全文获取类型
收费全文 | 696篇 |
免费 | 33篇 |
国内免费 | 29篇 |
专业分类
化学 | 648篇 |
晶体学 | 2篇 |
力学 | 8篇 |
综合类 | 18篇 |
数学 | 41篇 |
物理学 | 41篇 |
出版年
2024年 | 1篇 |
2023年 | 12篇 |
2022年 | 27篇 |
2021年 | 43篇 |
2020年 | 29篇 |
2019年 | 26篇 |
2018年 | 34篇 |
2017年 | 39篇 |
2016年 | 51篇 |
2015年 | 38篇 |
2014年 | 28篇 |
2013年 | 38篇 |
2012年 | 103篇 |
2011年 | 10篇 |
2010年 | 14篇 |
2009年 | 20篇 |
2008年 | 22篇 |
2007年 | 28篇 |
2006年 | 14篇 |
2005年 | 9篇 |
2004年 | 9篇 |
2003年 | 17篇 |
2002年 | 17篇 |
2001年 | 14篇 |
2000年 | 24篇 |
1999年 | 8篇 |
1998年 | 17篇 |
1997年 | 11篇 |
1996年 | 6篇 |
1995年 | 5篇 |
1994年 | 6篇 |
1993年 | 5篇 |
1992年 | 6篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1986年 | 10篇 |
1984年 | 2篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有758条查询结果,搜索用时 46 毫秒
51.
Islam Ullah Khan Tehseen Aman Muhammad Asif Iqbal Asrar Ahmad Kazi 《Mikrochimica acta》2000,134(1-2):27-31
Fluoxetine hydrochloride reacts with benzoyl peroxide and potassium iodide, after heating for 1 min at 30 °C, to give a blue
colour having maximum absorbance at 570 nm. The reaction is selective for fluoxetine with 0.01 mg/mL as visual limit of quantitation
and provides a basis for a new spectrophotometric determination. The colour reaction obeys Beer’s law from 0.1 mg/10 mL to
2.0 mg/10 mL of fluoxetine and the relative standard deviation is 0.68%. The qualitative assessment of tolerable amounts of
other drugs is also studied.
Received September 21, 1998. Revision September 10, 1999. 相似文献
52.
53.
A dammarane derivative dihydrojujubogenin-2-en-1-one, which possesses a skeleton and pharmacophore partially similar to those of Territrem B, a potent AChE inhibitor, was synthesized via three different paths. The anti-AChE activity of this compound and related analogue was measured. 相似文献
54.
Abundant basic pharmaceutical knowledge is involved in the detection of SARS-CoV-2 and the discovery and development of antiviral drugs. This paper gives detailed summary and provides rich materials for case teaching. 相似文献
55.
顾琼 《应用数学与计算数学学报》1997,(2)
对于群体决策问题,本文给出一个新的带参数的ακ-较多规则,并且讨论了在此规则下个体选优解和群体选优解的关系。此外,还论证了相应的ακ-较多规则满足Arrow公理的情况。 相似文献
56.
Sabry Mohamed Khalil 《Mikrochimica acta》2007,158(3-4):233-238
A simple, accurate, precise and sensitive method has been developed for the determination of Vardenafil (Vd) using direct
coupled plasma atomic emission spectrometry. The ion associates formed as a result of the reaction of vardenafil with ammonium
reineckate, Mn(II) and Co(II) thiocyanates and sodium cobaltinitrite are precipitated. The solubility of the solid complexes
under the optimum conditions of pH and ionic strength was studied. Saturated solutions of each ion associate at different
temperatures under the optimum precipitation conditions were prepared, and the metal ion content in the supernatant was determined.
The solubility products were thus calculated at different temperatures, and the thermodynamic parameters ΔH, ΔG and ΔS were
calculated. The method has been used for the determination of vardenafil (1.36–68.32 μg·mL−1) in pure solutions and in Levitra tablets. 相似文献
57.
58.
Shridhar H. Thorat Sanjay Kumar Sahu Rajesh G. Gonnade 《Acta Crystallographica. Section C, Structural Chemistry》2015,71(11):1010-1016
The synthesis of pharmaceutical cocrystals is a strategy to enhance the performance of active pharmaceutical ingredients (APIs) without affecting their therapeutic efficiency. The 1:1 pharmaceutical cocrystal of the antituberculosis drug pyrazinamide (PZA) and the cocrystal former p‐aminobenzoic acid (p‐ABA), C7H7NO2·C5H5N3O, (1), was synthesized successfully and characterized by relevant solid‐state characterization methods. The cocrystal crystallizes in the monoclinic space group P21/n containing one molecule of each component. Both molecules associate via intermolecular O—H...O and N—H...O hydrogen bonds [O...O = 2.6102 (15) Å and O—H...O = 168.3 (19)°; N...O = 2.9259 (18) Å and N—H...O = 167.7 (16)°] to generate a dimeric acid–amide synthon. Neighbouring dimers are linked centrosymmetrically through N—H...O interactions [N...O = 3.1201 (18) Å and N—H...O = 136.9 (14)°] to form a tetrameric assembly supplemented by C—H...N interactions [C...N = 3.5277 (19) Å and C—H...N = 147°]. Linking of these tetrameric assemblies through N—H...O [N...O = 3.3026 (19) Å and N—H...O = 143.1 (17)°], N—H...N [N...N = 3.221 (2) Å and N—H...N = 177.9 (17)°] and C—H...O [C...O = 3.5354 (18) Å and C—H...O = 152°] interactions creates the two‐dimensional packing. Recrystallization of the cocrystals from the molten state revealed the formation of 4‐(pyrazine‐2‐carboxamido)benzoic acid, C12H9N3O3, (2), through a transamidation reaction between PZA and p‐ABA. Carboxamide (2) crystallizes in the triclinic space group P with one molecule in the asymmetric unit. Molecules of (2) form a centrosymmetric dimeric homosynthon through an acid–acid O—H...O hydrogen bond [O...O = 2.666 (3) Å and O—H...O = 178 (4)°]. Neighbouring assemblies are connected centrosymmetrically via a C—H...N interaction [C...N = 3.365 (3) Å and C—H...N = 142°] engaging the pyrazine groups to generate a linear chain. Adjacent chains are connected loosely via C—H...O interactions [C...O = 3.212 (3) Å and C—H...O = 149°] to generate a two‐dimensional sheet structure. Closely associated two‐dimensional sheets in both compounds are stacked via aromatic π‐stacking interactions engaging the pyrazine and benzene rings to create a three‐dimensional multi‐stack structure. 相似文献
59.
Jessica Orrego Hernandez Jaime Portilla Justo Cobo Christopher Glidewell 《Acta Crystallographica. Section C, Structural Chemistry》2015,71(5):363-368
Cyclohexylamine reacts with 5‐chloro‐3‐methyl‐1‐(pyridin‐2‐yl)‐1H‐pyrazole‐4‐carbaldehyde to give 5‐cyclohexylamino‐3‐methyl‐1‐(pyridin‐2‐yl)‐1H‐pyrazole‐4‐carbaldehyde, C16H20N4O, (I), formed by nucleophilic substitution, but with 5‐chloro‐3‐methyl‐1‐phenyl‐1H‐pyrazole‐4‐carbaldehyde the product is (Z)‐4‐[(cyclohexylamino)methylidene]‐3‐methyl‐1‐phenyl‐1H‐pyrazol‐5(4H)‐one, C17H21N3O, (II), formed by condensation followed by hydrolysis. Compound (II) crystallizes with Z′ = 2, and in one of the two independent molecular types the cyclohexylamine unit is disordered over two sets of atomic sites having occupancies of 0.65 (3) and 0.35 (3). The vinylogous amide portion in each compound shows evidence of electronic polarization, such that in each the O atom carries a partial negative charge and the N atom of the cyclohexylamine portion carries a partial positive charge. The molecules of (I) contain an intramolecular N—H...N hydrogen bond, and they are linked by C—H...O hydrogen bonds to form sheets. Each of the two independent molecules of (II) contains an intramolecular N—H...O hydrogen bond and each molecular type forms a centrosymmetric dimer containing one R22(4) ring and two inversion‐related S(6) rings. 相似文献
60.
Inversion twinning in a second polymorph of the hydrochloride salt of the recreational drug ethylone
T. Stanley Cameron J. Stuart Grossert Chad R. Maheux Idralyn Q. Alarcon Catherine R. Copeland Anthony Linden 《Acta Crystallographica. Section C, Structural Chemistry》2015,71(4):266-270
A second polymorph of the hydrochloride salt of the recreational drug ethylone, C12H16NO3+·Cl−, is reported [systematic name: (±)‐2‐ethylammonio‐1‐(3,4‐methylenedioxyphenyl)propane‐1‐one chloride]. This polymorph, denoted form (A), appears in crystallizations performed above 308 K. The originally reported form (B) [Wood et al. (2015). Acta Cryst. C 71 , 32–38] crystallizes preferentially at room temperature. The conformations of the cations in the two forms differ by a 180° rotation about the C—C bond linking the side chain to the aromatic ring. Hydrogen bonding links the cations and anions in both forms into similar extended chains in which any one chain contains only a single enantiomer of the chiral cation, but the packing of the ions is different. In form (A), the aromatic rings of adjacent chains interleave, but pack equally well if neighbouring chains contain the same or opposite enantiomorph of the cation. The consequence of this is then near perfect inversion twinning in the structure. In form (B), neighbouring chains are always inverted, leading to a centrosymmetric space group. The question as to why the polymorphs crystallize at slightly different temperatures has been examined by density functional theory (DFT) and lattice energy calculations and a consideration of packing compactness. The free energy (ΔG) of the crystal lattice for polymorph (A) lies some 52 kJ mol−1 above that of polymorph (B). 相似文献