The efficient approach for the synthesis of [2,3,6-tri-O-(2-bromo-2-methylpropionyl]-β-cyclodextrin) (21Br-β-CD) is described. The reaction between 2-bromoisobutyric bromide and β-cyclodextrin was performed directly in 1-methyl-2-pyrrolidione solvent, leading to much less complicated procedures and higher yield (up to 89.5%) compared with those reported previously (17% yield). The product is an extremely useful initiator in synthesizing star polymers with well-defined structures using atom transfer radical polymerization for biomedical applications. 相似文献
The B‐ala/AIBN PBZ system has a high extent of ring‐opening of oxazine because phenol‐containing oligomers are formed at the early stage of the curing process. As a result, the B‐ala/AIBN PBZ system possesses a relatively stronger intramolecular hydrogen bonding and lower surface energy than the pure B‐ala system at low temperature curing. In this context, poly(4‐vinyl pyridine), poly(4‐vinyl phenol) thin films and polycarbonate substrates, which lack liquid resistance, possess low surface free energy after modification with B‐ala/AIBN = 5/1 PBZ.
The intramolecular chain oxidation of artemisinin was analyzed using the parabolic model. The competition of the mono- and
bimolecular peroxy radicals formed from artemisinin was considered. Artemisinin is predominantly oxidized via the intramolecular chain mechanism to form polyatomic hydroperoxides. This results in the situation when, under aerobic conditions,
artemisinin is transformed from the monofunctional into polyfunctional initiator with several hydroperoxide groups. The enthalpy
was calculated, and the activation energies and rate constants of the intramolecular reactions of the artemisinin peroxy radicals,
as well as those of their bimolecular reactions with C-H, S-H, and O-H bonds of biological substrates and their analogs, were
calculated in the framework of the parabolic model. A new kinetic scheme for artemisinin oxidation was proposed.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 267–275, February, 2008. 相似文献