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431.
分别采用微波辐射法和加热回流的常规方法, 将1-氨基-2-(2-甲基/三氟甲基-苯并咪唑-1-亚甲基)-5-巯基-1,3,4-三唑与α-溴代芳基乙酮3a~3e反应, 合成了一系列未见文献报道的1,2,4-三唑[3,4-b]-1',3',4'-噻二嗪类化合物4a~4e 和5a~5e. 微波辐射法具有反应时间短、产率高、副反应少等优点. 标题化合物经元素分析, IR, 1H NMR, MS确证结构. 相似文献
432.
L. A. Kayukova K. M. Beketov A. L. Akhelova K. D. Praliev 《Chemistry of Heterocyclic Compounds》2006,42(7):914-917
Cyclization of O-benzoyl-2-(benzimidazol-1-yl)propioamidoxime under different temperature conditions gave 2-[2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl]benzimidazole
whose structure has been determined by X-ray analysis.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1057–1061, July, 2006. 相似文献
433.
López-Rodríguez ML Benhamú B Murcia M Alvaro E Campillo M Pardo L 《Journal of computer-aided molecular design》2003,17(8):515-524
We report a structure-affinity analysis of an important element in the pharmacophore model for the recognition of 5-HT4 receptor antagonists: the voluminous substituent attached to the basic nitrogen of the ligand. We have designed, synthesized and pharmacologically evaluated a series of benzimidazole derivatives 1 containing a common molecular skeleton formed by N-[(4-piperidyl)methyl]-6-chlorobenzimidazole-4-carboxamide and four different substituents (R = butyl, 2-[(methylsulfonyl)amino]ethyl, 5-[(phenylacetyl)amino]pentyl, and 5-[(benzylsulfonyl)amino]pentyl). These compounds possess binding affinities in the nM range (Ki = 0.11-1.50 nM). Moreover, a ligand that contains a hydrogen atom attached to the basic nitrogen (R = H; Ki = 150 nM) is used as a control for structure-affinity relationships. 相似文献
434.
435.
The reaction of Zn(ClO4)2·6H2O with 3,3'-bis(2-benzimidazolyl)-2,2'-dipyridine (L) gave a mononuclear zinc(Ⅱ) complex: [ZnL2](ClO4)2·2DMF·4H2O, which was structurally characterized by EA, IR, UV, 1H NMR, fluorescence spectrum and single-crystal X-ray diffraction. The crystal (C54H54Cl2N14O14Zn, Mr=1259.38) belongs to the monoclinic system, space group C2/c with a=20.874(2), b=14.9953(16), c=20.462(3) (A), β=101.553(2)°, V=6274.8(13) (A)3, Z=4, Dc=1.333 g/cm3, F (000)=2608, μ(MoKα)=0.548 mm-1, R=0.0682 and Wr=0.1931 for 4984 observed reflections with Ⅰ > 2σ(Ⅰ). The Zn(Ⅱ) is four-coordinated in a slightly distorted tetrahedral geometry through four N atoms from four benzimidazole units of two ligands. In the crystal lattice, the [ZnL2]2 cations are linked to each other by extensive intermolecular hydrogen bonds between nitrogen atoms of benzimidazole rings, water and DMF molecules. 相似文献
436.
A solid-phase synthesis of benzimidazole N-oxides was developed while attempting to synthesize 1,5-benzodiazepine-2,4-diones. The key step of the synthesis involves the reduction of an arylnitro to a hydroxyamino intermediate which subsequently condenses with an internal carbonyl group to give a benzimidazole N-oxide. A library of nine benzimidazole N-oxides was prepared on SynPhase™ Lanterns using this reduction-cyclization methodology. 相似文献
437.
1 INTRODUCTION Imidazole which is a part of histidine, plays an important role as a ligand in bioinorganic chemistry. Up to now, a variety of coordination compounds with imidazole ligands have been synthesized and characterized[1]. Its complexes have a… 相似文献
438.
E. Abele R. Abele P. Arsenyan S. Belyakov M. Veveris E. Lukevics 《Chemistry of Heterocyclic Compounds》2007,43(2):220-224
The reaction of 2-mercaptobenzimidazole with 1,3-dichloropropane or bis(chloromethyl)dimethylsilane in the two-phase catalytic
system of solid K2CO3-18-crown-6-toluene at 111°C leads to a selective formation of tricyclic benzimidazole sulfides in 56 and 92% yields. The
synthesized compounds were tested as hypocholesterolemic agents.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 274–279, February, 2007. 相似文献
439.
A highly yielding and fast method for the synthesis of heterocyclic compounds with trialkyl orthoformate using molecular sieve 3Å as a catalyst is described. 相似文献
440.
D. S. Zurabishvili M. O. Lomidze Sh. A. Samsoniya A. Wesquet U. Kazmaier 《Chemistry of Heterocyclic Compounds》2008,44(8):941-949
4-(1-Adamantyl)-1,2-diaminobenzene, previously unreported in the literature, has been prepared and a novel series of 5(6)-(1-adamantyl)benzimidazole
derivatives synthesized. Nitration, hydrogenation, and side chain reactions have been carried out.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1172–1182, August, 2008. 相似文献