Crystallization-induced asymmetric transformation. Application to conjugate addition of benzylamine to amides of benzoylacrylic acid

Adducts of the conjugate addition of benzylamine to enantiopure amides of aroylacrylic acid possess high enantiomeric and diastereomeric purity. A high degree of stereoselectivity has been achieved by means of crystallization-induced asymmetric transformation. A practical synthesis leading to dipeptides containing homophenylalanine is depicted.     

承受拉-扭组合载荷的薄壁圆筒屈服时产生塑性流动的条件

提出了在无外力作功的情况下，具有Bauschinger效应的弹塑性材料处于屈服状态产生自发的塑性流动时应满足的条件．这个条件不仅与材料的力学性能有关，而且还处决于材料的具体的载荷边界条件和变形．举例说明了承受拉一扭组合的薄壁圆筒中，采用组合强化模型时，产生塑性流动的具体条件．     

The first encapsulation of hydroxynitrile lyase from Hevea brasiliensis in a sol-gel matrix

A straightforward process for the encapsulation of HbHNL under low methanol conditions has been developed. By adding a sol, prepared by hydrolysis of TMOS/MTMS at pH 2.8 with continuous removal of methanol, to a stirred solution of the enzyme in a buffer at pH 6.5, at least 65% of the activity of the free enzyme could be recovered after the encapsulation. The aquagels were successfully used in the synthesis of (S)-cyanohydrins.     

冲击载荷下剪切断裂研究

利用Hopkinson压杆技术对单边平行双裂纹试样倒向加载，在较大的加载率范围，对Ti6Al4V钛合金和40CrNiMoA两种材料的动态剪切断裂行为进行了研究．实验结果表明：存在两类韧性剪切断裂模式，即常规的韧性剪切型断裂和绝热剪切断裂．常规剪切型断裂模式的断裂韧性KⅡd随加载率的提高而增大，而绝热剪切型的断裂韧性KⅡd则随加载率的提高而减小，并且，当加载率增大至某一临界值时，常规的韧性剪切断裂模式将转变为绝热剪切断裂破坏模式．     

Whirling frequencies and amplitudes due to deviations of generator shape

Earlier measurements in large synchronous generators indicate the existence of backward whirling motion, and also relatively large deviations of shape in both the rotor and the stator. These non-symmetric geometries produce an attraction force between the rotor and the stator, called unbalanced magnetic pull (UMP). The target of this paper is to analyse the whirling frequencies and amplitude of the response for large synchronous generators with a high number of poles, due to deviations of shape in the rotor and stator. A mathematical model is developed to describe the shapes of the rotor and stator, and the corresponding UMP is obtained by using the law of energy conservation. The UMP is analysed due to different deviations of shape. The result gives the average angular frequency and the magnitude of the UMP for certain deviations of shape. From this result, the whirling frequency and the amplitude of the corresponding response can be approximated. Simulations of the response of a Jeffcott rotor model show good agreement with the theoretical results of the UMP for some generator geometries. The conclusion is that different whirling frequencies, both backward and forward whirling, can occur in these machines due to deviations in shape of the generator. Therefore, the shape of the generator can excite resonance vibrations on several other frequencies than the rotation frequency. During maintenance of hydropower generators the shapes of the rotor and stator are frequently measured. The results from this paper can be used to evaluate such measurements and to explain the existence of complicated whirling motion.     

Enantioselective spiro ene-carbocyclization of 1,6-enynes catalyzed by tropos rhodium(I) complex with skewphos ligand

A tropos rhodium(I) complex having skewphos ligand is shown to be a highly enantioselective catalyst for asymmetric ene-type carbocyclization of 1,6-enynes with tri-substituted olefins to control quaternary stereogenic centers or spiro-rings.     

A 3D-BPP approach for optimising stowage plans and terminal productivity

This paper addresses the problem of determining stowage plans for containers in a ship, that is the so-called master bay plan problem (MBPP).     

直线加速器驻波腔中的瞬态束流负载效应

在高能加速器中, 随着单个束团和束团串中电荷量的提高, 当粒子束穿过加速腔的时候, 感应出的瞬态束流负载电压也越来越高. 但是, 在通常分析束流负载的时候, 往往对稳态束流负载研究的比较多, 而对瞬态束流负载的研究要相对少一些. 本文首先对束流负载的瞬态特性和束团穿过加速腔时高频源所看到谐振腔谐振频率的变化方式进行了分析, 然后又对两种情况下谐振腔的最优失谐条件进行了讨论, 并给出了相应的解析公式. 在第1种情况下, 当粒子束穿过加速腔的时候, 谐振腔的自然谐振频率能够及时地得到调节, 从而使高频源的电流与谐振腔的腔压同相, 以提高高频源的效率; 在第2种情况下, 当粒子束穿过加速腔的时候, 谐振腔的自然谐振频率保持不变, 不能被调节. 最后, 还对BEPCⅡ现有预注入器的预聚束腔、BEPCⅡ未来预注入器的两个次谐波聚束腔中的瞬态束流负载效应进行了分析.     

N-α-Benzyloxyacetyl derivatives of (S)-4-benzyl-5,5-dimethyloxazolidin-2-one for the asymmetric synthesis of differentially protected α,β-dihydroxyaldehydes

α-Dibenzylamino- and α-benzyloxy- derivatives of N-acetyl-(S)-4-benzyl-5,5-dimethyloxazolidin-2-one readily undergo highly stereoselective boron mediated syn-aldol reactions with a range of aromatic and aliphatic aldehydes, generating the syn-aldol products in good to excellent yields as single diastereoisomers after purification. In the α-dibenzylamino series, deprotection of the functionalised aldol fragments to the corresponding α-amino-β-hydroxy methyl ester or α-amino-β-hydroxyaldehyde proved problematic, with a range of N- and O-protecting groups giving mixtures of products arising from endocyclic and exocyclic cleavage pathways. However, in the α-benzyloxy series, O-silyl protection of the aldol products, and subsequent DIBAL reduction gives stereoselectively the corresponding N-1′-hydroxyalkyloxazolidin-2-ones, which undergo base promoted fragmentation to the desired highly functionalised and differentially protected α,β-dihydroxyaldehydes in good yields and without loss of stereochemical integrity.     

非螯合型手性双膦铑对脱氢苯丙氨酸的不对称催化加氢反应

报道从Ｄ－甘露醇出发合成手性双膦（２Ｓ，５Ｓ）－３，６－双（二苯膦）－１，４：３，６－双脱水－２，５－双去氧－Ｌ－艾杜醇，原位下ＢＤＰＩ与３种铑配合物作用生成手性非螯合型双膦铑催化剂，常压下对４种脱氢苯丙氨酸衍生物进行不对称催化化反主尖，对反应结果及ｅ．ｅ．值进行了讨论。