全文获取类型
收费全文 | 1632篇 |
免费 | 35篇 |
国内免费 | 27篇 |
专业分类
化学 | 393篇 |
晶体学 | 1篇 |
力学 | 101篇 |
综合类 | 3篇 |
数学 | 865篇 |
物理学 | 331篇 |
出版年
2023年 | 25篇 |
2022年 | 43篇 |
2021年 | 18篇 |
2020年 | 30篇 |
2019年 | 18篇 |
2018年 | 19篇 |
2017年 | 27篇 |
2016年 | 27篇 |
2015年 | 33篇 |
2014年 | 57篇 |
2013年 | 94篇 |
2012年 | 155篇 |
2011年 | 105篇 |
2010年 | 65篇 |
2009年 | 120篇 |
2008年 | 108篇 |
2007年 | 96篇 |
2006年 | 67篇 |
2005年 | 32篇 |
2004年 | 37篇 |
2003年 | 53篇 |
2002年 | 20篇 |
2001年 | 22篇 |
2000年 | 18篇 |
1999年 | 17篇 |
1998年 | 34篇 |
1997年 | 22篇 |
1996年 | 29篇 |
1995年 | 20篇 |
1994年 | 19篇 |
1993年 | 17篇 |
1992年 | 13篇 |
1991年 | 16篇 |
1990年 | 15篇 |
1989年 | 10篇 |
1988年 | 12篇 |
1987年 | 8篇 |
1986年 | 13篇 |
1985年 | 25篇 |
1984年 | 20篇 |
1983年 | 15篇 |
1982年 | 23篇 |
1981年 | 16篇 |
1980年 | 11篇 |
1979年 | 11篇 |
1978年 | 25篇 |
1977年 | 5篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1967年 | 1篇 |
排序方式: 共有1694条查询结果,搜索用时 187 毫秒
141.
This paper investigates a resources-limited situation in the event-triggered model predictive control (ETMPC) for continuous-time nonlinear system with first-order hold fashion. In consideration of limited bandwidth in data transmission through wireless network under actual operation, our strategy divides the prediction horizon, and applies linear interpolation instead of zero-order hold fashion to obtain a better system performance, so that the reduction of resources and the optimization of strategy can be guaranteed. Furthermore, in actual industry processes, quadratic cost function cannot be implemented in all operations, then general cost function is adopted in this paper. Based on the first-order hold method and general cost function, the feasibility of the ETMPC algorithm and the stability of dynamical systems are analyzed. At last, a practical example is given to show the advantages of our method. 相似文献
142.
The coexistence of radar-sensing and communication systems research has received a surge of interest in recent times to tackle the issue of spectrum inadequacy. Designing an optimized radar waveform for a coexistence scenario has been a challenging task for accomplishing the convergence of radar-sensing and communication functionalities, without degrading the performance at either end. This paper proposes a novel global optimization-based Spatial Branch and Bound (SBnB) approach to optimize the phase coefficients of a Non-Linear Frequency Modulated (NLFM) waveform in a CRCS framework. In addition, the Modified-Power Ratio Constraint-Cramér–Rao Lower Bound (M-PRC-CRLB), a local optimization-based approach is proposed to optimize the phase coefficients of an NLFM waveform. The spectral energy distribution and auto-correlation characteristics of an NLFM waveform are comprehensively investigated for various values of polynomial order (N) and at different threshold Signal-to-Noise-Ratio (SNR) values. To compare the proposed waveform design approaches (M-PRC-CRLB, SBnB) with the existing waveform design approaches namely, Minimum Estimation Error Variance (MEEV) and PRC- CRLB, a Peak-to-Side-Lobe-Ratio (PSLR), and Integrated-Side-Lobe-Ratio (ISLR) are evaluated at various polynomial orders and threshold SNR values. Furthermore, the performance of a CRCS is assessed using the radar estimation rate and communication data rate. The simulation results reveal that the proposed optimized radar waveform design approaches provide improved performance compared to the existing radar waveform design approaches in terms of radar estimation rate. Further, the proposed global optimization-based SBnB approach achieves a comparable performance of the communication data rate. In addition, the proposed approaches accomplish enhanced spectral utilization, controlled side-lobe energy levels, reduced range-domain ambiguities, and a higher information rate in a CRCS. 相似文献
143.
The rapid time variations and large channel estimation errors in underwater acoustic (UWA) channels mean that transmitters for adaptive resource allocation quickly become outdated and provide inaccurate channel state information (CSI). This results in poor resource allocation efficiency. To address this issue, this paper proposes an optimization approach for imperfect CSI based on a Gauss–Markov model and the per-subcarrier channel temporal correlation (PSCTC) factor. The proposed scheme is applicable to downlink UWA orthogonal frequency division multiple access systems. The proposed PSCTC factors are measured, and their long-term stability is verified using data recorded in real-world sea tests. Simulation and experimental results show that the optimized CSI effectively mitigates the effects of the temporal variability of UWA channels. It demonstrates that the resource allocation scheme using optimized CSI achieves a higher effective throughput and a lower bit error rate than both imperfect CSI and the CSI predicted by the recursive least-squares (RLS) algorithm. 相似文献
144.
The musculo-skeletal system serves the mechanical function of creating motion and transmitting loads. It is made up mainly of four components: bone, cartilage, muscle and fibrous connective tissue. These have evolved over millions of years into the complex and diverse shapes of the animal skeleton. The skeleton, however, is not built to a static plan: it can adapt to mechanical forces during growth, it can remodel if the forces change, and it can regenerate if it is damaged. In this paper, the regulation of skeletal construction by mechanical forces is analyzed from both ontogenetic and phylogenetic standpoints. In the first part, models of biomechanical processes that act during skeletal ontogenesis – tissue differentiation and bone remodeling – are presented and, in the second, the evolution of the middle ear is used as an example of biomechanical change in skeletal phylogenesis. Because the constitutive laws for skeletal tissues are relatively well understood, and because the skeleton is preserved in the fossil record, application of mechanics to skeletal evolution seems to present a good opportunity to explore the relationships governing ontogenetic adaptations and phylogenetic change. 相似文献
145.
当前虽然已有考虑桩筏非线性的设计,但仍无人在此基础上,考虑上部结构。因此考虑上部结构,进一步认识其与桩筏基础非线性共同作用机理,优化桩筏基础设计,具有重要的现实意义。本文以子结构法凝聚上部结构的荷载及刚度,以平面壳体单元模拟筏板,按有限层法模拟桩土之间的弹性相互作用,用广义剪切位移法模拟桩的非线性工作性状,建立了一种考虑上部结构共同作用的桩筏基础非线性分析方法,并编制了分析程序。通过实例分析,探讨了上部结构与桩筏基础非线性共同作用的机理,研究了合理布桩方式,探讨了以差异沉降为目标的优化设计的可能途径。 相似文献
146.
The aim of the present paper is to study the effects of non-linear devices on the reliability-based optimal design of structural systems subject to stochastic excitation. One-dimensional hysteretic devices are used for modelling the non-linear system behavior while non-stationary filtered white noise processes are utilized to represent the stochastic excitation. The reliability-based optimization problem is formulated as the minimization of the expected cost of the structure for a specified failure probability. Failure is assumed to occur when any one of the output states of interest exceeds in magnitude some specified threshold level within a given time duration. Failure probabilities are approximated locally in terms of the design variables during the optimization process in a parallel computing environment. The approximations are based on a local interpolation scheme and on an efficient simulation technique. Specifically, a subset simulation scheme is adopted and integrated into the proposed optimization process. The local approximations are then used to define a series of explicit approximate optimization problems. A sensitivity analysis is performed at the final design in order to evaluate its robustness with respect to design and system parameters. Numerical examples are presented in order to illustrate the effects of hysteretic devices on the design of two structural systems subject to earthquake excitation. The obtained results indicate that the non-linear devices have a significant effect on the reliability and global performance of the structural systems. 相似文献
147.
Capillary electrophoresis for rapid identification of monoclonal antibodies for routine application in hospital
下载免费PDF全文
![点击此处可从《Electrophoresis》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Emmanuel Jaccoulet Claire Smadja Patrice Prognon Myriam Taverna 《Electrophoresis》2015,36(17):2050-2056
mAbs are widely used in cancer therapy. Their compounding, performed just before their administration to patients, is executed in a production unit of the hospital. Identification of these drugs, individually prepared in bags for infusion before patient administration, is of paramount importance to detect potential mistakes during compounding stage. A fast and reliable analytical method based on CZE combined to a cationic capillary coating (hexadimethrine bromide) was developed for identification of the most widely used compounded therapeutic for cancer therapy (bevacizumab, cetuximab, rituximab, and trastuzumab). Considering the high structural and physico‐chemical similarities of these mAbs, an extensive optimization of the BGE composition has been performed. The addition of perchlorate ions and polysorbate in the BGE greatly increased the resolution. To validate the method, an internal standard was used and the relative migration times (RTm) were estimated. Very satisfactory RSDs of the RTm for rituximab (0.76%), cetuximab (0.46%), bevacizumab (0.31%), and trastuzumab (0.60%) were obtained. The intraday and interday RSD of the method were less than 0.32 and 1.3%, respectively for RTm. Significant differences between theses RTms have been demonstrated allowing mAbs identification. Finally, accurate mAbs identification has been demonstrated by a blind test. 相似文献
148.
João M. Leça Ana C. Pereira Ana C. Vieira Marco S. Reis José C. Marques 《Analytica chimica acta》2015
Vicinal diketones, namely diacetyl (DC) and pentanedione (PN), are compounds naturally found in beer that play a key role in the definition of its aroma. In lager beer, they are responsible for off-flavors (buttery flavor) and therefore their presence and quantification is of paramount importance to beer producers. Aiming at developing an accurate quantitative monitoring scheme to follow these off-flavor compounds during beer production and in the final product, the head space solid-phase microextraction (HS-SPME) analytical procedure was tuned through experiments planned in an optimal way and the final settings were fully validated. Optimal design of experiments (O-DOE) is a computational, statistically-oriented approach for designing experiences that are most informative according to a well-defined criterion. This methodology was applied for HS-SPME optimization, leading to the following optimal extraction conditions for the quantification of VDK: use a CAR/PDMS fiber, 5 ml of samples in 20 ml vial, 5 min of pre-incubation time followed by 25 min of extraction at 30 °C, with agitation. The validation of the final analytical methodology was performed using a matrix-matched calibration, in order to minimize matrix effects. The following key features were obtained: linearity (R2 > 0.999, both for diacetyl and 2,3-pentanedione), high sensitivity (LOD of 0.92 μg L−1 and 2.80 μg L−1, and LOQ of 3.30 μg L−1 and 10.01 μg L−1, for diacetyl and 2,3-pentanedione, respectively), recoveries of approximately 100% and suitable precision (repeatability and reproducibility lower than 3% and 7.5%, respectively). The applicability of the methodology was fully confirmed through an independent analysis of several beer samples, with analyte concentrations ranging from 4 to 200 g L−1. 相似文献
149.
150.
Julien Gigault John M. PettiboneAuthor Vitae Charlène SchmittAuthor VitaeVincent A. Hackley 《Analytica chimica acta》2014
This tutorial proposes a comprehensive and rational measurement strategy that provides specific guidance for the application of asymmetric-flow field flow fractionation (A4F) to the size-dependent separation and characterization of nanoscale particles (NPs) dispersed in aqueous media. A range of fractionation conditions are considered, and challenging applications, including industrially relevant materials (e.g., metal NPs, asymmetric NPs), are utilized in order to validate and illustrate this approach. We demonstrate that optimization is material dependent and that polystyrene NPs, widely used as a reference standard for retention calibration in A4F, in fact represent a class of materials with unique selectivity, recovery and optimal conditions for fractionation; thus use of these standards to calibrate retention for other materials must be validated a posteriori. We discuss the use and relevance of different detection modalities that can potentially yield multi-dimensional and complementary information on NP systems. We illustrate the fractionation of atomically precise nanoclusters, which are the lower limit of the nanoscale regime. Conversely, we address the upper size limit for normal mode elution in A4F. The protocol for A4F fractionation, including the methods described in the present work is proposed as a standardized strategy to realize interlaboratory comparability and to facilitate the selection and validation of material-specific measurement parameters and conditions. It is intended for both novice and advanced users of this measurement technology. 相似文献