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排序方式: 共有171条查询结果,搜索用时 109 毫秒
41.
Dr. Jan Zaminer Dr. Christoph Brockmann Dipl.‐Chem. Peter Huy Dipl.‐Biophys. Robert Opitz Dipl.‐Chem. Cédric Reuter Dr. Michael Beyermann Priv.‐Doz. Dr. Christian Freund Dipl.‐Biochem. Matthias Müller Prof. Dr. Hartmut Oschkinat Dr. Ronald Kühne Prof. Dr. Hans‐Günther Schmalz 《Angewandte Chemie (International ed. in English)》2010,49(39):7111-7115
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The current contribution serves as a critical update to a previous feature article from us (Macromol. Rapid Commun. 2012 , 33, 958−971), and highlights the latest advances in the preparation of single chain polymeric nanoparticles and initial—yet promising—attempts towards mimicking the structure of natural biomacromolecules via single‐chain folding of well‐defined linear polymers via so‐called single chain selective point folding and repeat unit folding. The contribution covers selected examples from the literature published up to ca. September 2015. Our aim is not to provide an exhaustive review but rather highlight a selection of new and exciting examples for single‐chain folding based on advanced macromolecular precision chemistry. Initially, the discussion focuses on the synthesis and characterization of single‐chain folded structures via selective point folding. The second part of the feature article addresses the folding of well‐defined single‐chain polymers by means of repeat unit folding. The current state of the art in the field of single‐chain folding indicates that repeat unit folding‐driven nanoparticle preparation is well‐advanced, while initial encouraging steps towards building selective point folding systems have been taken. In addition, a summary of the—in our view—open key questions is provided that may guide future biomimetic design efforts.
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Thorfinnur Gunnlaugsson R. Jeremy H. Davies Paul Jensen Sinead Mulready Clarke S. Stevenson 《Tetrahedron letters》2005,46(21):3761-3766
The cyclen based pyridine complexes 1Ln-3Ln (Ln = La(III) and Eu(III)) were synthesised as metallo-ribonuclease mimics and their ability to hydrolytically cleave the phosphodiester of HPNP at 37 °C was investigated using UV-vis spectroscopy, whereas the binding of the substrate was evaluated using 31P NMR and Eu(III)-luminescent measurements. In contrast 2La gave rise to fast pH dependent hydrolysis of HPNP, with maximum efficiency at ca. pH 8.2, and with a half-lifetime of ∼1 h, the 1Ln and 3Ln complexes were found to be inactive, emphasizing the importance of the nature of the pyridine isomer as a cofactor in the hydrolytic process. 相似文献
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The design, atomic characterization, performance, and relevance to clean technology of two distinct categories of new nanocatalysts are described and interpreted. Exceptional molecular selectivity and high activity are exhibited by these catalysts. The first category consists of extended, crystallographically ordered inorganic solids possessing nanopores (apertures, cages, and channels), the diameters of which fall in the range of about 0.4 to about 1.5 nm, and the second of discrete bimetallic nanoparticles of diameter 1 to 2 nm, distributed more or less uniformly along the inner walls of mesoporous (ca. 3 to 10 nm diameter) silica supports. Using the principles and practices of solid-state and organometallic chemistry and advanced physico-chemical techniques for in situ and ex situ characterization, a variety of powerful new catalysts has been evolved. Apart from those that, inter alia, simulate the behavior of enzymes in their specificity, shape selectivity, regio-selectivity, and ability to function under ambient conditions, many of these new nanocatalysts are also viable as agents for effecting commercially significant processes in a clean, benign, solvent-free, single-step fashion. In particular, a bifunctional, molecular sieve nanopore catalyst is described that converts cyclohexanone in air and ammonia to its oxime and caprolactam, and a bimetallic nanoparticle catalyst that selectively converts cyclic polyenes into desirable intermediates. Nanocatalysts in the first category are especially effective in facilitating highly selective oxidations in air, and those in the second are well suited to effecting rapid and selective hydrogenations of a range of organic compounds. 相似文献
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Breslow R 《Chemical record (New York, N.Y.)》2001,1(1):3-11
Synthetic organic chemistry normally achieves selectivity by manipulation of the intrinsic reactivity of the substrate, but enzyme use is quite a different principle. The geometry of the enzyme-substrate complex determines enzymatic selectivity, completely overwhelming any normal selective reactivities. Biomimetic chemistry aims to imitate the enzymatic style. Some early approaches used attached reagents or templates to direct photochemical and free radical processes, with a combination of geometric and reactivity control. Recent work uses a mimic of the enzyme class cytochrome P-450 to achieve the selective hydroxylations of steroids with complete domination by the geometry of the catalyst-substrate complex. 相似文献
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Flavin Derivatives with Tailored Redox Properties: Synthesis,Characterization, and Electrochemical Behavior 下载免费PDF全文
Attila Kormányos Mohammad S. Hossain Ghazaleh Ghadimkhani Joe J. Johnson Prof. Csaba Janáky Prof. Norma R. de Tacconi Prof. Frank W. Foss Jr. Prof. Yaron Paz Prof. Krishnan Rajeshwar 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(27):9209-9217
This study establishes structure–property relationships for four synthetic flavin molecules as bioinspired redox mediators in electro‐ and photocatalysis applications. The studied flavin compounds were disubstituted with polar substituents at the N1 and N3 positions (alloxazine) or at the N3 and N10 positions (isoalloxazines). The electrochemical behavior of one such synthetic flavin analogue was examined in detail in aqueous solutions of varying pH in the range from 1 to 10. Cyclic voltammetry, used in conjunction with hydrodynamic (rotating disk electrode) voltammetry, showed quasi‐reversible behavior consistent with freely diffusing molecules and an overall global 2e?, 2H+ proton‐coupled electron transfer scheme. UV/Vis spectroelectrochemical data was also employed to study the pH‐dependent electrochemical behavior of this derivative. Substituent effects on the redox behavior were compared and contrasted for all the four compounds, and visualized within a scatter plot framework to afford comparison with prior knowledge on mostly natural flavins in aqueous media. Finally, a preliminary assessment of one of the synthetic flavins was performed of its electrocatalytic activity toward dioxygen reduction as a prelude to further (quantitative) studies of both freely diffusing and tethered molecules on various electrode surfaces. 相似文献