疾病传播与级联失效相互作用的研究:度不相关网络中疾病扩散条件的分析

在网络科学中,对疾病传播和级联失效的研究分属两个独立的领域,但在实际中存在许多两个过程相互耦合的情况. 比如在通信网络中,病毒传播会对数据传输造成影响,导致网络中负载变化,进而可能引发级联失效. 这个现象已被观察到. 通过建立两个动态过程相互作用的模型及针对该模型的分析,本文给出了计入节点的负载和容量时疾病爆发的条件. 这一条件是由描述疾病传播速率的传播概率与描述节点容量大小的冗余系数共同决定的. 进一步探讨表明,当疾病传播速率一定而冗余系数变化时,疾病恰好开始传播的临界点附近未感染且未失效的节点的数量是最大的,即在此点上网络处于最佳工作状态. 因此给出疾病爆发的临界条件具有重要意义. 关键词： 复杂网络 疾病传播 级联失效     

Effects of multiple blade interaction on the containment of blade fragments during a rotor failure

A finite element analysis is used to study the impact and the containment aspects of rotor blade fragments that are produced during a aircraft jet engine rotor failure. The impact and containment studies are performed on a ring-type containment structure and various fragment types are considered in this study. For each type of fragment, the ring thickness is varied incrementally and the ring response, residual kinetic energy level of the fragments, magnitude of impact forces and the overall containment or failure are determined. First, only a single fragment is considered and the rotor is assumed to contain no other blades. Next, the remaining blades are introduced and the effects of multiple collisions with the other blades on the containment are analyzed. The explicit, nonlinear finite element code Dyna3d is used for the numerical computations in this study and the results are compared with the experimental results performed on a T58 rotor at the spin facility of the Naval Air Propulsion Test Center.     

简支矩形复合材料薄板压缩屈曲后的极限强度

本文通过283块简支矩形玻璃钢薄板的压缩屈曲后极限强度的试验,证明了复合材料薄板在屈曲失稳后仍能继续承载,以玻璃钢为例,可以超过临界载荷的十几倍。文中对薄板的极限强度进行了大挠度和小挠度理论分析,结合复合材料的能量强度理论,最后得出有关极限强度计算公式的C参数曲线,对于45°方向的薄板与试验结果较符合,对于经纬向薄板当β<0.11时比试验结果略大。文中给出的C参数可供产品设计时参考。     

化学竞赛选手失利体验的心理学分析与启示——基于教育现象学的个案研究

采用现象学研究方法,通过研究一名化学竞赛选手失利时的心理体验,了解竞赛选手的参赛动机、参赛心态、学习兴趣、学习压力等方面问题,进而探寻其教育意义。对学科竞赛与资优生培养得出一些思考与启示。     

Design,synthesis and biological evaluation of pyridyl substituted benzoxazepinones as potent and selective inhibitors of aldosterone synthase

Exorbitant aldosterone is closely associated with various severe diseases, including congestive heart failure and chronic kidney disease. As aldosterone synthase is the pivotal enzyme in aldosterone biosynthesis, its inhibition constitutes a promising treatment for these diseases. Via a structure-based approach, a series of pyridyl substituted 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-ones were designed as inhibitors of aldosterone synthase. Six compounds (5j, 5l, 5m 5w, 5x and 5y) distinguished themselves with potent inhibition (IC₅₀ <100 nmol/L) and high selectivity over homogenous 11β-hydroxylase. As the most promising compound, 5x exhibited an IC₅₀ of 12 nmol/L and an excellent selectivity factor (SF) of 157, which are both superior to those of the reference fadrazole (IC₅₀ = 21 nmol/L, SF = 7). Importantly, 5x showed no inhibition against steroidogenic CYP17, CYP19 and a panel of hepatic CYP enzymes indicating an outstanding safety profile. As it manifested satisfactory pharmacokinetic properties in rats, compound 5x was considered as a drug candidate for further development.     

Synthesis of Active Metabolites of Carvedilol,an Antihypertensive Drug

A simple synthetic route for active metabolites of carvedilol is reported. The metabolites 4′-hydroxycarvedilol and 5′-hydroxycarvedilol have exhibited high activity for β-blockade. We have disclosed syntheses of 4′-hydroxycarvedilol and 5′-hydroxycarvedilol from commercially available vanillin and isovanillin, respectively.     

Characterizing fracture energy of proton exchange membranes using a knife slit test

Pinhole formation in proton exchange membranes (PEM) may be caused by a process of flaw formation and crack propagation within membranes exposed to cyclic hygrothermal loading. Fracture mechanics can be used to characterize the propagation process, which is thought to occur in a slow, time‐dependent manner under cyclic loading conditions, and believed to be associated with limited plasticity. The intrinsic fracture energy has been used to characterize the fracture resistance of polymeric material with limited viscoelastic and plastic dissipation, and has been found to be associated with long‐term durability of polymeric materials. Insight into this limiting value of fracture energy may be useful in characterizing the durability of proton exchange membranes, including the formation of pinhole defects. In an effort to collect fracture data with limited plasticity, a knife slit test was adapted to measure fracture energies of PEMs, resulting in fracture energies that were two orders of magnitude smaller than those obtained with other fracture test methods. The presence of a sharp knife blade reduces crack tip plasticity, providing fracture energies that may be more representative of the intrinsic fracture energies of the thin membranes. Three commercial PEMs were tested to evaluate their fracture energies (G_c) at temperatures ranging from 40 to 90 °C and humidity levels varying from dry to 90% relative humidity (RH). Experiments were also conducted with membrane specimens immersed in water at various temperatures. The time temperature moisture superposition principle was applied to generate fracture energy master curves plotted as a function of reduced cutting rate based on the humidity and temperature conditions of the tests. The shift with respect to temperature and humidity suggests that the slitting process is viscoelastic in nature. Also such shifts were found to be consistent with those obtained from constitutive tests such as stress relaxation. The fracture energy is more sensitive to temperature than on humidity. The master curves converge at the lowest reduced cutting rates, suggesting similar intrinsic fracture energies; but diverge at higher reduced cutting rates to significantly different fracture energies. Although the relationship between G_c and ultimate mechanical durability has not been established, the test method may hold promise for investigating and comparing membrane resistance to failure in fuel cell environments. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 333–343, 2010     

Machine learning as an online diagnostic tool for proton exchange membrane fuel cells

Proton exchange membrane fuel cells are considered a promising power supply system with high efficiency and zero emissions. They typically work within a relatively narrow range of temperature and humidity to achieve optimal performance; however, this makes the system difficult to control, leading to faults and accelerated degradation. Two main approaches can be used for diagnosis, limited data input which provides an unintrusive, rapid but limited analysis, or advanced characterisation that provides a more accurate diagnosis but often requires invasive or slow measurements. To provide an accurate diagnosis with rapid data acquisition, machine learning methods have shown great potential. However, there is a broad approach to the diagnostic algorithms and signals used in the field. This article provides a critical view of the current approaches and suggests recommendations for future methodologies of machine learning in fuel cell diagnostic applications.     

践行宽容失败理念 开发实验失败之教学价值

引导教师审视实验失败(失误)的教学价值,营造出宽容失败、善待挫折、鼓励成功的氛围。通过建立"错误病历"和"会诊"制度、提供实验补做条件、改进新设实验项目、建立"实验失败探索—科研训练—毕业设计"互通机制、在实验失败中寻找科研灵感并孵化研究课题等措施,初步建立起实验失败中的教学资源的开发机制。