排序方式: 共有54条查询结果,搜索用时 15 毫秒
31.
A. Yu. Liakina A. A. Formanovsky I. S. Popova I. V. Mikhura 《Chemistry of Heterocyclic Compounds》2005,41(7):877-882
The interaction of anions, obtained by treating 2,4,5-trimethylthiazole and 2,5-dimethyl-4-phenylthiazole with butyllithium,
with aliphatic and aromatic aldehydes leads to substituted 2-thiazolyl-1-ethanols. It was established that the metallation
reaction occurs at the 2-methyl group of the thiazoles.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1038–1043, July, 2005. 相似文献
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Bubnov Yu. N. Pastukhov F. V. Starikova Z. A. Ignatenko A. V. 《Russian Chemical Bulletin》2001,50(11):2172-2182
Allylmetallation of isoquinolines, quinoline, and quinoxaline with allylic derivatives of zinc was examined for the first time. A convenient procedure was discovered and developed for the synthesis of 1,4-ethano-2,3-dihydroisoquinolines based on the reactions of isoquinolines with allylic derivatives of zinc. This multistage process involves double allylmetallation of the heterocyclic ring followed by cyclization through intramolecular carbometallation of the C=C bond. The structures of three key derivatives of 1,4-ethano-2,3-dihydroisoquinoline were established by X-ray diffraction analysis. The reactions of quinoxaline with allyl- and methallylzinc bromide proceeded stereospecifically to form trans-2,3-diallylated 1,2,3,4-tetrahydroquinoxalines. Heating of quinoline with methallylzinc bromide in THF afforded 4-methallylquinoline in nearly quantitative yield. The initially formed 1,4-metallation product underwent aromatization through elimination of HZnBr. 相似文献
34.
Soumita Mukherjee 《合成通讯》2013,43(13):1939-1943
Direct metallation of 2,4-dialkoxy-5-bromopyrimidine with lithium diisopropylamide and consequent trapping by dimethylformamide resulted unexpectedly in the formation of 2,6-dialkoxy-5-dimethylaminopyrimidine-4-carboxaldehyde via displacement of bromine by dimethylamine moiety of dimethylformamide. 相似文献
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Tomasz Goslinski Matthew J. Fuchter Anthony G.M. Barrett Brian M. Hoffman 《Tetrahedron letters》2009,50(37):5178-321
We report the synthesis and characterization of structurally unusual porphyrazine triads with three macrocycles bound to a central pyrazine core. These trimacrocyclic complexes were accidentally discovered during studies on the peripheral metallation of porphyrazinediamines. The crystal structure of the tri-zinc porphyrazine triad is described and the spectroscopic properties including electronic absorption spectra of this complex and the corresponding magnesium, free-base, and copper derivatives are reported. 相似文献
36.
Novel regioselective methods have been developed for the mono‐ and difunctionalization of alkyl groups containing 1‐phenylpyrroles using different organometallic reagents. Tailoring the reagents and conditions allowed us to prepare several new mono‐ and rotationally restricted dicarboxylic acid derivatives of 1‐(alkylphenyl)pyrroles in good yields. 相似文献
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Givaja G Volpe M Leeland JW Edwards MA Young TK Darby SB Reid SD Blake AJ Wilson C Wolowska J McInnes EJ Schröder M Love JB 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(13):3707-3723
The syntheses, characterisation and complexation reactions of a series of binucleating Schiff-base calixpyrrole macrocycles are described. The acid-templated [2+2] condensations between meso-disubstituted diformyldipyrromethanes and o-phenylenediamines generate the Schiff-base pyrrolic macrocycles H(4)L(1) to H(4)L(6) upon basic workup. The single-crystal X-ray structures of both H(4)L(3).2 EtOH and H(4)L(6).H2O confirm that [2+2] cyclisation has occurred, with either EtOH or H2O hydrogen-bonded within the macrocyclic cleft. A series of complexation reactions generate the dipalladium [Pd2(L)] (L=L(1) to L(5)), dinickel [Ni2(L(1))] and dicopper [Cu2(L)] (L=L(1) to L(3)) complexes. All of these complexes have been structurally characterised in the solid state and are found to adopt wedged structures that are enforced by the rigidity of the aryl backbone to give a cleft reminiscent of the structures of Pacman porphyrins. The binuclear nickel complexes [Ni2(mu-OMe)2Cl2(HOMe)2(H(4)L(1))] and [Ni2(mu-OH)2Cl2(HOMe)(H(4)L(5))] have also been prepared, although in these cases the solid-state structures show that the macrocyclic ligand remains protonated at the pyrrolic nitrogen atoms, and the Ni(II) cations are therefore co-ordinated by the imine nitrogen atoms only to give an open conformation for the complex. The dicopper complex [Cu2(L(3))] was crystallised in the presence of pyridine to form the adduct [Cu2(py)(L(3))], in which, in the solid state, the pyridine ligand is bound within the binuclear molecular cleft. Reaction between H(4)L(1) and [Mn(thf){N(SiMe(3))2}2] results in clean formation of the dimanganese complex [Mn2(L(1))], which, upon crystallisation, formed the mixed-valent complex [Mn2(mu-OH)(L(1))] in which the hydroxo ligand bridges the metal centres within the molecular cleft. 相似文献
38.
Julia Kuchar Katharina Reinhold Vera Rsgen Nils Nthling Christian W. Lehmann Fabian Mohr 《Molecules (Basel, Switzerland)》2021,26(24)
A series of 2-arylamino-1,3-selenazoles was synthesized and their reactivity was studied. The 2-arylamino-1,3-selenazoles and their reaction products were characterized by various spectroscopic methods and X-ray diffraction. In addition, the antimicrobial activity of the 2-arylamino-1,3-selenazoles in a panel of seven bacteria and fungi was examined. 相似文献
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Frédéric ToudicArnault Heynderickx Nelly Plé Alain TurckGuy Quéguiner 《Tetrahedron》2003,59(33):6375-6384
Starting from fluoropyrazine, a general synthetic route including metallation and palladium-catalyzed cross-coupling reactions is described to access to rod-like alkylaryl or diarylpyrazines. Among them, some have liquid crystalline properties. 相似文献