一类电子俘获型红外可激发材料光学性能研究

测试了硫化助熔剂法制备的电子俘获型红外可激发材料Ｅｕ，Ｓｍ∶ＣａＳ和Ｃｅ，Ｓｍ∶ＣａＳ的激发光谱、红外激励光谱、荧光光谱及红外上转换发光光谱等，结果表明：这类材料不仅具有红外上转换及光存储功能，而且具有光谱响应范围广、可在室温下工作以及造价低等优点，是一类很有发展前途的光学功能材料。     

用分子动力学模拟甲烷水合物热激法分解

用分子动力学模拟方法研究甲烷水合物热激法分解，系统地研究注入340 K液态水的结构Ⅰ型甲烷水合物的分解机理.模拟显示水合物表层水分子与高温液态水分子接触获得热能，分子运动激烈，摆脱水分子间的氢键束缚，笼状结构被破坏.甲烷分子获得热能从笼中挣脱，向外体系扩散.热能通过分子碰撞从外层传递给内层水分子，水合物逐层分解.对比注入277K液态水体系模拟结果，得出热激法促进水合物分解. 关键词： 甲烷水合物 分子动力学模拟 热激法     

A novel fluorescent aptasensor based on mesoporous silica nanoparticles for the selective detection of sulfadiazine in edible tissue

Sulfadiazine (SDZ) is a broad-spectrum antibiotic used to treat bacterial infections in animals, and SDZ residues in food can be harmful to human health. As a result, an aptasensor based on silica nanoparticles was developed for the rapid detection of SDZ. An aptamer that specifically binds to SDZ was obtained using graphene oxide-SELEX and further truncated to a 13 nt sequence (SDZ30-1:5′-AACCCAATGGGAT-3′), which has a high affinity (K_d = 65.72 nM). In addition, it was found by molecular simulation that a steric hindrance could prevent the target molecule from entering the binding pocket formed by the key base “TGG”, which affects the total binding free energy of SDZ30-1 and the target molecule, thereby affecting the affinity of SDZ30-1 to the target. The SDZ30-1 was selected as the fluorescent probe to establish an aptasensor for the detection of SDZ residues in milk and honey. The aptasensor exhibited a wide dynamic linear range (3.125 – 100 ng/mL) and a limit of detection (LOD = 1.68 ng/mL). The aptasensor in spiked samples recovered at a rate of 95.12 – 105.47%, with a coefficient of variation of less than 13.18 %. The results of aptasensor were positively correlated with those of HPLC (R² > 0.8687). Based on the above results, it could be inferred that the aptasensor can be used sensitively and rapidly for the detection of SDZ residues in edible tissue.     

用于截瘫FES行走的三维上肢力动态测量系统

功能性电刺激(FES)技术已被广泛用于截瘫病人行走能力的恢复,但作为评估截瘫FES行走效率的重要指标,三维上肢力状况的研究至今仍十分有限,亟待深入开展。本文研制出了一套可用于截瘫FES行走的三维上肢力动态测量系统,该系统在一个标准步行器框架上装备有 12个应力应变片电桥,通过专用的隔离放大及A/D转换装置与计算机相连,经过标定后,截瘫FES行走时的上肢支撑力数据就可以被系统实时获得并显示。测力系统在应变片位置的确定以及“冗余-优化”方法的采用等多个方面保证了测量的可靠性和准确性,后续的校准实验显示系统的非线性、交互干扰和力学精度误差分别小于 2. 901%, 3. 188%和 1. 01%。研究中,一例截瘫患者作为志愿者按照正常的FES行走训练程序进行了相关测试,以验证新系统在行走能力评估方面的临床前景,结果表明其可用于: 1)截瘫FES行走效率的评估; 2)病人自我训练的控制指导; 3)作为反馈信号选择一种有效的FES模式和阵列。     

Research on Driving Fatigue Alleviation Using Interesting Auditory Stimulation Based on VMD-MMSE

The accurate detection and alleviation of driving fatigue are of great significance to traffic safety. In this study, we tried to apply the modified multi-scale entropy (MMSE) approach, based on variational mode decomposition (VMD), to driving fatigue detection. Firstly, the VMD was used to decompose EEG into multiple intrinsic mode functions (IMFs), then the best IMFs and scale factors were selected using the least square method (LSM). Finally, the MMSE features were extracted. Compared with the traditional sample entropy (SampEn), the VMD-MMSE method can identify the characteristics of driving fatigue more effectively. The VMD-MMSE characteristics combined with a subjective questionnaire (SQ) were used to analyze the change trends of driving fatigue under two driving modes: normal driving mode and interesting auditory stimulation mode. The results show that the interesting auditory stimulation method adopted in this paper can effectively relieve driving fatigue. In addition, the interesting auditory stimulation method, which simply involves playing interesting auditory information on the vehicle-mounted player, can effectively relieve driving fatigue. Compared with traditional driving fatigue-relieving methods, such as sleeping and drinking coffee, this interesting auditory stimulation method can relieve fatigue in real-time when the driver is driving normally.     

基于生物条形码的粘蛋白和特定细胞电化学发光适配体生物传感方法研究

本文基于适配体识别和生物条形码放大策略,以MCF-7细胞和粘蛋白(MUC1)为目标物,MUC1的特异性适配体(rcDNA)为分子识别物质,Ru(phen)32+为信号物质,rcDNA通过巯基自组装于金电极表面作为传感界面,发卡DNA (hpDNA)和rcDNA通过巯基自组装在金纳米粒子(AuNP)表面合成的hpDNA/...     

声光双稳态系统浑沌的外周期激励控制

本文针对声光双稳系统中的浑沌态,提出了外周期激励控制方法,数值模拟表明,适当选择注入信号强度,可以实现对浑沌系统的控制.通过计算我们还分析了噪音和系统的浑沌程度对浑沌控制的影响.     

Numerical Simulation of the Influence of Rough Bone-Callus Interface on the Healing of Fractured Bone

The process of healing of fractured bone is known to be influenced by the mechanical environment and the loads exerted by physical activity of the patient or otherwise. We compute mechanical fields in the soft connective tissue of the healing fracture using Biot's poroelasticity model and a finite element (FE) method for low-frequency loading. A two-scale FE framework is used to model effects of the rough bone-callus contact surface. We look at the difference the interface roughness makes with respect to different possible mechanostimulating agents.     

Functional MRI detection of hemodynamic response of repeated median nerve stimulation

Median nerve stimulation is a commonly used technique in the clinical setting to determine areas of neuronal function in the brain. Neuronal activity of repeated median nerve stimulation is well studied. The cerebral hemodynamic response of the stimulation, on the other hand, is not very clear. In this study, we investigate how cerebral hemodynamics behave over time using the same repeated median nerve stimulation. Ten subjects received constant repeated electrical stimulation to the right median nerve. Each subject had functional magnetic resonance imaging scans while receiving said stimulations for seven runs. Our results show that the blood oxygen level-dependent (BOLD) signal significantly decreases across each run. Significant BOLD signal decreases can also be seen within runs. These results are consistent with studies that have studied the hemodynamic habituation effect with other forms of stimulation. However, the results do not completely agree with the findings of studies where evoked potentials were examined. Thus, further inquiry of how evoked potentials and cerebral hemodynamics are coupled when using constant stimulations is needed.     

大气环境下激光传输仿真软件的设计与编制

随着激光技术的发展,激光大气传输特性一直是激光领域的研究热点。综合激光大气传输的理论模型,运用科学的软件开发方法设计出了一套仿真系统,用来模拟激光在复杂大气环境中的辐射特性和激光的传输过程。该系统理论模型以Lambert-Beer定律为基础,结合了瑞利散射和米散射等经典理论,当在烟幕环境中模拟激光传输时,采用了多次散射模型。仿真中对大气环境采用逐段细化,每段根据数据库参数变化选取合适的计算模型,以提高仿真精度。绘制出了光斑和等位面随传输距离的演化图形,以演示激光大气的传输过程。