硼酸对赖氨酸盐酸盐在半胱氨酸自组装膜上晶体生长的影响

研究了利用半胱氨酸自组装膜对诱导L-赖氨酸盐酸盐晶体生长的影响。实验发现,赖氨酸盐酸盐优先在水溶液内而不是在自组装膜表面成核生长为晶体,这是首次发现自组装单层对赖氨酸盐酸盐的成核有抑制作用。对自组装单层上的成核机理进行了探讨,2种氨基酸正电荷间的排斥作用可能是自组装膜抑制赖氨酸盐酸盐成核的原因。在赖氨酸盐酸盐溶液中加入了等摩尔硼酸,XRD结果表明,硼酸晶体优先生长在自组装单层上。而析出后的硼酸晶体又加速促进了赖氨酸盐酸盐的结晶析出。扫描电子显微镜表征发现,加入硼酸后赖氨酸盐酸盐晶体的形貌发生了很大变化,由原来的块状变为针状。实验结果表明,加入硼酸,可以加速赖氨酸盐酸盐的晶体生长并可以调控晶体的形貌和取向。     

Advances in surface plasmon resonance-based high throughput biochips

This article reviews our recent advances in surface plasmon resonance (SPR) based biochips. It includes four issues, which are the preparation and characterization of high quality gold film, the preparation and characterization of self-assembled monolayer (SAM), dynamics of DNA adsorption on SAMs, and SPRbased microscopies. Numerous topics related to SPR, such as, the modeling of SPR by transmission matrix, effective medium theory, applications of SPR in biology, and SPR-based novel microscopies, are discussed. A novel electrochemical technique, which is extremely useful for the preparation and characterization of high quality SAMs, is also discussed.     

流动注射-电化学-表面等离子体激元共振联用技术研究二茂铁硫醇氧化还原结构变化

采用流动注射-电化学-表面等离子体激元共振联用技术研究了11-二茂铁基十一烷基-1-硫醇自组装膜在氧化还原过程中的构型变化.结果表明,二茂铁硫醇在氧化过程中,分子发生了两种结构变化:远离电极表面,烷基链与电极表面的夹角增大;分子上两个平行的戊基环绕着二茂铁-碳轴发生旋转.     

Dependence of bimodal size distribution on temperature and optical properties of InAs quantum dots grown on vicinal GaAs （100） substrates by using MOCVD

Self-assembled InAs quantum dots (QDs) are grown on vicinal GaAs (100) substrates by using metal-organic chemical vapour deposition (MOCVD). An abnormal temperature dependence of bimodal size distribution of InAs quantum dots is found. As the temperature increases, the density of the small dots grows larger while the density of the large dots turns smaller, which is contrary to the evolution of QDs on exact GaAs (100) substrates. This trend is explained by taking into account the presence of multiatomic steps on the substrates. The optical properties of InAs QDs on vicinal GaAs(100) substrates are also studied by photoluminescence (PL) . It is found that dots on a vicinal substrate have a longer emission wavelength, a narrower PL line width and a much larger PL intensity.     

辛基三乙氧基硅烷/十八烷基三氯硅烷均相混合自组装单分子膜的表征及其形成机制

使用接触角、原子力显微镜（AFM）、静电力显微镜（EFM）和傅里叶变换红外（FTIR）光谱对辛基三乙氧基硅烷（C8TES）/十八烷基三氯硅烷（OTS）均相混合自组装单分子膜（SAM）及其形成过程中样品表面的润湿性、表面形貌、表面电势和膜内分子的有序度进行了表征,对采用分步法利用C8TES分子空间位阻制备C8TES/OTS均相混合SAM的反应机制进行了研究. 结果表明,C8TES/OTS均相混合SAM表面接触角为105°,样品表面平整、光滑;对样品表面电势进行分析后发现,混合SAM表面电势分布均匀,电势频率分布为典型的正态分布;在均相混合SAM的形成过程中,样品表面电势的分布始终十分均匀,电势频率分布均为典型的正态分布;C8TES/OTS均相混合SAM是一种具有上下两层分子排列密度不同的膜结构的单分子膜,其内部结构至少在500 nm×500 nm到20 μm×20 μm尺度上是高度均匀一致的,膜内没有明显的特征结构,具有典型的均相混合SAM特征.     

巯基钴卟啉自组装膜的表征及催化性能

用自制的新型尾式巯基钴（Ⅱ）卟啉在金电极上制成自组装单分子膜,并用ＸＰＳ,ＳＥＭ和电化学的方法进行了表征。该膜对抗坏血酸具有良好的催化作用,其氧化过电位较裸金电极上降低了１４０ ｍＶ,响应电流与抗坏血酸（ＡＡ）的浓度在 ７．８ × １０－５ｍｏｌ／Ｌ～１．０×１０－２ｍｏｌ／Ｌ的范围内具有良好的线性关系,相关系数为 ０．９９８１;检测下限为 １．３ × １０－８ｍｏｌ／Ｌ（富集 １０ｍｉｎ）。     

Electrochemical Studies of Water-Soluble Palladium Nanoparticles

Aqueous-soluble monolayer-protected palladium nanoparticles were synthesized by hydrogen reduction of Pd(II) in a water solution. The particles were then further functionalized by incorporating multiple copies of mercapto derivatives of viologen into the particle protecting monolayers. The electrochemistry of the viologen moieties with the particles dissolved in solution or immobilized onto electrode surfaces was carefully studied using various electrochemical techniques. The particle molecular capacitance was evaluated by rotating-disk-electrode voltammetry and the electron-transfer rate constant of the particle-bound viologen moieties was estimated by impedance measurements.     

表面引发聚合反应研究进展

表面引发聚合反应作为一种新的聚合反应可广泛应用于固体基底的表面修饰与改性。结合分子自组装技术,几乎各种类型的聚合反应都有可能在固体基底表面进行。本文对表面引发聚合反应的研究进展进行了综述,对反应类型、实验方法、研究动向以及在合成聚合物刷、形成图案化聚合物薄膜等方面的应用与发展前景作了介绍与讨论。     

含InAs自组装量子点肖特基二极管的关联放电效应

制作了含自组织量子点的金属半导体金属双肖特基势垒器件,研究了器件的电流输运特性.在量子点充放电造成的电流迟滞回路的基础上,观察到了电压扫描过程中的电流由低态到高态的跳跃现象.这种电流跳跃来源于充电量子点的关联放电效应.根据量子点系统的哈密顿量,分析了充电量子点关联放电的原因.这种关联放电效应起源于量子点与2DEG的相互作用,当一个量子点放电时通过量子点和2DEG电流的变化会影响其他的量子点,从而促使其放电,这种过程在整个系统中放大导致所有的量子点放电 关键词： 关联效应 自组装量子点     

Electrochemical Immunoassay for Tumor Marker CA19-9 Detection Based on Self-Assembled Monolayer

A CA19-9 electrochemical immunosensor was constructed using a hybrid self-assembled membrane modified with a gold electrode and applied to detect real samples. Hybrid self-assembled membranes were selected for electrode modification and used to detect antigens. First, the pretreated working electrodes were placed in a 3-mercaptopropionic acid (MPA)/β-mercaptoethanol (ME) mixture for 24 h for self-assembly. The electrodes were then placed in an EDC/NHS mixture for 1 h. Layer modification was performed by stepwise dropwise addition of CA19-9 antibody, BSA, and antigen. Differential pulse voltammetry was used to characterize this immunosensor preparation process. The assembled electrochemical immunosensor enables linear detection in the concentration range of 0.05–500 U/mL of CA19-9, and the detection limit was calculated as 0.01 U/mL. The results of the specificity measurement test showed that the signal change of the interfering substance was much lower than the response value of the detected antigen, indicating that the sensor has good specificity and strong anti-interference ability. The repeatability test results showed that the relative standard deviations were less than 5%, showing good accuracy and precision. The CA19-9 electrochemical immunosensor was used for the actual sample detection, and the experimental results of the standard serum addition method showed that the RSD values of the test concentrations were all less than 10%. The recoveries were 102.4–115.0%, indicating that the assay has high precision, good accuracy, and high potential application value.