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971.
N-甲基-2-单芳基苯并噻唑啉 (1) 在固体状态时可以稳定地储藏在空气中。但是,它们在不同溶剂中却表现出了不同的行为。在醇溶液或二甲亚砜-水的体系中,1相对稳定;而在其它有机溶剂如:丙酮,氯仿,二氯甲烷和乙酸乙酯等溶剂中,会发生自发偶联反应生成相应的邻-(N-芳酰基-N-甲氨基苯)-二硫化合物 (2)。对这些新的化合物 (1) 和 (2) 进行了体外人乳腺癌细胞 (MDA-MB-231) 血管内皮生长因子靶点筛选,大部分化合物都表现出了抑制活性。实验结果表明这两类化合物 (1) 和 (2) 作为血管内皮生长因子抑制剂值得进行深入研究。 相似文献
972.
杯[4]芳烃的上端和下端通过金属复分解闭环反应以较高产率合成一系列新型杯[4]冠醚衍生物(8a-c),目标产物结构经元素分析、IR、MS、1H NMR及13C NMR证实。 相似文献
973.
A chiral ionic liquid-catalyzed, efficient and unprecedented version of the Biginelli reaction using new variants of its active methylene component, viz. 2-phenyl-1,3-oxazol-5-one/2-methyl-2-phenyl-1,3-oxathiolan-5-one, with aromatic aldehydes and urea/thiourea enantio- and diastereoselectively, yields 5-amino-/mercaptoperhydropyrimidines. This three-component domino cyclocondensation reaction is effected via ring transformation of an isolable intermediate in a one-pot procedure. 相似文献
974.
The trifluoromethyl containing heterocycles, 2-hydroxy-4-aryl-3-(thien-2-oyl)-2-(trifluoromethyl)-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one derivatives 4, were synthesized via a one-pot three-component reaction of aldehyde 1 with 1,3-cyclohexanedione 2 and 4,4,4-trifluoro-1-(thien-2-yl)butane-1,3-dione 3 in the presence of a catalytic amount of Et3N. The effect of bases and solvents on the reaction efficiency and yield was briefly investigated. Treatment of 4 with an excess amount of NH4OAc in ethanol afforded 2-trifluoromethyl-1H-quinolin-5-one derivatives 5. Refluxing of 4 with TsOH in CHCl3 gave the corresponding dehydrated products 8. 相似文献
975.
Satoru Kobayashi 《Tetrahedron》2008,64(41):9705-9716
Cross-conjugated azatrienes bearing an electron-withdrawing sulfonyl or benzoyl group on the nitrogen atom underwent, on heating or in the presence of a Lewis acid (TMSOTf), an initial inverse electron-demand hetero Diels-Alder reaction with electron-rich dienophiles (vinyl ether, vinyl thioether, and allenyl ether) to produce 1:1 cycloadducts with high endo selectivity. The initial cycloadducts thus obtained underwent a second Diels-Alder reaction stereoselectively on the newly formed diene unit with electron-deficient dienophiles to give the crossed bis-cycloadducts, octahydroquinolines, with high diastereo-π-facial selectivity. The N-sulfonylazatrienes tethering an ortho-cinnamyloxyphenyl dienophile at the triene terminal underwent an initial intramolecular hetero Diels-Alder reaction of the inverse electron-demand type. The subsequent second Diels-Alder reaction of the formed mono-cycloadducts completed the diene-transmissive hetero Diels-Alder protocol to give benzopyrano[3,4-c]quinolines in a highly stereoselective manner. 相似文献
976.
Tian-Jun Wu 《Tetrahedron letters》2008,49(2):383-386
A concise enantioselective synthesis of (+)-1-epi-castanospermine (2) is described, which featured the use of chiral non-racemic tetramic acid derivative 5 as a synthetic equivalent of the challenging synthon A through a highly diastereoselective vinylogous Mukaiyama type reaction. 相似文献
977.
Adiseshu Kattuboina 《Tetrahedron letters》2008,49(10):1573-1577
Novel chiral N-phosphonyl imines 2 have been designed and synthesized using chiral N-phosphoramide 1. These N-phosphonyl imines have been successfully utilized for asymmetric aza-Darzens reaction and asymmetric aza-Henry reaction. The C2-symmetric chiral auxiliary tolerates oxidation, is not sensitive to racemization and can be recycled for large scale synthesis. 相似文献
978.
Giuseppe Bartoli 《Tetrahedron letters》2008,49(16):2555-2557
A new protocol for the Knoevenagel condensation between β-diketones and aliphatic and aromatic aldehydes promoted by Mg(ClO4)2 under mild conditions is reported. 相似文献
979.
Ariafard A Brookes NJ Stranger R Yates BF 《Chemistry (Weinheim an der Bergstrasse, Germany)》2008,14(20):6119-6124
Molecular orbital theory has been used to study a series of [(micro-N2){ML3}2] complexes as models for dinitrogen activation, with M=Mo, Ta, W, Re and L=NH2, PH2, AsH2, SbH2 and N(BH2)2. The main aims of this study have been to provide a thorough electronic analysis of the complexes and to extend previous work involving molecular orbital analyses. Molecular orbital diagrams have been used to rationalize why for L=NH2 ligand rotation is important for the singlet state but not the triplet, to confirm the effect of ligand pi donation, and to rationalize the importance of the metal d-electron configuration. The outcomes of this study will assist with a more in-depth understanding of the electronic basis for N2 activation and allow clearer predictions to be made about the structure and multiplicity of systems involved in transition-metal catalysis. 相似文献
980.
Serge Ello Laurence Pirault-Roy Attila Wootsch Zoltán Paál 《Reaction Kinetics and Catalysis Letters》2008,94(2):301-310
Platinum-germanium catalysts supported on a non-acidic Al2O3 have been prepared by adding Ge in amounts corresponding nominally to 1/8 (PtGe1/8/Al2O3); 1/2 (PtGe1/2/Al2O3); 1 (PtGe1/Al2O3) and 2 (PtGe2/Al2O3) monolayers by controlled surface reaction of Ge(n-C4H9)4 to Pt/Al2O3. These catalysts were characterized by electron microscopy (TEM), FTIR of CO adsorption and H2 chemisorption. The ring opening of ethylcyclopentane (ECP) was studied as a test reaction between 543 and 633 K. PtGe1/8/Al2O3 catalyst produced the most ring opening products (ROP) in the whole temperature range. A good agreement with statistical
values of ROP was observed at low temperature, but at higher temperature, the opening became selective, producing mostly heptane.
Bimetallic catalysts PtGe1/Al2O3 and PtGe2/Al2O3 led to a nonselective hydrogenolysis, similar to the monometallic platinum catalyst Pt/Al2O3. The catalysts PtGe1/Al2O3 and PtGe2/Al2O3 produced ROP with the lowest selectivity; instead, much aromatics and fragments were formed, in increasing amounts above
600 K. 相似文献