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11.
Giuseppe Caruso 《Molecules (Basel, Switzerland)》2022,27(10)
Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous dipeptide and an over-the-counter food supplement with a well-demonstrated multimodal mechanism of action that includes the detoxification of reactive oxygen and nitrogen species, the down-regulation of the production of pro-inflammatory mediators, the inhibition of aberrant protein formation, and the modulation of cells in the peripheral (macrophages) and brain (microglia) immune systems. Since its discovery more than 100 years ago, a plethora of in vivo preclinical studies have been carried out; however, there is still substantial heterogeneity regarding the route of administration, the dosage, the duration of the treatment, and the animal model selected, underlining the urgent need for “coordinated/aligned” preclinical studies laying the foundations for well-defined future clinical trials. The main aim of the present position paper is to critically and concisely consider these key points and open a discussion on the possible “alignment” for future studies, with the goal of validating the full therapeutic potential of this intriguing molecule. 相似文献
12.
H. A. Das 《Isotopes in environmental and health studies》2013,49(5):241-244
The leaching of microconstituents from granular solid wastes is often studied by column experiments. The underlying assumption is that the flow is of the one-compartment or “backmix” type. The influence of small deviations from this ideal situation on the outcome of the leaching experiment depends slightly on the specific mass-transfer function of the trace involved. The deviation itself may be measured by a simple separate radiotracer experiment. 相似文献
13.
J. Šulc 《Isotopes in environmental and health studies》2013,49(7):254-256
On the basis of a simplified mathematical model there is calculated the probability of a photon of characteristic K series radiation excited by a photon of low energy gamma radiation hitting the detector. There are also included the probabilities for coherently and incoherently scattered primary radiation considering electron binding energies. 相似文献
14.
B. Emmoth 《辐射效应与固体损伤》2013,168(1-4):365-379
At doses close to threshold for exfoliation or bubble formation the surfaces have been investigated by SEM and, after isolation of surface layers, also by RBS. Swelling as a function of energy and material has been determined. The data are interpreted in the form of volume occupied by a helium atom. We find an indication for a volume decrease with increasing energy. A special example of blister formation is also discussed, where we find evidence for a non-uniform fracture plane. 相似文献
15.
16.
N. Angelescu M. Bundaru G. Costache C. J. Thompson 《Journal of statistical physics》1986,43(1-2):33-49
A generalizedO(n) matrix version of the classical Heisenberg model, introduced by Fuller and Lenard as a classical limit of a quantum model, is solved exactly in one dimension. The free energy is analytic and the pair correlation functions decay exponentially for all finite temperatures. It is shown, however, that even for a finite number of spins the model has a phase transition in then limit. The transition features a specific heat jump, zero long-range order at all temperatures, and zero correlation length at the critical point. The Curie-Weiss version of the model is also solved exactly and shown to have standard mean-field type behavior for all finiten and to differ from the one-dimensional results in then limit. 相似文献
17.
We use a mathematical isomorphism between the one-dimensional exclusion process and the two-dimensional stochastic Ising model in the low-temperature limit to describe the typical instantaneous shape of a supercritical droplet. We derive, specifically, the exact asymptotic distribution of the boundaries of a (+1) spin region, confined to Z
+
2
and subjected to a positive magnetic field. In an appropriate scaling, the boundary distribution converges to a deterministic continuum limit.On leave at the EPFL, CH-1015 Lausanne, Switzerland. 相似文献
18.
Simulations in lattices of size 1003 at the critical point of the three-dimensional Glauber kinetic Ising model indicate that the 1935 Becker-Doring equation no longer works there: The growth rates decay in time. These conclusions confirm those in two dimensions. 相似文献
19.
N. G. Fytas A. Malakis 《The European Physical Journal B - Condensed Matter and Complex Systems》2006,50(1-2):39-43
The three-dimensional bimodal random-field Ising model is studied
via a new finite temperature numerical approach. The methods of
Wang-Landau sampling and broad histogram are implemented in a
unified algorithm by using the N-fold version of the Wang-Landau
algorithm. The simulations are performed in dominant energy
subspaces, determined by the recently developed critical minimum
energy subspace technique. The random-fields are obtained from a
bimodal distribution, that is we consider the discrete
(±Δ) case and the model is studied on cubic lattices with
sizes 4≤L ≤20. In order to extract information for the
relevant probability distributions of the specific heat and
susceptibility peaks, large samples of random-field realizations
are generated. The general aspects of the model's scaling behavior
are discussed and the process of averaging finite-size anomalies
in random systems is re-examined under the prism of the lack of
self-averaging of the specific heat and susceptibility of the
model. 相似文献
20.
We introduce a velocity-difference-separation model that modifies the previous
models in the literature. The improvement of this new model over the previous ones
lies in that it not only theoretically retains many strong points of the previous
ones, but also performs more realistically than others in the dynamical evolution of
congestion. Furthermore, the proposed model is investigated with analytic and
numerical methods, with the finding that it can demonstrate some complex physical
features observed in real traffic such as the existence of three phases: free flow,
synchronized flow, and wide moving jam; sudden flow drop in flow-density plane; and
traffic hysteresis in transition between the free and the synchronized flow. 相似文献