全文获取类型
收费全文 | 15643篇 |
免费 | 1334篇 |
国内免费 | 643篇 |
专业分类
化学 | 15328篇 |
晶体学 | 324篇 |
力学 | 22篇 |
综合类 | 15篇 |
数学 | 64篇 |
物理学 | 1867篇 |
出版年
2024年 | 8篇 |
2023年 | 143篇 |
2022年 | 416篇 |
2021年 | 477篇 |
2020年 | 478篇 |
2019年 | 358篇 |
2018年 | 299篇 |
2017年 | 273篇 |
2016年 | 550篇 |
2015年 | 551篇 |
2014年 | 589篇 |
2013年 | 1156篇 |
2012年 | 715篇 |
2011年 | 675篇 |
2010年 | 753篇 |
2009年 | 761篇 |
2008年 | 796篇 |
2007年 | 814篇 |
2006年 | 782篇 |
2005年 | 718篇 |
2004年 | 759篇 |
2003年 | 692篇 |
2002年 | 1421篇 |
2001年 | 393篇 |
2000年 | 325篇 |
1999年 | 323篇 |
1998年 | 298篇 |
1997年 | 214篇 |
1996年 | 419篇 |
1995年 | 396篇 |
1994年 | 143篇 |
1993年 | 117篇 |
1992年 | 132篇 |
1991年 | 82篇 |
1990年 | 56篇 |
1989年 | 72篇 |
1988年 | 69篇 |
1987年 | 41篇 |
1986年 | 41篇 |
1985年 | 56篇 |
1984年 | 43篇 |
1983年 | 25篇 |
1982年 | 21篇 |
1981年 | 19篇 |
1980年 | 14篇 |
1979年 | 10篇 |
1978年 | 13篇 |
1975年 | 7篇 |
1971年 | 48篇 |
1970年 | 25篇 |
排序方式: 共有10000条查询结果,搜索用时 687 毫秒
971.
采用密度泛函理论(DFT)计算研究了苯酚、邻甲酚、愈创木酚在不同结构Ru-Fe(211)表面上吸附活化性能和加氢脱氧反应路径.结果表明,Ru掺杂能促进H2分子在Fe(211)表面上解离,提高加氢脱氧反应速率.酚类在1Ru_(ads)-Fe(211)表面上吸附比在1Ru_(sub)-Fe(211)表面上更稳定,苯酚和邻甲酚脱羟基步骤能垒分别降低0.13和0.28 eV,有利于生成芳烃.愈创木酚在1Ru_(sub)-Fe(211)表面上加氢脱氧优势路径是先脱甲氧基生成苯酚,苯酚再加氢脱氧生成产物苯(速控步骤能垒1.16 eV);而在1Ru_(ads)-Fe(211)表面上愈创木酚先脱羟基再脱甲基生成苯酚的路径更具有动力学优势(速控步骤能垒1.21 eV).计算结果表明Ru掺杂方式影响Fe催化剂对酚反应分子的吸附稳定性以及加氢脱氧反应路径和性能.与1Ru掺杂Fe(211)催化剂相比,增加Ru原子数形成4Ru_(ads)-Fe(211),能够进一步提高酚类反应物的吸附强度,但导致加氢脱氧反应能垒升高.因此,在Fe催化剂上以表面吸附的形式掺杂少量贵金属Ru更利于酚类加氢脱氧生成芳烃. 相似文献
972.
《Journal of Saudi Chemical Society》2022,26(6):101571
Mitochondrial dysfunction has been associated with diverse pathological conditions globally. Specifically, in adipose tissues, mitochondrial dysfunction is the primary cause of obesity and obesity-related illnesses. An existing drugs such as atorvastatin and other lipid-lowering drugs demonstrated adverse effects and initiated other diseases. Thus, we need to explore new methods to prevent and treat obesity. In this study, we used the cell screening method to identify several natural compounds that increase adipocyte UCP1 gene expression. The identified drug Curcumin was evaluated in cell models and the In-silico model. We found curcumin is an active compound of turmeric belonging to Zingiberaceae (ginger family), which activates the Nrf2 mechanism. Curcumin potentially endorses the expression of UCP1 in the brown adipocyte in vitro cellular model. Curcumin plays an important role that modulating mitochondrial function and improving mitochondrial DNA quantification, ATP production, and cell viability. We have established an efficient in vitro cell experiment system to study the metabolic regulation of UCP1. The in-silico model revealed curcumin-UCP1 interaction. Curcumin, via enhancing mitochondrial activity, could be a helpful therapeutic molecule against metabolic disorders or obesity-related diseases. Curcumin will be the subject of more research in both human and murine models, which will provide novel therapeutic pathways for the treatment of metabolic illnesses by modulating the control of mitochondrial function. 相似文献
973.
Dr. Nataliia S. Kariaka Dr. Victor A. Trush Dr. Viktoriya V. Dyakonenko Dr. Svitlana V. Shishkina Dr. Sergii S. Smola Dr. Nataliia V. Rusakova Dr. Tetiana Y. Sliva Dr. Paula Gawryszewska Dr. Albano N. Carneiro Neto Prof. Dr. Oscar L. Malta Prof. Dr. Vladimir M. Amirkhanov 《Chemphyschem》2022,23(14):e202200129
New lanthanide dimethyl-N-benzoylamidophosphate (HL) based tetrakis-complexes NEt4[LnL4] (Ln3+=La, Nd, Sm, Eu, Gd, Tb, Dy) are reported. The complexes are characterized by means of NMR, IR, absorption, and luminescent spectroscopy as well as by elemental, X-Ray, and thermal gravimetric analyses. The phenyl groups of the four ligands of the complex anion are directed towards one side, while the methoxy groups are directed in the opposite side, which makes the complexes under consideration structurally similar to calixarenes. The effect of changing the alkali metal counterion to the organic cation NEt4+ on the structure and properties of the tetrakis-complex [LnL4]- is analyzed. The complexes exhibit bright characteristic for respective lanthanides luminescence. Rather high intensity of the band of 5D0→7F4 transition, observed in the luminescence spectrum of NEt4[EuL4], is discussed based on theoretical calculations. 相似文献
974.
Nitrogen-containing compounds, as an important class of chemicals, have been used widely in pharmaceuticals, materials synthesis. Transition metal-catalyzed reductive amination of an aldehyde or a ketone with ammonia or an amine has been proved to be an efficient and practical method for the preparation of nitrogen-containing compounds in academia and industry for a century. Given the above, several effective methods using transition metals have been developed in recent years. Noble transition metals like Pd, Pt, and Au-based catalysts have been predominately used in reductive amination. Because of their high prices, strict official regulations of residues in pharmaceuticals, and deleterious effects on the biological system, their industrial applications are severely hampered. With the increasing sustainable and environmental problems, the Earth-abundant transition metals including Ti, Fe, Co, Ni, and Zr have also been investigated for the reductive amination reaction and showed great potential to the advancement of sustainable and cost-effective reductive amination processes. This critical review will mainly summarize the work using Earth-abundant metals. The effects of different transition metals used in catalytic reduction amination were discussed and compared, and some suggestions were given. The last section highlights the catalytic activities of bi- and tri-metallic catalysts. Indeed, this latter family is very promising and simultaneously benefits from increased stability, and selectivity, compared to monometallic NPs, due to synergistic substrate activation. Few comprehensive reviews focusing on Earth-abundant transition metals catalyst has been published since 1948, although several authors reported some summaries dealing with one or the other part of this aspect. It is hoped that this critical review will inspire researchers to develop new efficient and selective earth-abundant metal catalysts for highly, environmentally sustainable reductive amination methods, as well as improve the pharmaceutical industry and related chemical synthesis company traditional method with the utilization of the green method widely. 相似文献
975.
The application of ionic liquids for the dissolution of metal oxides is a promising field for the development of more energy- and resource-efficient metallurgical processes. Using such solutions for the production of valuable chemicals or electrochemical metal deposition requires a detailed understanding of the chemical system and the factors influencing it. In the present work, several compounds are reported that crystallize after the dissolution of copper(II) oxide in the ionic liquid [Hbet][NTf2]. Dependent on the initial amount of chloride, the reaction temperature and the purity of the reagent, copper crystallizes in complexes with varying coordination geometries and ligands. Subsequently, the influence of these different complex species on electrochemical properties is shown. For the first time, copper is deposited from the ionic liquid [Hbet][NTf2], giving promising opportunities for more resource-efficient copper plating. The copper coatings were analyzed by SEM and EDX measurements. Furthermore, a mechanism for the decomposition of [Hbet][NTf2] in the presence of chloride is suggested and supported by experimental evidence. 相似文献
976.
In order to extract antioxidant phenolic compounds from spent grain (SG) two extraction methods were studied: the ultrasound-assisted method (US) and the Ultra-Turrax method (high stirring rate) (UT). Liquid to solid ratios, solvent concentration, time, and temperature/stirring rate were optimized. Spent grain extracts were analyzed for their total phenol content (TPC) (0.62 to 1.76 mg GAE/g SG DW for Ultra-Turrax pretreatment, and 0.57 to 2.11 mg GAE/g SG DW for ultrasound-assisted pretreatment), total flavonoid content (TFC) (0.6 to 1.67 mg QE/g SG DW for UT, and 0.5 to 1.63 mg QE/g SG DW for US), and antioxidant activity was measured using 2,2-diphenyl-2-picrylhydrazyl (DPPH) free radical (25.88% to 79.58% for UT, and 27.49% to 78.30% for UT). TPC was greater at a high stirring rate and high exposure time up to a certain extent for the Ultra-Turrax method, and at a high temperature for the ultrasound-assisted method. P-coumaric acid (20.4 ± 1.72 mg/100 SG DW for UT, and 14.0 ± 1.14 mg/100 SG DW for US) accounted for the majority of the phenolic found compounds, followed by rosmarinic (6.5 ± 0.96 mg/100 SG DW for UT, and 4.0 ± 0.76 mg/100 SG DW for US), chlorogenic (5.4 ± 1.1 mg/100 SG DW for UT, and non-detectable for US), and vanillic acids (3.1 ± 0.8 mg/100 SG DW for UT, and 10.0 ± 1.03 mg/100 SG DW for US) were found in lower quantities. Protocatechuic (0.7 ± 0.05 mg/100 SG DW for UT, and non-detectable for US), 4-hydroxy benzoic (1.1 ± 0.06 mg/100 SG DW for UT, and non-detectable for US), and caffeic acids (0.7 ± 0.03 mg/100 SG DW for UT, and non-detectable for US) were present in very small amounts. Ultrasound-assisted and Ultra-Turrax pretreatments were demonstrated to be efficient methods to recover these value-added compounds. 相似文献
977.
The benefits of natural honeybee products (e.g., honey, royal jelly, beeswax, propolis, beevenom and pollen) to the immune system are remarkable, and many of them are involved in the induction of antibody production, maturation of immune cells and stimulation of the immune system. The type of plants in the geographical area, climatic conditions and production method have a significantly influence on the nutritional quality of honey. However, this variability can influence consumer liking by the sensory attributes of the product. The aim of this work was to compare the most popular honeys from Poland in terms of nutritional value, organoleptic properties and antioxidant activity. In the study, five varieties of honey (honeydew, forest, buckwheat, linden and dandelion) from conventional and organic production methods were tested. The nutritional characteristics of honey samples included acidity, content of water, sugars, vitamin C, HMF and phenolics (total and flavonoids), while honey color, taste, aroma and consistency were investigated in the organoleptic characteristics. The antioxidant activity was determined in water- and ethanol-soluble honey extracts using DPPH and ORAC tests. The results showed that organoleptic and nutritional characteristics of popular Polish honeys differ significantly in relation to plant source and production method. The significant effect of honey variety on the content of HMF, saccharose and phenolics, as well as acidity and antioxidant capacity were noted. The impact of variety and variety × production method interaction was significant in the case of the content of vitamin C, glucose and fructose. A visible difference of buckwheat and forest honeys from other samples was observed. The highest content of total phenolics with antioxidant activity based on the SET mechanism was found in buckwheat honeys, while forest honeys were richer in flavonoids. 相似文献
978.
Mozaniel Santana de Oliveira Jorddy Neves Cruz Oberdan Oliveira Ferreira Daniel Santiago Pereira Natanael Santiago Pereira Marcos Enê Chaves Oliveira Giorgio Cristino Venturieri Giselle Maria Skelding Pinheiro Guilhon Antnio Pedro da Silva Souza Filho Eloisa Helena de Aguiar Andrade 《Molecules (Basel, Switzerland)》2021,26(11)
Propolis is a balsamic product obtained from vegetable resins by exotic Africanized bees Apis mellifera L., transported and processed by them, originating from the activity that explores and maintains these individuals. Because of its vegetable and natural origins, propolis is a complex mixture of different compound classes; among them are the volatile compounds present in the aroma. In this sense, in the present study we evaluated the volatile fraction of propolis present in the aroma obtained by distillation and simultaneous extraction, and its chemical composition was determined using coupled gas chromatography, mass spectrometry, and flame ionization detection. The majority of compounds were sesquiterpene and hydrocarbons, comprising 8.2–22.19% α-copaene and 6.2–21.7% β-caryophyllene, with additional compounds identified in greater concentrations. Multivariate analysis showed that samples collected from one region may have different chemical compositions, which may be related to the location of the resin’s production. This may be related to other bee products. 相似文献
979.
Jana ic
labur Marko Brajer Sandra Voa Ante Gali Sanja Radman Suzana Rimac-Brn
i Qiang Xia Zhenzhou Zhu Nabil Grimi Francisco J. Barba Nataa Hulak 《Molecules (Basel, Switzerland)》2021,26(7)
Spices are a popular food of plant origin, rich in various phytochemicals and recognized for their numerous properties. The aim of the study was to evaluate the antioxidant and antimicrobial activity, as well as the content of specialized metabolites, of aqueous extracts of three spice species––garlic (Allium sativum L.), ginger (Zingiber officinalle L.) and turmeric (Curcuma longa L.)––prepared by green extraction methods. Ultrasound treatment increased the chromaticity parameter b value of turmeric and ginger extracts, thus indicating a higher yellow color predominantly due to curcuminoids characteristic of these species. Ultrasound-assisted extraction significantly increased the content of total soluble solids, phenolic compounds, total carotenoids and vitamin C. The temperature of the system was also an important factor, with the highest (70 °C) conditions in ultrasound-assisted extraction having a positive effect on thermolabile compounds (vitamin C, phenolics, total carotenoids). For example, turmeric extract treated with ultrasound at 70 °C had up to a 67% higher vitamin C content and a 69.4% higher total carotenoid content compared to samples treated conventionally at the same temperature, while ginger extracts had up to 40% higher total phenols. All different concentrations of spice extracts were not sufficient for complete inhibition of pathogenic bacterial strains of Salmonella, L. monocytogenes and S. aureus; however, only garlic extracts had an effect on slowing down the growth and number of L. monocytogenes colonies. Spice extracts obtained by ultrasonic treatment contained a significantly higher level of bioactive compounds and antioxidant capacity, suggesting that the extracts obtained have significant nutritional potential and thus a significant possibility for phytotherapeutic uses. 相似文献
980.