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51.
A convenient,rapid and efficient method for the synthesis of substituted steroidal[6,7-d]thiazoles using microwave-induced organic reaction enhancement chemistry has been developed.The additional features of this methodology include a much faster reaction,easy workup,high yield,high purity of the products and an environment friendly approach. 相似文献
52.
A convenient, rapid and efficient method for the synthesis of substituted steroidal [6,7-d] thiazoles using microwave-induced organic reaction enhancement chemistry has been developed. The additional features of this methodology include a much faster reaction, easy workup, high yield, high purity of the products and an environment friendly approach. 相似文献
53.
Azharullah Khan Mahboob Alam M. Mushfiq 《中国化学快报》2008,19(9):1027-1030
A convenient, rapid and efficient method for the synthesis of substituted steroidal [6,7-d] thiazoles using microwave-induced organic reaction enhancement chemistry has been developed. The additional features of this methodology include a much faster reaction, easy workup, high yield, high purity of the products and an environment friendly approach. 相似文献
54.
Kun Zou Jun‐zhi Wang Zhi‐yong Guo Ming Du Jun Wu Yuan Zhou Fei‐jun Dan Chuang Liu 《Magnetic resonance in chemistry : MRC》2009,47(1):87-91
Four new furostanol saponins (1–4), two pairs of diastereoisomers, were isolated from methanolic extracts of Tupistra chinensis rhizomes and their structures were assigned from 1H and 13C NMR spectra, DEPT, and by 2D COSY, NOESY, HMQC, and HMBC experiments. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
55.
The tuber of Ophiopogon japonicus Ker-Gawl. is recorded to have various functions, such as against cardiovascular diseases and anti-bacteria, and used as a potent drug to treat different diseases, especially heart diseases1. Since the first steriodal glycoside was isolated from the plant by Japanese scholars2, much attention has been paid to the studies of the chemical components of O. japonicus in recent decades. Steroidal glycosides as the major glycosides with the aglycones of ruscogenin … 相似文献
56.
57.
Sulekh Chandra Monika Tyagi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):778-789
A series of metal complexes of Pd(II), Pt(II), Rh(III), Ir(III), and Ru(III) with thiosemicarbazone and semicarbazone of 2-acetyl thiophene have been synthesized. Their structures were determined on the basis of elemental analyses; molar conductance; magnetic susceptibility measurements; and IR, 1 H NMR, and electronic spectral studies. On the basis of molar conductance, the complexes may be formulated as [M(L)2]Cl2 and [M′(L)2Cl2]Cl [where M = Pd(II), Pt(II) and M′ = Rh(III), Ir(III), and Ru(III)] due to their 1:2 and 1:1 electrolytic nature. On the basis of IR, 1 H NMR, and electronic spectral studies, an octahedral geometry has been assigned for Rh(III), Ir(III), and Ru(III), while square planar geometry has been assigned for the Pd(II) and Pt(II) complexes. The synthesized ligands and their complexes have been screened for bactericidal activity against several bacterial species (i.e., B. macerans, A. aureus, E. coli), and it is shown that the metal complexes act as more active antimicrobial agents than the uncomplexed ligands from which they derive. 相似文献
58.
Jelili A. Badmus Okobi E. Ekpo Jyoti R. Sharma Nicole Remaliah S. Sibuyi Mervin Meyer Ahmed A. Hussein Donavon C. Hiss 《Molecules (Basel, Switzerland)》2020,25(23)
Holamine and funtumine, steroidal alkaloids with strong and diverse pharmacological activities are commonly found in the Apocynaceae family of Holarrhena. The selective anti-proliferative and cell cycle arrest effects of holamine and funtumine on cancer cells have been previously reported. The present study evaluated the anti-proliferative mechanism of action of these two steroidal alkaloids on cancer cell lines (HT-29, MCF-7 and HeLa) by exploring the mitochondrial depolarization effects, reactive oxygen species (ROS) induction, apoptosis, F-actin perturbation, and inhibition of topoisomerase-I. The apoptosis-inducing effects of the compounds were studied by flow cytometry using the APOPercentageTM dye and Caspase-3/7 Glo assay kit. The two compounds showed a significantly greater cytotoxicity in cancer cells compared to non-cancer (normal) fibroblasts. The observed antiproliferative effects of the two alkaloids presumably are facilitated through the stimulation of apoptosis. The apoptotic effect was elicited through the modulation of mitochondrial function, elevated ROS production, and caspase-3/7 activation. Both compounds also induced F-actin disorganization and inhibited topoisomerase-I activity. Although holamine and funtumine appear to have translational potential for the development of novel anticancer agents, further mechanistic and molecular studies are recommended to fully understand their anticancer effects. 相似文献
59.
Novel spiro(3-hydroxy-5,5-dimethyl)-1,5’-(2’-substituated[1,3,4]-oxadiazole/thiadiazolo[3,2-c] thiazolines and 3-hydroxy-5,5-dimethyl-spiro[cyclohex-2-ene-thiazolo/thiazino[3,2-b]-s-tetrazine were prepared from previously reported hydrazone, semicarbazone, carbazone, and spiro-s-tetrazine intermediates derived from dimedone precursor. All the newly synthesized heterocycles have been characterized by analytical and spectral (1H NMR and hC NMR) data and screened their in vitro antibacterial activity against gram negative bacteria Escherichia coli and gram positive bacteria Staphylococcus aureus. Some of the compounds showed moderate to good activities towards the bacteria chosen. 相似文献
60.
YongHongZHANG QingYiWEI ZhongLiLIU LiYANG DongLiangCHENG 《中国化学快报》2004,15(12):1445-1447
Two new steroidal glycosides were isolated from the Chinese medicinal plant Caryopteris terniflora. The spectroscopic and chemical evidences revealed that their structures tobe 6-(β-sitosteroyl-3-O-β-glucopyranosidyl) hexacosanate 1 and 6‘-(stigmasteroyl-3-O-β-glucopy-ranosidyl) linolenate 2, respectively. 相似文献