多参量光声成像及其在生物医学领域的应用

光声成像兼具声学成像和光学成像两者的优点, 因而成为近十年来发展最迅速的生物医学成像技术之一. 本文介绍了光声成像的特点及其相对于广泛应用的光学成像技术和声学成像技术的优点; 其次, 解释了光声成像的成像原理, 在此基础上介绍了光声断层成像和光声显微镜这两种典型的光声成像方案, 并介绍了它们的技术特点; 然后, 介绍了光声成像对生物组织的生化特性、组织力学特性、血液流速分布、温度分布参数、微结构特性等多信息参量的提取能力, 及其在生物系统的结构成像、功能成像、代谢成像、分子成像、基因成像等多领域的应用; 最后, 展望了光声成像在生物医学领域的应用潜力并讨论了其局限性.     

浅谈CT

 CT(ComputedTomography)是计算机断层摄影技术的简称,它是自X射线在医学领域应用以来一个划时代的成就,是近代飞速发展的计算机技术和X射线成像检查技术相结合的产物。CT的发展历程CT图像是通过数学重建技术完成的。早在1917年,奥地利数学家J.Radon就从数学理论上证明了二维或三维物体可以通过其无限多个投影的集合唯一地重建图像。1938年德国的CabrielFrank首先在X线诊断中用光子方法进行图像重建。     

脑磁共振成像断层组合全息技术的研究

采用激光全息分层分区二步法，将一组磁共振成像片按不同层次组合成一张全息图，可在普通白炽灯下观察到清晰的三维层析透射图，以辅助医师准确，迅速地判断出患病部位的情况和位置。     

加强概括前后思维过渡的数学教学

数学学习中认识的一般程序是,在具体感知的基础上,经过抽象概括得出数学结论(概念和规律),再把数学结论应用于实际,即具体感知——抽象概括——实际应用的过程。这是学     

Diode-Pumped Self-Starting Mode-Locked Nd：YVO4 Laser with Semiconductor Saturable Absorber Output Coupler

By using a semiconductor saturable-absorber output coupler as a mode-locking device, we experimentally realized the operation of a diode-pumped passively mode-locked Nd:YVO4 laser. Stable laser pulses with duration of 2.3ps were generated at the output power of about 1W. With increasing the pump power to 9 W, the maximum mode-locked power of 1.7 W was obtained, which corresponds to a slope conversion efficiency of 44 % and opticalto-optical conversion efficiency of 19%.     

单光子发射型计算机断层成像

 单光子发射型计算机断层成像(SPECT),它与X-CT有某些相似之处,所不同的是:X-CT的X射线源位于体外,X射线透过组织时,根据不同组织对X射线的衰减值的不同,重建某断层的CT数矩阵,并用灰度来显示断层图像.     

RECONSTRUCTION OF THE ATTENUATED RADON TRANSFORM IN π-SCHEME SHORT-SCAN SPECT

In this work, the image reconstruction in π-scheme short-scan single-photon emission computed tomography （SPECT） with nonuniform attenuation is derived in its most general form when π-scheme short-scan SPECT entails data acquisition over disjoint angular intervals without conjugate views totaling to π radians. The reconstruction results are based on decomposition of Novikov＇s inversion operator into three parts bounded in the L2 sense. The first part involves the measured partial data; the second part is a skew-symmetric operator; the third part is a symmetric and compact contribution. It is showed firstly that the operators involved belong to L（L^2（B）. Furthermore numerical simulations are conducted to demonstrate the effectiveness of the developed method.     

多金属物体CT图像的金属伪影校正

针对多金属伪影的校正问题,本文通过仿真实验分析了多金属伪影的成因,并提出了一种基于投影校正的多金属伪影校正方法.该方法首先直接从投影域分割出金属区域,然后建立对金属区域投影值的校正模型,最后通过调整模型参数达到校正目的.模型以重建图像的灰度熵为目标函数,采用单纯形法迭代求解使熵最小时的校正参数.仿真和实际数据的实验结果表明,本文算法对多金属伪影的校正起到了良好的效果,且校正后的图像质量优于插值校正法.     

Pseudo-global tomography for local micro-computed tomography with high-brightness synchrotron X-rays

The computed tomography imaging of a local region inside a sample with a size larger than the field of view is particularly important for synchrotron X-ray imaging.In this letter,an improved algorithm is proposed to reconstruct the local structure inside a sample using almost completely local data.The algorithm significantly reduces the X-ray radiation dose and improves computational efficiency.Simulation results show that the new algorithm works well and has a higher reconstruction precision than previous methods,as confirmed by experimental results carried out at the Shanghai Synchrotron Radiation Facility.     

融合结构先验信息的稳态扩散光学断层成像重建算法研究

扩散光学断层成像作为一种无辐射损伤、低成本的光学在体成像技术,有着良好的应用前景,但具有空间分辨率低、难以定量的缺陷.为了提高扩散光学断层成像的分辨率,实现光学参数分布的精确重建,基于有限元方法,提出了融合结构先验信息的稳态扩散光学断层成像重建算法.该算法以扩散近似作为成像模型,通过软先验的Laplace 正则化方法引入由MicroCT提供的空间结构信息.采用伴随法计算Jacobian矩阵,Levenberg-Marquardt方法用来进行迭代优化.仿真结果表明该算法不仅能获得精确的光学参数值分布,而且显著地提高了迭代收敛的速度.