质子与金属布线层核反应对微纳级静态随机存储器单粒子效应的影响分析

金属布线层对微纳级静态随机存储器(static random access memory, SRAM) 质子单粒子效应敏感性的影响值得关注. 利用Geant4针对不同能量(30 MeV, 100 MeV, 200 MeV和500 MeV)的质子与微纳级SRAM器件的核反应过程开展计算, 研究了核反应次级粒子的种类、线性能量传输值(linear energy transfer, LET)及射程情况, 尤其对高LET 值的核反应次级粒子及其射程开展了详细分析. 研究表明, 金属布线层的存在和质子能量的增大为原子序数大于或等于30的重核次级粒子的产生创造了条件, 器件体硅区中原子序数大于60的重核离子来源于质子与钨材料的核反应, 核反应过程中的特殊作用机理会生成原子序数在30至50之间的次级粒子, 且质子能量的增大有助于这种作用机理的发生, 原子序数在30至50之间的次级粒子在器件体硅区的LET值最大约为37 MeV·cm²/mg, 相应射程可达到几微米, 对于阱深在微米量级的微纳级SRAM器件而言, 有引发单粒子闩锁的可能. 研究结果为空间辐射环境中宇航器件的质子单粒子效应研究提供理论支撑.     

IMEP-24 analysis of eight trace elements in toys

The International Measurement Evaluation Program (IMEP) organised the IMEP-24 interlaboratory comparison after reports in the media about high levels of lead in toys. The aim of this comparison was to verify the laboratories’ capacity to evaluate trace-element levels in a possible toy-like material according to the European Standard EN 71-3:1994. As test material, it used a former certified reference material containing levels of antimony, arsenic, barium, cadmium, chromium, mercury, lead and selenium around the limits set in the standard.Four expert laboratories confirmed the reference values (Xref) for all elements but Hg, and established a reference value for Hg. The scatter of the results reported by the participants was large, as expected, but showed a close to normal distribution around the reference values for five of the eight trace elements. The spread of results was mainly attributed to sampling and sample preparation.One major issue observed in this exercise was the lack of legislative rules about how to report the result, or, more specifically, the use of the analytical correction, which was introduced in EN 71-3:1994 to achieve consistent interpretation of results and which is to be applied when values are equal to or above the maximum limits set in the standard. Its application by the participants was very inconsistent and led to problems in their evaluation. There is clearly a need for clarification and for more formal regulations with regard to result reporting in order to minimise the risk of confusion.Participants were also asked to give their opinion with regard to the acceptability of the test material for the market. The majority correctly considered the material as non-compliant. However, almost one-third incorrectly assessed the material as compliant.     

IMEP-24 analysis of eight trace elements in toys

The International Measurement Evaluation Program (IMEP) organized the IMEP-24 interlaboratory comparison after reports in the media about high levels of lead in toys. The aim of this comparison was to verify the laboratories’ capacity to evaluate trace-element levels in a possible toy-like material according to the European Standard EN 71-3:1994. As test material, it used a former certified reference material containing levels of antimony, arsenic, barium, cadmium, chromium, mercury, lead and selenium around the limits set in the standard.Four expert laboratories confirmed the reference values (Xref) for all elements but Hg, and established a reference value for Hg. The scatter of the results reported by the participants was large, as expected, but showed a close to normal distribution around the reference values for five of the eight trace elements. The spread of results was mainly attributed to sampling and sample preparation.One major issue observed in this exercise was the lack of legislative rules about how to report the result, or, more specifically, the use of the analytical correction, which was introduced in EN 71-3:1994 to achieve consistent interpretation of results and which is to be applied when values are equal to or above the maximum limits set in the standard. Its application by the participants was very inconsistent and led to problems in their evaluation. There is clearly a need for clarification and for more formal regulations with regard to result reporting in order to minimize the risk of confusion.Participants were also asked to give their opinion with regard to the acceptability of the test material for the market. The majority correctly considered the material as non-compliant. However, almost one-third incorrectly assessed the material as compliant.     

Determining nanomaterials in food

Nanotechnology has emerged as one of the most innovative technologies and has the potential to improve food quality and safety. However, there are a few studies demonstrating that nanomaterials (NMs) are not inherently benign.This review highlights some current applications of NMs in food, food additives and food-contact materials, and reviews analytical approaches suitable to address food-safety issues related to nanotechnology.We start with a preliminary discussion on the current regulatory situation with respect to nanotechnology in relation to foods. We cover sample preparation, imaging techniques (e.g., electron microscopy, scanning electron microscopy and X-ray microscopy), separation methods (e.g., field-flow fractionation and chromatographic techniques) and detection or characterization techniques (e.g., light scattering, Raman spectroscopy and mass spectrometry). We also show the first applications of the analysis of NMs in food matrices.     

电化学免疫传感器在食品安全检测中的应用进展

介绍了3种电化学免疫传感器的组装、构建,着重评论了近十年来其在食品安全检测中的应用研究,并对其前景进行了展望(引用文献30篇)。     

规定安全间隔的CNS性能环境研究

对平行航路下规定安全间隔的CNS性能环境评估问题进行了研究.首先分析了CNS性能环境对飞机碰撞风险的影响,并结合Reich模型和概率论方法建立了CNS性能环境下飞机纵向、侧向和垂直方向上的碰撞风险模型;其次对碰撞风险模型进行分析转化得到了规定的安全间隔和安全目标水平下CNS性能环境的评估计算方法.最后对平行航路的CNS性能环境进行了评估计算,得到符合航路安全目标水平1.5×10~(-8)的CNS性能环境为RNP10、RCP400、RSP20.     

Direct determination of residual Pluronic F-68 in in-process samples from monoclonal antibody preparations by high performance liquid chromatography

A simple and sensitive high performance liquid chromatography (HPLC) method was developed to determine residual Pluronic F-68 (PF-68) in in-process samples of monoclonal antibody (MAb) preparations. The method permits the direct injection of proteinaceous samples after simple sample dilution and is able to quantitate as low as 50 mg/L of PF-68 in the presence of up to approximately 30 g/L of protein. The PF-68 molecule was separated on a restricted access reversed phase column using a step gradient and then measured by an evaporative light scattering detector (ELSD). The method was successfully applied to demonstrate PF-68 clearance in MAb purification processes. A modified colorimetric method using liquid-liquid extraction and cobalt thiocyanate to derivatize PF-68 is also described. The results obtained by both the HPLC and colorimetric methods were compared. In addition to its ease of use and simplicity, the HPLC method had better accuracy and higher throughput than the colorimetric method.     

Numerical and experimental analysis of flow and heat transfer in a fuel assembly mock-up with transverse flow above the rods

Thermal-hydraulic conditions in a partially uncovered nuclear fuel assembly mock-up are studied with particular focus on the influence of the horizontal air flow above the rod bundle. The investigations are performed at the ALADIN test facility, which models a boiling water reactor fuel assembly at a 1:1 scale both axially and radially. In the scenario studied, the main heat transfer mechanisms – conduction, convection and radiation – are strongly coupled and all are of similar importance. A combination of measurements and CFD simulations serves to analyze the heat transfer processes in detail. Contrary to previous studies in this field, all heat transfer mechanisms were considered in the simulation with sophisticated models. The numerical results show a good agreement with the measurements, given the inevitable differences between the approaches. Although the successive evaporation of cooling water in a fuel assembly is a transient, multiphase process, the steady, single-phase simulation yields acceptable results. While single effects are overestimated in the simulation, the important dependencies are predicted similarly. A general result is that the maximum cladding temperature rises with decreasing water level. Further results indicate an impact of the horizontal air flow on the residual heat removal for moderate rod powers. Higher horizontal velocities above the fuel assembly lead to slightly higher temperatures inside. A characteristic flow field forms in the test facility that prevails for all studied water levels and horizontal velocities. However, it has only a minor effect on the temperature distribution in the central rod bundle. By combining experiments and numerical simulations, the study provides important information about the decisive parameters for the heat exchange in a spent fuel pool in case of an accident with loss of cooling. The exposed length of the fuel rods is of much more importance than the magnitude of the horizontal velocity above the fuel assembly.     

平台参与下网络食品安全政府监管策略研究

针对“互联网+食品”新兴业态产生的更为严峻的食品安全问题,本文研究政府对网络食品安全实施直接监管下的最优监管策略,以及在网络平台参与监管时政府的最优间接监管策略,并考虑了网络平台与食品企业合谋对监管效率的影响。结果表明,在食品安全问题被发现的概率越大或食品安全问题发生对政府影响较大时,选择直接监管策略会更优;但监管成本的增加会降低政府直接监管的动因,促使政府选择间接监管策略;比较两种策略可知,间接监管模式更能抑制平台与企业的合谋行为。此外,研究还表明在直接监管策略下,由于提高食品企业的惩罚力度会降低政府的监管强度,因此加大惩罚并不总能提高政府的效益;而在间接监管策略下,加大对网络平台的惩罚会使网络平台加大监管力度,从而提高政府的效益。     

The Applicability of Essential Oils in Different Stages of Production of Animal-Based Foods

Essential oils (EOs) have been used for centuries, and interest in these compounds has been revived in recent years. Due to their unique chemical composition as well as antimicrobial, immunostimulatory, anti-inflammatory and antioxidant properties, EOs are used in pharmacology, cosmetology and, increasingly, in animal breeding and rearing, and processing of animal raw materials. Essential oils have become a natural alternative to preservatives, taste enhancers and, most importantly, antibiotics, because the European Union banned the use of antibiotics in metaphylaxis in animal husbandry in 2006. In the animal production chain, EOs are used mainly as feed additives to improve feed palatability and increase feed intake, improve animal resistance and health status, and to prevent and treat diseases. Recent research indicates that EOs can also be applied to sanitize poultry houses, and they can be used as biopesticides in organic farming. Essential oils effectively preserve meat and milk and, consequently, improve the safety, hygiene and quality of animal-based foods. Novel technologies such as encapsulation may increase the bioavailability of EOs and their application in the production of food and feed additives.