具有电化学敏感性的超分子交联点及其水凝胶研究

本文通过主体分子环糊精（CD）和客体分子二茂铁（Fc）之间的包结络合作用,在CD稳定的CdS量子点（CD@QD）表面成功地引入了可聚合双键.所得超分子结构能够作为交联点与N,N-二甲基丙烯酰胺（DMA）单体共聚制备杂化超分子水凝胶（Fc-Gel）,称为超分子交联点（Fc-SCL）.Fc还赋予了该结构良好的电化学敏感性.随着Fc-SCL含量的增加,Fc-Gel的力学性能有所增强.此外,该凝胶还具有良好的荧光性质.实验表明,在凝胶形成过程中,CD和Fc之间的包结络合起了关键的交联作用,因此这种凝胶是一种由超分子作用诱导的有机-无机杂化水凝胶.     

黄芩苷对温敏凝胶的模板作用及其形态和性能

以黄酮类化合物黄芩苷作为功能单体,在二甲基甲酰胺溶液中制备得到不同黄芩苷含量的聚异丙基丙烯酰胺水凝胶。通过红外、紫外、扫描电镜和热分析等方法研究了所得凝胶的结构、形态、温敏性和力学性能。结果表明：黄芩苷的加入导致聚合凝胶由无色变为黄色,所得凝胶孔壁出现褶皱,孔洞尺寸随黄芩苷含量的增加而增加。黄芩苷在凝胶基体中主要起到模板作用,它的引入并未改变纯凝胶的体积相转变温度（VPTT）,VPTT仍保持在32～34°C,但温度敏感性能得到了明显改善,同时改善了纯凝胶的溶胀度和温度脉冲响应性,提高了储能模量。     

辉光放电电解等离子体引发合成丙烯酰胺-丙烯酸共聚物水凝胶及其对阳离子染料的吸附性能

以丙烯酰胺（AM）和丙烯酸（AA）为单体、N,N′-亚甲基双丙烯酰胺（MBA）为交联剂,在水溶液中利用辉光放电电解等离子体（GDEP）引发,一步制得丙烯酰胺-丙烯酸共聚物（P（AM-co-AA））水凝胶。用红外光谱（FT-IR）、扫描电镜（SEM）和热重分析（TGA）对P（AM-co-AA）水凝胶的结构、形貌和稳定性进行了表征。考察了放电电压、放电时间、MBA质量含量、AM质量分数以及中和度对P（AM-co-AA）水凝胶吸附孔雀石绿（MG）的影响,同时探讨了引发机理。结果表明,水凝胶对MG的最大吸附量为864mg/g。     

单分散CdS纳米晶/PNIPAM复合水凝胶的制备及其温敏荧光特性

采用液体-固体-溶液法(LSS)制备单分散CdS纳米晶;通过自由基聚合制备单分散CdS纳米晶/聚N-异丙基丙烯酰胺(CdS/PNIPAM)复合温敏水凝胶.采用HRTEM、XRD、FTIR、DSC、PL等对CdS纳米晶、CdS/PNIPAM温敏复合凝胶的微观结构与性能进行了表征,变温荧光光谱研究了温度对凝胶荧光性能的影响.结果表明,CdS纳米晶粒径约为2.8 nm,单分散性良好;复合凝胶的荧光发射强度与环境温度存在一定的关联性,且呈可逆性.     

抗菌淀粉-聚乙烯醇水凝胶的制备及性能

以环氧氯丙烷为键合剂将胍盐低聚物（PHMG）接枝到淀粉分子上,设计了正交试验优化接枝反应条件。将产物添加到淀粉和聚乙烯醇（PVA）水溶液中,采用化学交联法合成了具有抗菌性能的淀粉-聚乙烯醇（S-PVA）水凝胶,测试了水凝胶的溶胀率、脱水率以及抗菌性能。结果表明：当反应温度为40°C、时间为0.5 h、pH为9时,PHM...     

阳离子型温敏水凝胶的溶胀性能及其对表面活性剂的吸附行为

阳离子单体;温敏凝胶;阳离子型温敏水凝胶的溶胀性能及其对表面活性剂的吸附行为     

Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery

Nanocomposite hydrogels are one of the most important types of biomaterials which can be used in many different applications such as drug delivery and tissue engineering.Incorporation of nanoparticles within a hydrogel matrix can provide unique characteristics like remote stimulate and improved mechanical strength.In this study,the synthesis of graphene oxide and graphene oxide nanocomposite hydrogel has been studied.Nanocomposite hydrogel was synthesized using carboxymethyl cellulose as a natural base,acrylic acid as a comonomer,graphene oxide as a filler,ammonium persulfate as an initiator,and iron nanoparticles as a crosslinking agent.The effect of reaction variables such as the iron nanoparticles,graphene oxide,ammonium persulfate,and acrylic acid were examined to achieve a hydrogel with maximum absorbency.Doxorubicin,an anti-cancer chemotherapy drug,was loaded into this hydrogel and its release behaviors were examined in the phosphate buffer solutions with different pH values.The structure of the graphene oxide and the optimized hydrogel were confirmed by Fourier-transform infrared spectroscopy,Raman spectroscopy,X-ray diffraction,scanning electron microscopy,and atomic force microscopy.     

Additive‐Free Green Light‐Induced Ligation Using BODIPY Triggers

Photochemical ligation is important in biomaterials engineering for spatiotemporal control of biochemical processes. Such reactions however generally require activation by high energy UV or short wavelength blue light, which can limit their use as a consequence of the potential of these high energy light sources to damage living cells. Herein, we present an additive‐free, biocompatible, chemical ligation triggered by mild visible light. BODIPY dyes with a pendant thioether attached at the meso‐position undergo photolysis of the [C?S] bond under green light (λ=530 nm) excitation, producing an ion pair intermediate that can react specifically with a propiolate group. The utility of this photochemical ligation in materials science is demonstrated by the fabrication of hydrogels with specific architectures, photo‐immobilization of biomacromolecules, and live cell encapsulation within a hydrogel scaffold.     

A Mini Review on the Functional Biomaterials Based on Poly(lactic acid) Stereocomplex

Poly(lactic acid) stereocomplex (sc-PLA) prevails over homo-poly(lactic acid)s in many aspects and showed great potential as biomaterials depending on its extraordinary biological, thermal, and mechanical properties. In the past few years, sc-PLA has gained tremendous attention as a new approach to the development of new types of functional biomaterials. This paper summarizes recent progress in the application of the concept of sc-PLA in the design and fabrication of stabilized nanoparticles and in situ gelling hydrogels for biomedical applications.