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111.
The betain like carbodiphosphorane CO2 adduct O2CC(PPh3)2 ( 1a ) can serve as a ligand versus hard Lewis acids from main group compounds. Thus, reaction of 1a with InCl3, InI3 and SnCl2 in polar solvents leads to the addition compounds [Cl3In{O2CC(PPh3)2}] ( 2 ), [Cl2SnO2CC(PPh3)2}] ( 3 ) and the salt like compound [I2In{O2CC(PPh3)2}2]I ( 4 ) in good yields. Whereas in the indium compounds 1a acts as a chelating ligand, in the tin compound the molecule coordinates with one oxygen atom only as a monodentate ligand. 4 has a pyramidal structure with a stereochemical active pair of electrons. All compounds could be characterized by X‐ray analyses and the usual spectroscopic methods. 相似文献
112.
A stereoselective 7-endo-trig cyclisation of homopropargyl and phenyl homopropargyl derivatives of Baylis-Hillman adducts using n-Bu3SnH/AIBN mediated vinyl radical cyclisation affords tri- and tetrasubstituted oxepanes, respectively, in good yields. 相似文献
113.
C_(60)与含烯丙基胺聚合物加成物的荧光行为 总被引:1,自引:1,他引:1
C_(60)与含烯丙基胺聚合物加成物的荧光行为田慧洁,陈立桅,姚光庆,金朝霞,李福绵(北京大学化学系北京100871)关键词脂肪胺,C_(60),聚烯丙基胺,荧光C60是一高度对称的笼状碳簇分子,室温下难以观察到荧光现象[1],但我们发现它与聚烯丙基胺... 相似文献
114.
Van den Driessche B Lemière F Van Dongen W Van der Linden A Esmans EL 《Journal of mass spectrometry : JMS》2004,39(1):29-37
In a general study of DNA adduct formation with melphalan, rats were intravenously injected with a single high dose (10 mg kg(-1)). Adduct formation was studied at the nucleoside level in the target organs liver, bone marrow, kidney and blood with the use of 2D liquid chromatography/tandem mass spectrometry (LC/MS/MS). Adducts of dGuo and dAdo were detected under selected reaction monitoring in liver and bone marrow 10 h after administration of melphalan. In the DNA hydrolysates from kidney and blood a Gua-melphalan adduct was found, although in very low abundance. These first results of the search for in vivo-formed melphalan adducts in the rat showed that our miniaturized LC/MS technique is useful for investigating this type of compound. More experiments will be performed in this area to gather more information about the pharmacokinetics and the quantity of adducts formed. 相似文献
115.
Kazuhiro Yoshizawa 《Tetrahedron》2007,63(27):6259-6286
Siloxyallenes proved to be a useful functional intermediate in the preparation of (Z)-β-branched Morita-Baylis-Hillman type adducts by the reaction of aldehydes with silylacetylenes or siloxypropynes. Various (Z)-chalcones were stereoselectively synthesized from siloxypropynes via siloxyallenes. 相似文献
116.
1,3-Diaryl-2-propynyl trimethylsilyl ethers were easy to isomerize into the corresponding siloxyallenes using a catalytic amount of potassium tert-butoxide under very mild conditions. The siloxyallenes reacted in situ with various aldehydes to afford Z-selective β-branched Morita-Baylis-Hillman-type adducts in a one-pot reaction after acid treatment. 相似文献
117.
Ponnusamy Shanmugam Vadivel Vaithiyanathan Baby Viswambharan Suchithra Madhavan 《Tetrahedron letters》2007,48(52):9190-9194
The reaction of the Baylis–Hillman adduct 2 of ferrocenealdehyde with various oxygen and carbon nucleophiles in the presence of montmorillonite K10 clay catalyst furnished highly functionalised trisubstituted alkene derivatives of ferrocenealdehyde in excellent yield. Synthetic use of one of products 7 has been demonstrated with the synthesis of a 1,3-diyne ether derivative of ferrocene 16 via an Eglinton coupling reaction. 相似文献
118.
The effects of liquid chromatography mobile phase buffer contents on the ionization and fragmentation of drug molecules in liquid chromatographic/ionspray tandem mass spectrometric (LC/MS/MS) determination were evaluated for simvastatin (SV) and its hydroxy acid (SVA). The objective was to improve further the sensitivity for SV by overcoming the unfavorable condition caused by the formation of multiple major adduct ions and multiple major fragment ions when using ammonium as LC mobile phase buffer. Mobile phases (70:30 acetonitrile-buffer, 2 mM, pH 4.5) with buffers made from ammonium, hydrazine or alkyl (methyl, ethyl, dimethyl or trimethyl)-substituted ammonium acetate were evaluated. Q1 scan and product ion scan spectra were obtained for SV in each of the mobile phases under optimized conditions. The results showed that, with the alkylammonium buffers, the alkylammonium-adducted SV was observed as the only major molecular ion, while the formation of other adduct ions ([M + H](+), [M + Na](+) and [M + K](+)) was successfully suppressed. On the other hand, product ion spectra with a single major fragment ion were not observed for any of the alkylammonium-adducted SVs. The affinity of the alkylammoniums to SV and the basicity of the alkylamines are believed to be factors influencing the formation and abundance of molecular and fragment ions, respectively. Methylammonium acetate provided the most favorable condition among all the buffers evaluated and improved the sensitivity several-fold for SV in LC/MS/MS quantitation compared with that obtained using ammonium acetate buffer. Better precision for SV in both Q1 and SRM scans was observed when using methylammonium buffer compared with those using ammonium buffer. The mobile phase buffer contents did not seem to affect the ionization, fragmentation and chromatography of SVA. The results of this evaluation can be applied to similar situations with other organic molecules in ionspray LC/MS/MS determination. 相似文献
119.
120.
Fumio Toda Koichi Tanaka Thomas C. W. Mak 《Journal of inclusion phenomena and macrocyclic chemistry》1985,3(3):225-233
The title compounds crystallize in space groupC2/c withZ=4; C18H12O2Cl2·HO(CH2)4OH,a=16.186(3),b=7.626(1),c=16.939(3) Å, =91.32(2)°,R
F
=0.048 for 1743 observed MoK reflections; C26H20O2·HO(CH2)4OH,a=11.881(3),b=13.009(4),c=16.689(4) Å, =110.67(2)°,R
F
=0.066 for 1783 data points. Both structures feature centrosymmetric hydrogen-bonded (OH)4 rings formed by molecular components located in special positions. Different packing modes account for the observed conformations (g
+
ag
– andaaa, respectively) of 1,4-butanediol and its possible replacement by 1,2-ethanediol as a guest in the former crystal structure.
Supplementary Data relating to this article are deposited with the British Library as Supplementary Publication No. SUP 82009 (25 pages).Dedicated to Professor H. M. Powell. 相似文献