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91.
Alyssa B. Sanders Jacob T. Zangaro Nakoa K. Webber Ryan P. Calhoun Elizabeth A. Richards Samuel L. Ricci Hannah M. Work Daniel D. Yang Kaitlyn R. Casey Joseph C. Iovine Gabriela Baker Taylor V. Douglas Sierra B. Dutko Thomas J. Fasano Sarah A. Lofland Ashley A. Rajan Mihaela A. Vasile Benjamin R. Carone Nathaniel V. Nucci 《Molecules (Basel, Switzerland)》2022,27(5)
Despite considerable advances in recent years, challenges in delivery and storage of biological drugs persist and may delay or prohibit their clinical application. Though nanoparticle-based approaches for small molecule drug encapsulation are mature, encapsulation of proteins remains problematic due to destabilization of the protein. Reverse micelles composed of decylmonoacyl glycerol (10MAG) and lauryldimethylamino-N-oxide (LDAO) in low-viscosity alkanes have been shown to preserve the structure and stability of a wide range of biological macromolecules. Here, we present a first step on developing this system as a future platform for storage and delivery of biological drugs by replacing the non-biocompatible alkane solvent with solvents currently used in small molecule delivery systems. Using a novel screening approach, we performed a comprehensive evaluation of the 10MAG/LDAO system using two preparation methods across seven biocompatible solvents with analysis of toxicity and encapsulation efficiency for each solvent. By using an inexpensive hydrophilic small molecule to test a wide range of conditions, we identify optimal solvent properties for further development. We validate the predictions from this screen with preliminary protein encapsulation tests. The insight provided lays the foundation for further development of this system toward long-term room-temperature storage of biologics or toward water-in-oil-in-water biologic delivery systems. 相似文献
92.
Partial ionization cross section experiments have been carried out recently at the University of Innsbruck for three types of hydrocarbons, i.e. acetylene, ethylene and propene. Cross section data fits are generated and compared to the compilation of earlier experimental data summarized in the online database HYDKIN [www.hydkin.de]. New data fits are brought into a suitable form to be incorporated into the database. In order to illuminate underlying dissociation mechanisms the energy dependence of branching ratios above energies of 20 –30 eV is reviewed in light of the present results (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
93.
基于面向对象技术的多媒体CAI素材库系统 总被引:1,自引:0,他引:1
建立实用、高效的多媒体CAI素材库是高效率、高质量开发CAI软件的基础和关键.本文从数据模型、面向对象分析和存储模式三方面入手,提出一种支撑CAI制作工具的素材库体系结构,并讨论该体系结构的特性和进一步研究的问题. 相似文献
94.
Regularity Results for the
Generalized Beltrami System 总被引:1,自引:0,他引:1
Abstract
For the generalized Beltrami system with two
characteristic matrices, we deal with the regularity of its very
weak solutions in the Sobolev class
(1 <
r <
n). By changing the
generalized Beltrami system into a class of a divergent elliptic
system with nonhomogeneous items, we obtain that each of its
very weak solutions is essentially a classical weak solution of
a usual Sobolev class. Furthermore, we also establish a higher
regularity of its weak solution if the regularity hypotheses of
two characteristic matrices are improved.
Supported by the National Natural Science Foundation
of China (49805005) and by the research foundation of Northern
Jiaotong University (2002SM061) 相似文献
95.
Non-destructive testing of tubes using a time reverse numerical simulation (TRNS) method 总被引:4,自引:0,他引:4
A method for the detection of defects in cylindrical structures and the determination of their positions and orientations is presented in this paper. The scattered field, which is generated by the interaction of excited guided waves with a defect, is evaluated with an approach named time reverse numerical simulation method (TRNS). Since the excited waves and the scattered field propagate along the sample, the time-consuming scanning of the whole tube can be eliminated. The scattered displacement field is measured in three dimensions over time with a laser vibrometer at different locations distributed equally around the circumference at a fixed axial coordinate far away from the defect. Instead of analyzing the complicated time signals directly, they are played back in time. If the recorded displacement histories of the scattered field are reversed in time and played back in an identical structure, the waves travel back the same path and interfere to a maximum at their origin. The result is an amplitude increase at the position of the defect where the scattered field was generated. Instead of playing back the recorded time signals in an experiment, this step is replaced by a numerical simulation. Only this enables the visualization and detection of the amplitude increase. As long as the simulation is of high accuracy, the position of the maximum interference corresponds exactly to the location of the defect in the experiment, although no defect is implemented in the simulation. 相似文献
96.
Dobson G Murrell J Despeyroux D Wind F Tabet JC 《Journal of mass spectrometry : JMS》2004,39(11):1295-1304
Electrospray ionization mass spectra obtained from different scan directions are observed to be dependent on the axial modulation potential amplitudes used for resonant ejection and on the positive deviation caused by higher even-multipole fields present in most commercial ion traps. The axial modulation voltage influences the dissociation of ions during resonant ejection and the observed mass shifts. The higher even-multipole fields in commercial ion traps are known to influence resonant ejection from the ion trap and can cause a loss in mass resolution for peaks in reverse scan mass spectra compared with that obtained by the forward scan. However, along with the dissociation of ions during resonant ejection causing a loss in resolution, the possibility of resolving an isotopic distribution is also shown to be influenced by the mass shifts caused by the space charge. These mass shifts differ depending on the scan direction employed. A significant loss in resolution can also result from resonant ejection using non-optimal axial modulation voltages. We also present results showing the ejection of ions at betaz = 1/2 using the reverse scan mode without the axial modulation voltage. Ion ejection at betaz = 1/2 is uncommon in commercial (stretched ion traps) with the conventional analytical scan without the use of a frequency of the axial modulation voltage corresponding to this non-linear resonance. 相似文献
97.
Evgenia G. Matveeva Marina I. Nelen Oleg I. Lobanov Alexander P. Savitsky 《Journal of fluorescence》2003,13(1):79-88
The antigen-antibody interaction between coproporphyrin I and anti-coproporphyrin antibodies was studied by a fluorescence method in water and a reverse micellar system: n-octane/Aerosol OT. Coproporphyrin fluorescence was quenched, and coproporphyrin emission maximum was shifted to the long-wavelength region after binding to the antibodies or Fab-fragments. The mechanism of this quenching is static, most probably, by a tryptophan residue (or maybe lysine or methionine). Apparent dynamic quenching, in this case, arises from protein backbone motion. A special kind of antibody Fab-Fab dimerization was proposed. 相似文献
98.
Baha-Eldin Khaledi Subhash Kochar 《Annals of the Institute of Statistical Mathematics》2001,53(3):620-630
Consider a multivariate mixture model where the random variables X
1, ..., X
n
given (1, ...,
n
), are conditionally independent. Conditions are obtained under which different kinds of positive dependence hold among X
i
's. The results obtained are applied to a variety of problems including the concomitants of order statistics and of record values; and to frailty models. 相似文献
99.
100.
Yun Chen Qing-sheng Wu Rong-hui Yin Ya-ping Ding 《Journal of nanoparticle research》2007,9(2):283-287
Uniform Pb(OH)Cl nanotubes were synthesized for the first time through a reverse micelles system. The system was consisting
of C12E9 as a surfactant, n-pentanol as a cosurfactant, hexamethylene as the continuous oil phase and lead acetate or sodium chloride
solution as the dispersed aqueous phase. The obtained Pb(OH)Cl nanotubes have an average outer diameter of 60 nm, inner diameter
of about 40 nm, and an length up to 3 μm as TEM picture showed. And the range of the nanotube diameter is from 50 nm to 70 nm.
XRD result indicated that Pb(OH)Cl crystallized in an orthorhombic phase. Photoluminescent (PL) spectrum showed that the product
emit in near ultraviolet region and visible region at 335 nm and 439 nm respectively. The experimental results show that reaction
temperature have effect on the shape of Pb(OH)Cl nanotubes. A possible formation mechanism was also discussed. 相似文献