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排序方式: 共有147条查询结果,搜索用时 15 毫秒
141.
Carl A. Denard Dr. Hua Huang Dr. Mark J. Bartlett Lu Lu Dr. Yichen Tan Prof. Huimin Zhao Prof. John F. Hartwig 《Angewandte Chemie (International ed. in English)》2014,53(2):465-469
Although chemical and enzymatic catalysts have been combined, reactions in which an organometallic catalyst and a metalloenzyme work cooperatively to create products, which cannot be generated with either catalyst alone or in comparable yields by sequential reactions of the two catalysts, have not been reported. Such reactions are challenging to achieve, in part because the milieu in which these catalysts operate are typically different. Herein, two classes of catalysts are demonstrated to react cooperatively in the same system. Combination of a metathesis catalyst and a P450 enzyme lead to a dynamic equilibration of alkenes and a selective epoxidation of the cross‐metathesis products. These results show the potential of combining the two classes of catalysts for synthetic transformations. 相似文献
142.
Formation of High‐Valent Iron–Oxo Species in Superoxide Reductase: Characterization by Resonance Raman Spectroscopy
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Dr. Florence Bonnot Dr. Emilie Tremey Dr. David von Stetten Dr. Stéphanie Rat Dr. Simon Duval Dr. Philippe Carpentier Dr. Martin Clemancey Dr. Alain Desbois Dr. Vincent Nivière 《Angewandte Chemie (International ed. in English)》2014,53(23):5926-5930
Superoxide reductase (SOR), a non‐heme mononuclear iron protein that is involved in superoxide detoxification in microorganisms, can be used as an unprecedented model to study the mechanisms of O2 activation and of the formation of high‐valent iron–oxo species in metalloenzymes. By using resonance Raman spectroscopy, it was shown that the mutation of two residues in the second coordination sphere of the SOR iron active site, K48 and I118, led to the formation of a high‐valent iron–oxo species when the mutant proteins were reacted with H2O2. These data demonstrate that these residues in the second coordination sphere tightly control the evolution and the cleavage of the O? O bond of the ferric iron hydroperoxide intermediate that is formed in the SOR active site. 相似文献
143.
Thomas J. Carruthers Dr. Paul D. Carr Dr. Choy‐Theng Loh Dr. Colin J. Jackson Prof. Gottfried Otting 《Angewandte Chemie (International ed. in English)》2014,53(51):14269-14272
Heterodinuclear metalloenzymes are an important class of metalloproteins, but determining the location of the different metal ions can be difficult. Herein we present a new NMR spectroscopy method that uses pseudocontact shifts (PCS) to achieve this without assumptions about the coordinating ligands. The approach is illustrated with the dinuclear [FeZn] complex of IMP‐1, which is a prototypical metallo‐β‐lactamase (MβL) that confers resistance to β‐lactam antibiotics. Results from single‐crystal X‐ray diffraction were compromised by degradation during crystallization. With [GaZn]‐IMP‐1 as diamagnetic reference, the PCSs unambiguously identified the iron binding site in fresh samples of [FeZn]‐IMP‐1, even though the two metal centers are less than 3.8 Å apart and the iron is high‐spin Fe3+, which produces only small PCSs. [FeZn]‐MβLs may be important drug targets, as [FeZn]‐IMP‐1 is enzymatically active and readily produced in the presence of small amounts of Fe3+. 相似文献
144.
Hiroyasu Tabe Dr. Satoshi Abe Tatsuo Hikage Prof. Dr. Susumu Kitagawa Prof. Dr. Takafumi Ueno 《化学:亚洲杂志》2014,9(5):1373-1378
Porous protein crystals, which are protein assemblies in the solid state, have been engineered to form catalytic vessels by the incorporation of organometallic complexes. Ruthenium complexes in cross‐linked porous hen egg white lysozyme (HEWL) crystals catalyzed the enantioselective hydrogen‐transfer reduction of acetophenone derivatives. The crystals accelerated the catalytic reaction and gave different enantiomers based on the crystal form (tetragonal or orthorhombic). This method represents a new approach for the construction of bioinorganic catalysts from protein crystals. 相似文献
145.
Willis B Eubanks LM Dickerson TJ Janda KD 《Angewandte Chemie (International ed. in English)》2008,47(44):8360-8379
In the classic novella "The Strange Case of Dr. Jekyll and Mr. Hyde", Robert Louis Stevenson paints a stark picture of the duality of good and evil within a single man. Botulinum neurotoxin (BoNT), the most potent known toxin, possesses an analogous dichotomous nature: It shows a pronounced morbidity and mortality, but it is used with great effect in much lower doses in a wide range of clinical scenarios. Recently, tremendous strides have been made in the basic understanding of the structure and function of BoNT, which have translated into widespread efforts towards the discovery of biomacromolecules and small molecules that specifically modulate BoNT activity. Particular emphasis has been placed on the identification of inhibitors that can counteract BoNT exposure in the event of a bioterrorist attack. This Review summarizes the current advances in the development of therapeutics, including vaccines, peptides, and small-molecule inhibitors, for the prevention and treatment of botulism. 相似文献
146.
147.
L. Govindasamy V. Rajakannan D. Velmurugan S. Shanmuga Sundara Raj T. M. Rajendran R. Venkatesan R. Srinivasan H. K. Fun 《Crystal Research and Technology》2002,37(9):1018-1028
The crystal structure of the title complex has been solved using X‐ray diffraction data.The compound crystallizes from aqueous ethanol solvent in the triclinic system, space group P‐1, with unit cell parameters: a = 8.9532(1), b = 12.7423(3), c = 14.9012(3) Å, α = 73.767(1), β = 75.322(1), γ = 77.496(1)°, Z = 2, V = 1559.4(5) Å3. The trial structure was determined by automated Patterson methods and subsequent difference Fourier techniques using DIRDIF98 and refined to a final R‐factor of 0.064. The copper ion Cu1 adopts a (4+1) square‐pyramidal geometry defined by the tridentate N‐salicylidimine dianions and the neutral monodentate pyridine ligand in the basal plane. The apical position is occupied by a solvent methanol molecule at a distance of 2.341(4) Å. The copper Cu2 adopts a square‐planar geometry. 相似文献