehydration at a higher temperature. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 5604–5615, 2008     

二维井眼轨道设计模型及应用

讨论了一般二维井眼轨道设计问题.建立了二维轨道设计一般数学模型,根据轨道设计约束方程,可任意选择两个设计参数作为未知数进行求解,得到了全部解析计算公式.这种方法设计计算简单、精确、快速、灵活,具有普遍适用性.可广泛用于二维定向井、水平井和多目标井的设计,为井眼轨道设计提供了理论依据.     

Q和Q_B准则在Double设计中的应用

一阶回归模型通常用来从众多因子当中筛选出效应显著的因子,而Q和QB准则能够比较简单地从众多合格的拟合子模型中找出最优设计.因此本文主要探讨了极大模型为一阶回归模型时,初始设计d分别与Double设计d dd-d,完全反转设计d-d,设计dd11-dd22之间的关系,以及它们在Q和QB准则下的最优性关系.     

‘Morphs’ (MRFs): metal-reversible folding domains for differential IgG binding

BACKGROUND: Selective recognition and binding of IgG molecules is the basis for a host of immunological and affinity purification techniques. Capture of an IgG in these procedures relies chiefly on its interaction with one of a variety of reengineered bacterial receptors which bind to the Fc region of IgG molecules with very high affinity. While this interaction is extremely efficient in trapping IgG molecules, the tight interaction between the binding partners often requires denaturing conditions for disruption of the complex, which can adversely affect the yield of purified IgG and also limit the lifetime of the receptor matrix. An effective receptor/IgG binding system which could be modulated by less extreme conditions is of considerable general interest. RESULTS: We describe the properties of a series of modified Fc receptor domains which are competent to bind IgG with high affinity but which can be reversibly unfolded upon addition of modest amounts of transition metal ions. Data are presented demonstrating loss of the secondary structural content of the domains as a function of increasing metal concentration, with a concomitant decrease in IgG binding affinity. Variants of the Fc receptor differing at a single amino acid position display increased sensitivity to metal-induced unfolding, while retaining comparable IgG binding ability in the absence of metal. CONCLUSIONS: The interaction of this series of Fc receptors with metal ions abolishes IgG binding, but removal of metal ions allows refolding of the domains with restoration of the IgG binding function. Examples of the utility and potential applications of these metal-modulated IgG binding domains are discussed.