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151.
Jančić-Stojanović B Rakić T Kostić N Vemić A Malenović A Ivanović D Medenica M 《Talanta》2011,85(3):1453-1460
In this paper a new chromatographic response function (CRF) is designed and proposed for utilization in the optimization strategies. The function capability to represent the overall quality of a experimentally obtained chromatograms was compared to the other two objective functions and proved to give more accurate and reliable results. The new CRF has improved concept of separation and time term estimation. It reflects all important defects of the chromatogram such as the appearance of asymmetrical or overlapping peaks and prolonged elution time and allows the appropriate weighting of each of them. The LC separation of raloxifene and its four impurities was evaluated through the central composite design experimental plan choosing the new CRF to be the only output of the system. The function demonstrated the ability to judge the impact of the complex interactions of the selected chromatographic parameters (acetonitrile content in the mobile phase, sodium dodecyl sulfate concentration in the water phase, pH of the mobile phase and column temperature) on the mixture behavior and led to the determination of the optimal separation conditions. The newly developed CRF proved to have the advanced performances and it presents the important step forward in the optimization of the chromatographic separation. 相似文献
152.
153.
We modeled and studied the separation of uracil, nicotinamide, resorcinol, theobromine, theophylline, and caffeine on four C-18 columns of different lengths packed with the same stationary phase using water/methanol mobile phase at one temperature. Predictions of retention times and peak widths were compared with experimental results and were found to be sufficiently accurate for performing optimization calculations. With limits set on the required resolution and on maximum values for pressure and flow rate, calculations were performed for numerous virtual column lengths seeking the smallest possible analysis time for each length while allowing methanol concentration and flow rate to vary as required to minimize run time. Predictions were experimentally verified for the column lengths actually available. These calculations revealed the dependence of best-possible analysis time on column length, modifier concentration, flow rate, and pressure for the real system that was modeled, and provided insight into parameter interactions with respect to analysis times meeting the needs and limits specified. We show that when these parameters are considered in concert, rather than individually, conventional guidelines regarding setting their values may not always lead to the optimum. 相似文献
154.
Dabre R Azad N Schwämmle A Lämmerhofer M Lindner W 《Journal of separation science》2011,34(7):761-772
Several methods for the separation of vitamins on HPLC columns were already validated in the last 20 years. However, most of the techniques focus on separating either fat- or water-soluble vitamins and only few methods are intended to separate lipophilic and hydrophilic vitamins simultaneously. A mixed-mode reversed-phase weak anion exchange (RP-WAX) stationary phase was developed in our laboratory in order to address such mixture of analytes with different chemical characteristics, which are difficult to separate on standard columns. The high versatility in usage of the RP-WAX chromatographic material allowed a baseline separation of ten vitamins within a single run, seven water-soluble and three fat-soluble, using three different chromatographic modes: some positively charged vitamins are eluted in ion exclusion and ion repulsion modes whereas the negatively charged molecules are eluted in the ion exchange mechanism. The non-charged molecules are eluted in a classical reversed-phase mode, regarding their polarities. The method was validated for the vitamin analysis in tablets, evaluating selectivity, robustness, linearity, accuracy, and precision. The validated method was finally employed for the analysis of the vitamin content of some commercially available supplement tablets. 相似文献
155.
Ruiyue Lin 《Applied mathematics and computation》2011,218(7):3680-3688
An issue of considerable importance involves the allocation of fixed costs or common revenue among a set of competing entities in an equitable way. Based on the data envelopment analysis (DEA) theory, this paper proposes new methods for (i) allocating fixed costs to decision making units (DMUs) and (ii) distributing common revenue among DMUs, in such a way that the relative efficiencies of all DMUs remain unchanged and the allocations should reflect the relative efficiencies and the input-output scales of individual DMUs. To illustrate our methods, numerical results for an example are described in this paper. 相似文献
156.
An optimization approach for the determination of open boundary conditions for Computational Fluid Dynamics is introduced, whereas the error between the solution σ and interior observations ω is minimized. The numerical weather prediction (NWP) model ALADIN–Austria provides data of wind speed and wind direction at virtual weather stations within the area of interest. Also, data from real weather stations and other sources can be incorporated into the model, respectively. In this work, the optimization method is applied to the constant density Navier–Stokes Equations. Thereby, for stabilizing the ill-posed pseudo inverse problem several regularization methods are reviewed. Further, numerical studies are carried out to identify the supreme regularization method for the presented application. Finally, the algorithm is applied to the micro- and meso-scale flow over the Grimming mountain, Austria. The results are compared with real weather station data and show suitable correlation with the measurements. 相似文献
157.
Shahriar Afandizadeh Mahmud Ameri Mohammad Hassan Mirabi Moghaddam 《Applied Mathematical Modelling》2011
In this paper, a new optimization method has been proposed for accident prediction non-linear models. This has been achieved by eliminating the Hessian matrix from the equation of optimal pace length in the gradient vector method. One advantage is that it is independent of the starting point in optimization processes and it provides convergence at the highest top as well. This method has been tested on an accident prediction model and its preference over the gradient vector method has been proven. 相似文献
158.
徐惠芳 《数学年刊A辑(中文版)》2011,32(2):141-160
对一类偏积分-微分方程中参数校准的反问题进行研究.在弱解的框架下,原问题可转化为含具体正则化项的最优化问题.文中证明了该最优化问题的解的存在性和稳定性,并考察了最优解存在的一阶必要条件.另外,证明了当正则化参数足够大时,该最优化问题关于参数a的凸性性质.基于偏积分-微分方程反问题的研究对于金融市场中的模型校准问题具有重要的意义. 相似文献
159.
The chromatographic dimensionality was recently proposed as a measure of retention time spacing based on a power law (fractal) distribution. Using this model, a statistical overlap theory (SOT) for chromatographic peaks is developed that estimates the number of peak maxima as a function of the chromatographic dimension, saturation and scale. Power law models exhibit a threshold region whereby below a critical saturation value no loss of peak maxima due to peak fusion occurs as saturation increases. At moderate saturation, behavior is similar to the random (Poisson) peak model. At still higher saturation, the power law model shows loss of peaks nearly independent of the scale and dimension of the model. The physicochemical meaning of the power law scale parameter is discussed and shown to be equal to the Boltzmann-weighted free energy of transfer over the scale limits. The scale is discussed. Small scale range (small β) is shown to generate more uniform chromatograms. Large scale range chromatograms (large β) are shown to give occasional large excursions of retention times; this is a property of power laws where "wild" behavior is noted to occasionally occur. Both cases are shown to be useful depending on the chromatographic saturation. A scale-invariant model of the SOT shows very simple relationships between the fraction of peak maxima and the saturation, peak width and number of theoretical plates. These equations provide much insight into separations which follow power law statistics. 相似文献
160.
This work presents a method to optimize multi-product chromatographic systems with multiple objective functions. The system studied is a neodymium, samarium, europium, gadolinium mixture separated in an ion exchange chromatography step. A homogeneous Langmuir Mobile Phase Modified model is calibrated to fit the experiments, and then used to perform the optimization task. For the optimization a multi-objective Differential Evolution algorithm was used, with weighting based on relative value of the components to find optimal operation points along the Pareto front. The objectives of the Pareto front are weighted productivity and weighted yield with purity as an equality constraint. A prioritizing scheme based on relative values is applied for determining the pooling order. A simple rule of thumb for pooling strategy selection is presented. The multi-objective optimization gives a Pareto front which shows the rule of thumb, as a gap in one of the objective functions. 相似文献