蔗糖酯示波极谱分析法的研究

蔗糖酯分子在碱性条件下，加热水解为蔗糖和硬酯酸，在ｐＨ＞１０的ＮＨ＿３·Ｎ＿２Ｏ－（ＮＨ＿３）＿３Ｃ＿６Ｈ＿５Ｏ＿７体系中，于示波极谱仪上，峰电位─０．９１Ｖ处出现一灵敏度高和稳定性好的极谱图，其浓度从０．０２～０．２８ｍｇ／ｍＬ与峰电流呈线性关系，最低检出限为０．００４ｍｇ／ｍＬ，相对标准偏差为１．３％。     

二元酸茄呢醇乳糖和麦芽糖酯合成及生是活性测试研究

七个二元酸茄呢基单酯分别与溴代乙酰乳糖和溴代乙酰麦芽糖在四丁基溴化铵 催化下反应生成对应的糖酯，制得的十四个化合物均为新化合物，其结构经过了元 素分析、IR，~1H NMR和MS确证。并对六个化合物做了KB（人口腔上皮癌细胞）、 Bel-7402（人肝癌细胞）、HCT-8（人结肠癌细胞）三种癌细胞初步生理活性测试。     

Zur Synthese von fungizid wirksamen Isocamphanderivaten: Synthesen in der Isocamphanreihe, 34. Mitt.

Summary Some esters of isocamphenilanic acid (4) have been prepared and tested for their fungicidal and insecticidal activity. Esters of various acids with isocamphanyl ethylalcohol (5) have also been synthesized and included in the fungicidal/acaricidal/insecticidal screening programme. All esters bear a geminal dimethyl group at C-3 of the bicyclus which is important because of its shielding effect.

     

有机锗氨基酸酯类系列化合物的快原子轰击质谱规律

为增强有机锗化合物的生物活性，合成了一系列有机锗氨基酸酯类倍半氧化物，并重点研究了它们的快原子轰击质谱（ＦＡＢＭＳ）。研究结果表明：该系列化合物的各碎片离子峰与其组成及结构均有很好的对应关系及很强的规律性     

Clinical applications of chemiluminescence

This article reviews the clinical applications of chemiluminescence in routine testing and surveys the diverse applications of chemiluminescence in clinical research. In routine clinical testing, chemiluminescent labels (acridinium ester, acridinium sulfonamide) and detection reactions for peroxidase and alkaline phosphatase enzyme labels (luminol and adamantyl 1,2-dioxetane-based reactions, respectively) are widely used in immunoassay and nucleic acid probe assays (e.g. hybridization protection assay, Hybrid Capture^® assay). In clinical research the sensitivity, dynamic range and diversity of chemiluminescent assays has led to a vast range of applications, notably in protein and nucleic acid blotting, microarray-based assays, monitoring reactive oxygen species, and as detection reactions for substances separated by HPLC, capillary electrophoresis (CE), and flow-injection analysis.     

Synthesis and new rearrangements of 4-isoxazolin-4,5-dicarboxylic acid derivatives

Acyclic nitrones react with dimethyl acetylenedicarboxylate (DMAD) to give stable isoxazolines, from which the ones that contain electron-donating aromatic rings at the C3 position (R¹) were shown to undergo unprecedented fragmentation at room temperature, giving the R¹-aldehyde and inseparable product mixtures, probably due to the formation of highly reactive species such as iminocarbenes. Attempts to convert the isoxazolines to the corresponding stable azomethine ylides, by refluxing in toluene, again led to the same product mixtures as above (e.g., the room temperature decomposition). Isoxazolines when reacted with methoxide at room temperature afforded highly functionalised diastereomeric mixtures. Also, isoxazolines, when reacted with propylamine, gave the corresponding amides regioselectively, all of which were more stable than the parent isoxazolines.     

Conversion of N-Acyl-4-phenyl/benzyl-oxazolidine-2-thiones into Thiol Esters in the Presence of EtSH-K2CO3

N-Acyl-β-hydroxy-4-phenyl-oxazolidinethiones could be rapidly converted into their ethyl thiol esters in high yields by treatment with EtSH at 0 ℃ in CH3CN or 9 ： 1 （V ： V） THF-H2O in the presence of a catalytic amount of K2CO3.     

二价金属离子萃取速率常数与软硬酸碱规则

用上升液滴法测定了２－乙基己基膦酸单（２－乙基己基）酯－正辛烷从硝酸介质中萃取镁、钙、锌、镍、铜和铅等二价金属离子的正向初始速率，建立了速率方程，计算出正向萃取反应的速率常数、活化能及活化熵，首次将软硬酸碱规则与金属溶萃取速率常数关联。结果表明，在萃取机理相同时，萃取速率常数的大小与金属离子的软硬酸碱标度一致，即萃取过程中，作为酸的被萃取金属离子，其硬度越大，萃取速率常数亦越大，萃取反应的活化能…     

Synthese von ungesättigten und gesättigten Aminosäurederivaten durch kathodische Reduktion von Azidozimtsäureester

Cathodic reduction of -azidocinnamic ester under aprotic conditions on Hg, Pt, or graphite electrodes can be directed to high yields of N,N-diacylated dehydroaminoacid derivates (f.i. addition of acetic anhydride) or to almost quantitative yields of -aminocinnamic ester in very pure form by careful addition of H⁺-donors. The dehydroamino compounds in turn can be further reduced to the corresponding saturated compounds by following H⁺-addition and changed electrolysis potential. Almost no dimerization occurs.

     

锗甲基丙酰—α—氨基酸酯系列倍半氧化物的合成与表征

锗甲基丙酰氯与α－氨基酸酯反应继而水解得到４个新的锗甲基丙酰－α－氨基酸乙酯倍半氧化物，研究了其ＩＲ，＾ＨＮＭＲ和１３ＣＮＭＲ与氨基酸代基结构效应的关系。