改进二元分布估计算法求解置换流水车间调度问题

针对置换流水车间调度这类组合最优化问题的求解,提出了一种改进二元分布估计算法(Improved binary estimation distribution algorithm, I-EDA)。算法以二元分布估计算法为架构,使用NEH(Nawaz-Enscore-Ham)启发式算法生成初始解,提高了初始解的质量;通过对优势解的统计采样构建位置矩阵模型和链接矩阵模型,依照两个矩阵模型的合并概率组合链接区块产生子代。提出了NEH插入式重组策略和基于位置概率的交换策略和两种全新局部搜索机制替代原二元分布估计算法的相邻交换法,以进一步筛选优势解。最后通过对Reeves标准测试集的仿真实验和算法比较验证了所提出算法的有效性。     

The spectrum of α‐resolvable designs with block size four

Abstact: An α‐resolvable BIBD is a BIBD with the property that the blocks can be partitioned into disjoint classes such that every class contains each point of the design exactly α times. In this paper, we show that the necessary conditions for the existence of α‐resolvable designs with block size four are sufficient, with the exception of (α, ν, λ) = (2, 10, 2). © 2000 John Wiley & Sons, Inc. J Combin Designs 9: 1–16, 2001     

On e-cuspidal pairs of finite groups of exceptional Lie type

Let G be a simple, simply connected algebraic group of exceptional type defined over ${\mathbb{F}}_q$ with Frobenius endomorphism $F:G\to G$. Let $??q$ be a good prime for G. We determine the number of irreducible Brauer characters in the quasi-isolated ?-blocks of $G^F$. This is done by proving that generalized e-Harish-Chandra theory holds for the Lusztig series associated to quasi-isolated elements of $G^{?F}$.     

A simple reaction to produce small structurally complex and diverse molecules

In order to mimic the complexity of natural products, we designed and obtained with simple synthetic methods, building blocks with `quaternary chiral centers'. These tricyclic lactams resulted from the reaction of a functional γ-keto-acid and various commercially available bi-nucleophiles.     

Perfect and nearly perfect silsesquioxane (SQs) nanoconstruction sites and Janus SQs

Cubic silsesquioxanes (SQs) offer perfect and nearly perfect 3-D symmetry with eight functional groups with each functional group occupying a different octant in Cartesian space. This paper is concerned with the synthesis of both highly symmetrical octa-monofunctional SQs and statistically bifunctional SQs wherein because of similar properties each functionality separates to one side of the cubically symmetric SQ giving Janus-like behavior. In the latter case we find these materials to offer novel properties of use in making both coatings with controlled contact angles ranging from 50–120 °C, with hardnesses (pencil) as high as 6H and the opportunity to make layer-by-layer coatings.     

渗流方程自适应非均匀网格Dagan粗化算法

在粗网格内先统计渗透率在粗网格中的概率分布，利用Dagan渗透率粗化积分方程通过渗透率概率分布计算粗化网格的等效渗透率，并由等效渗透率计算了粗化网格的压强分布，计算压强时还将渗透率自适应网格技术应用于三维渗流方程的网格粗化算法中，在渗透率或孔隙度变化异常区域自动采用精细网格，用直接解法求解渗透率或孔隙度变化异常区域的压强分布。整个求解区采用不均匀网格粗化，在流体流速高的区域采用精细网格。利用本文方法计算了三维渗流方程的压强分布，结果表明这种算法的解在渗透率或孔隙度异常区的压强分布规律非常逼近精细网格的解，在其他区域压强分布规律非常逼近粗化算法的解，计算速度比采用精细网格提高了约100倍。     

Aldo‐X Bifunctional Building Blocks for the Synthesis of Heterocycles

Compounds containing oxygen, nitrogen, or sulfur atoms inside the rings are attracting much attention and interest due to their biological importance. In recent years, several methods for the synthesis of such molecules have been reported by using aldo‐X bifunctional building blocks (AXB3 s) as substrates; these are a wide class of organic molecules that contain at least two reactive sites, among them, one aldehyde, acetal, or semiacetal group was involved. Because of the multiple reactivities, AXB3 s are widely used in the one‐pot synthesis of biologically important heterocycles. This review summarizes the synthesis of important heterocycles by using AXB3 s as pivotal components in establishing multicomponent reactions, tandem reactions, and so forth. In many cases, the established reaction systems with AXB3 s were characterized by some green properties, such as easy access to the substrate, mild and environmentally benign conditions, and wide scope of the substrate.     

5‐Formyluracil as a Multifunctional Building Block in Biosensor Designs

In organisms 5‐formyluracil (5fU), which is known as a vital natural nucleobase, is widely present. Despite the recent development of sensor designs for organic fluorescent molecules for selective targeting applications, biocompatible and easily operated probe designs that are based on natural nucleobase modifications have rarely been reported. Here, we introduce the idea of 5fU as a multifunctional building block to facilitate the design and synthetic development of biosensors. The azide group was derived from the sugar of a nucleoside, which can be further used in the selective binding of cells or organelles through click chemistry with alkynyl‐modified targeting groups. The aldehyde group of 5fU can react with different chemicals to generate environmentally sensitive nucleobases that have obvious characteristics, which precious reactants cannot achieve for selective fluorogenic switch‐on detection of a specific target. We first synthesized 5fU analogues that had aggregation‐induced emission properties, and then we used triphenylphosphonium as a mitochondria‐targeting group to selectively image mitochondria in cancer cells and mouse embryonic stem cells. Additionally, the reagents exhibit a high selectivity for reaction with 5fU, which means that the method can also be used for the detection of 5fU. Combining the two characteristics, the idea of 5fU as a multifunctional building block in biosensor designs may potentially be applicable in 5fU site‐specific microenvironment detection in future research.