Comparison of structure fingerprint and molecular interaction field based methods in explaining biological similarity of small molecules in cell-based screens

In this work, we calculated the pair wise chemical similarity for a subset of small molecules screened against the NCI60 cancer cell line panel. Four different compound similarity calculation methods were used: Brutus, GRIND, Daylight and UNITY. The chemical similarity scores of each method were related to the biological similarity data set. The same was done also for combinations of methods. In the end, we had an estimate of biological similarity for a given chemical similarity score or combinations thereof. The data from above was used to identify chemical similarity ranges where combining two or more methods (data fusion) led to synergy. The results were also applied in ligand-based virtual screening using the DUD data set. In respect to their ability to enrich biologically similar compound pairs, the ranking of the four methods in descending performance is UNITY, Daylight, Brutus and GRIND. Combining methods resulted always in positive synergy within a restricted range of chemical similarity scores. We observed no negative synergy. We also noted that combining three or four methods had only limited added advantage compared to combining just two. In the virtual screening, using the estimated biological similarity for ranking compounds produced more consistent results than using the methods in isolation.     

To ask or not to ask,that is the question

Applicants for credit have to provide information for the risk assessment process. In the current conditions of a saturated consumer lending market, and hence falling “take” rates, can such information be used to assess the probability of a customer accepting the offer?     

Measuring the performance of manufacturing firms with super slacks based model of data envelopment analysis: An application of 500 major industrial enterprises in Turkey

Data envelopment analysis (DEA) is a mathematical programming technique which has a wide application area. There are many applications of DEA to measure firms’ performance. Balance sheet data is frequently used in order to measure performance of firms through DEA. So it is the characteristic of balance sheets that assets and liabilities amount to the same value. When the data for inputs and outputs are selected from both assets and liabilities sections of the balance sheet, it is important that more attention be paid to the analysis since values assigned to inputs and outputs could be included in assets and liabilities at the same time. Such a situation could create problems concerning the conclusions drawn as a result of analysis.     

高速粒子场同轴Fraunhofer全息数据处理系统研究

介绍了用同轴Fraunhofer全息测量强动载下材料表面微喷射粒子场的数据处理方法.在全息像重建过程中，将再现的三维粒子场由计算机控制分成许多小薄层采集.在数据处理过程中根据图像中粒子边缘，决定在整幅图或局部采用边缘检测的方法提取大粒子，根据图像的灰度分布将图像分成很多小区域，在每个小区域采用不同的阈值分割图像.在处理结果的校正中根据粒子场的特点，去除过大、过小和重复统计粒子.采用该方法得到了粒子的空间分布图像及粒子大小的统计结果.     

Influence of Data Acquisition Environment on Accuracy of Acoustic Voice Quality Measurements

Accuracy of acoustic voice analysis is influenced by the quality of recording. Lately, articles have suggested that soundcards perform equivalently to specialized professional-grade data acquisition (DA) systems. The purpose of this study was to investigate the influence of DA environment (DA system and microphone) on acoustic voice quality measurement (VQM) while balancing for gender, age, intersubject and intrasubject variability, and analysis software. More specifically, the relative performance of different hardware environments and the relationship between their technical characteristics and VQM performance was investigated. The discretization error and the effective dynamic range of the different DA environments were measured. We used 3 software systems to record and measure separately 2000 acoustic samples of sustained phonation for fundamental frequency, jitter, and shimmer. Analyses of variance (ANOVA) were performed with these parameters as the dependent variables. The results of the study suggested that professional-grade DA hardware is strongly recommended to provide accurate and valid voice assessment. The fundamental frequency measurement differences across DA environments were highly correlated to the discretization error (r=1.00), whereas jitter and shimmer were highly correlated to the effective dynamic range of the DA environments (r=-0.68 and r=-0.86, respectively).     

应用计算机模式识别技术研究微量元素与健康的关系

介绍了微量元素检测数据的一般统计方法，着重推荐应用计算机模式识别技术统计数据．文中介绍计算机模式识别技术的原理和作者应用该技术在微量元素科学的研究中取得的部分成果．     

矩形域上散乱数据多元最优插值的误差估计及其超收敛性（Ⅰ）──带连续边界条件

本文我们讨论了矩形域上带连续边界条件的一类多元散乱数据最优插值。给出了某些情形插值的误差估计，误差估计表明在某些点上还具有超收敛性。     

水声信道线性均衡的研究

本文在对LMS和稀疏权自适应均衡算法进行分析的基础上，将其引入到水声数据传输中，利用LMS算法对时不变信道和慢变信道进行了仿真实验；利用稀疏权自适应均衡算法对深海信道进行了仿真实验，并获得了仿真结果。     

Vapour pressures and excess functions of N, N, N′, N′-tetramethylalkanediamine + cyclohexane. A group contribution study of the N---N proximity effect

The vapour pressuresof liquid cyclohexane + N, N, N′, N′-tetramethylalkanediamine, (CH₃)₂ N(CH₂)_uN(CH₃)₂ (u = 1,2) + cyclohexane mixtures were measured by a static method between 303.15 and 343.15 K at 10 K intervals. The excess molar enthalpies at 303.15 K were also measured.

The molar excess Gibbs energies, calculated from the vapour-liquid equilibrium data, and the molar excess enthalpies compare satisfactorily with group contribution (DISQUAC) predictions.

The proximity effect of N atoms produces a regular decrease of the interactional parameters.     

A multi-objective-ACO-based data association method for bearings-only multi-target tracking

The study is concerned with data association of bearings-only multi-target tracking using two stationary observers in a 2-D scenario. In view of each target moving with a constant speed, two objective functions, i.e., distance and slope differences, are proposed and a multi-objective-ant-colony-optimization-based algorithm is then introduced to execute data association by minimizing the two objective functions. Numerical simulations are conducted to evaluate the effectiveness of the proposed algorithm in comparison with the data association results of the joint maximum likelihood (ML) method under different noise levels and track figurations.