高纯氧化钪中稀土杂质的电感耦合等离子体质谱法测定

研究了用电感耦合等离子体质谱法测定高纯氧化钪中１５个稀土杂质的方法。考察了基体效应及内标的作用，采用Ｉ或Ｃｓ为内标可很好补偿基体ＳＣ的影响。方法检测限为０．０１３－０．０８５ｎｇ／ｍｌ，加料回收率为９１．２％－１０５．７％，相对标准偏 １．４％－８．１％。     

安培检测芯片毛细管电泳及其初步应用

An end-channel amperometric detector with a guide tube for working electrode was designed and integrated on a home-made glass microchip. The guide tube was directly patterned and fabricated at the end of the detection reservoir, which made the fixation and alignment of working electrode relatively easy. The fabrication was carried out in a two-step etching process. A 30 μm carbon fiber microdisk electrode and Pt cathode were also integrated onto the amperometric detector. The baseline separation of dopamine (DA), catechol (CA) and epinephrine (EP) was achieved within 80 s. Relative standard deviations of not more than 5.2% were obtained for both peak currents and migration times of DA and CA (n=5). Using standard adding method, DA in tLrine and plasma samples was detected. The recoveries were in the range of 83%—103%.     

河口水体中痕量稀土元素的共沉淀预富集-电感耦合等离子体质谱法测定研究

建立了氢氧化铟共沉淀预富集 -电感耦合等离子体质谱法测定河口水体中痕量稀土元素的方法。实验结果表明 ,在80mg·L -1的In3 +和pH9.5的实验条件下 ,在1.0L水样中添加5.0～200.0ng的混合稀土标准溶液 ,均能定量回收 ,回收率在82.2 %～106.9 %之间。方法的分析流程空白为0.04(Tb)～10.17(La)ng·L -1,检出限在0.17(Yb)～1.46(La)ng·L-1之间 ,精密度 (RSD ,n=3)小于11.7 % ,可满足河口淡水和海水样品中的痕量稀土元素定量分析的要求     

高效液相色谱-质谱联用技术测定人血浆中双氢青蒿素的含量

建立了测定人血浆中的双氢青蒿素的液相色谱 -质谱联用法。色谱条件 :AlltimaC18 柱 (2.1×150mm ,5μm ,流动相 :甲醇 -水 (体积比85∶15) ;流速 :0.2mL/min ;柱温 :25℃ ;进样量 :20μL。质谱条件 :电喷雾离子源 (ESI) ;用于定量分析的离子分别为m/z307(双氢青蒿素) ,m/z275(蒿甲醚 )。样品用液 -液萃取方法处理。双氢青蒿素的线性范围为5～200μg·L -1,定量下限为5μg·L -1,日内、日间精密度 (RSD)均小于10 % ,萃取回收率在71.5 %～83.2 %之间 (n=5) ,分析方法回收率在98.4 %～101.9 %之间 (n=5)。本法操作简便、准确、灵敏度高 ,适用于双氢青蒿素的药代动力学研究     

电感耦合等离子体质谱法测定血液和精液中的硼

采用HNO3-H2O2和氨水-甘露醇两种方法处理样品,电感耦合等离子体质谱法（ICP-MS）测定血液和精液中的硼。Be作内标补偿基体效应,并用标准加入法验证了方法的可靠性,标准加入法与外标法测定结果相吻合。在测定B的同时,还可进行Cr、Cu、Cd、Ba、Sr、Mn、Co、Tl、Li、Pb、Zn、Sc、Ti、V、As等多元素测定。两种样品处理方法的测定值呈显著正相关（r=0.99919）。方法检出限为0．11ng／mL（氨水-甘露醇法）,0.06ng／mL（HNO3-H2O2）。已用于测定某硼矿区血液和精液样品中的硼。     

Hydrophilic Treatment of the Dyed Nylon-6 Fabric using High-density and Extensible Antenna-coupling Microwave Plasma System

High density and well surface-distributed oxygen microwave plasma with an extensible antenna-coupling design was utilized to modify a densely weaved and large-surface-area Nylon-6 fabric within a short treatment time. Plasma pretreatment and subsequent acrylic acid (AAc) or 2-hydroxyethyl methacrylate (HEMA) grafting process were studied and optimized at the stage after dyed and finished procedure. The monomer-grafted dyed Nylon-6 fabrics evolved lasting hydrophilic properties and thereafter created or improved surface properties such as water diffusion, drainage, moisture regain and water absorbency, in different degrees. The pHEMA-grafted sample exhibited minor effect in color perception, which was also much hydrophilic than the pAAc-grafted one. Based upon surface analyses and wetting assessment, the penetration of HEMA monomer into the plasma-treated fabric matrix contributed to the facilitation of wetting properties. This work accordingly ensures such plasma-induced system to incorporate with the pattern of hydrophilic properties on the analogous textiles without interrupting their finishing process.     

Formation of Iron Macro-Spheres in Plasma

In this paper the formation mechanism of iron macro-spheres in a plasma medium is dealt with, including the conditions under which such spheres are formed. The geometry of the spheres referred to above depends on the main technological parameters involved in the production of pores. Conditions under which pores occur within macro-spheres are also established. The radii of these pores are sensitive to the velocity distribution within the plasma jet section     

Development of superparamagnetic high-magnetization C18-functionalized magnetic silica nanoparticles as sorbents for enrichment and determination of methylprednisolone in rat plasma by high performance liquid chromatography

In this study, a novel extraction and enrichment technique based on superparamagnetic high-magnetization C₁₈-functionalized magnetic silica nanoparticles (C₁₈-MNPs) as sorbents was successfully developed for the determination of methylprednisolone (MP) in rat plasma by high performance liquid chromatography (HPLC). The synthesized silica-coated magnetite modified with chlorodimethyl-n-octadecylsilane was about 320 nm in diameter with strong magnetism and high surface area. It provided an efficient way for extraction and concentration of MP in the samples through hydrophobic interaction by the interior C₁₈ groups. Moreover, MP adsorbed with C₁₈-MNPs could be simply and rapidly isolated through placing a strong magnet on the bottom of container, and then easily eluted from C₁₈-MNPs by n-hexane solution. Extraction conditions such as amounts of C₁₈-MNPs added, adsorption time and desorption solvent, were investigated. Method validations including linear range, detection limit, precision, and recovery were also studied. The results showed that the proposed method based on C₁₈-MNPs was a simple, accurate and high efficient approach for the analysis of MP in the complex plasma samples.     

Dodging matrix effects in liquid chromatography tandem mass spectrometric assays—compilation of key learnings and perspectives

Triple quad liquid chromatography mass spectrometric assays (LC/MS/MS) have revolutionized the analysis of drug(s)/metabolite(s) with exceptional speed, sensitivity and selectivity features. From inception to date, several new and innovative features have been regularly proposed by researchers to further enhance the value in the applicability of this analytical tool. However, owing to such compressed run times and scanty sample preparation procedures, LC/MS/MS assays that are not fully optimized generally have issues of matrix effects, where ionization potential is either suppressed or enhanced due to the presence of other materials (endogenous/exogenous) in the matrix. By definition, even co‐medications, isomeric or isobaric impurities, and drug excipients used in dosing solutions could also potentially contribute to matrix effects. This article captures some of the interesting work carried out by researchers to understand and handle matrix effects. Additionally, it provides perspectives to effectively deal with matrix effects. Copyright © 2008 John Wiley & Sons, Ltd.     

Unstable plasma characteristics in mirror field electron cyclotron resonance microwave ion source

Electron cyclotron plasma reactor are prone to instabilities in specific input power [3–7] region (150–450 watts). In this region power absorption by gas molecules in the cavity is very poor and enhanced input power gets reflected substantially without increasing ion density. There are abrupt changes in plasma characteristics when input power was decreased from maximum to minimum, it was observed that reflected power changed from <2% to ∼50%. Minimum two jumps in reflected power were noticed in this specific power region and these appear to be highly sensitive to three stub tuner position in the waveguide for this particular input power zone. Unstable plasma region of this source is found to be dependent upon the magnetic field strength. Some changes in reflected power are also noticed with pressure, flow and bias and they are random in nature.