屯田余绪中的近世边疆社会嬗变—以1719至1949年间甘肃省金塔县水利事务为中心的研究

以公元1719至1949年间甘肃金塔县水利事务为主线,可以分析这一因屯田而兴起的边疆社会在两百余年间的演化特征。清代屯田时期,金塔县水利事务完全由政府控制,屯田结束后逐渐转向民间自行管理;但政府却出于对边疆地区民众领袖易引发社会不稳定的成见,刻意将士绅集团排斥于水利管理事务之外。民国时期随着外源性水利危机的爆发,向外部“争水”成为决定区域社会生死存亡的头等大事,政府转而支持士绅阶层积极“争水”,士绅由此控制了全县水利事务。“争水”成功的士绅阶层很快涣散并劣化,致使金塔内部水利逐渐废弛、社会矛盾重重,并非迫切的“对外争水”成为凝聚区域社会的唯一共识。从屯田到争水,金塔社会在近世大多数时间中始终为单一维度社会管制目标所牵引,并未走上繁荣、有序、富于活力的发展之路。这其中涉及政治、环境等复杂因素的交相作用,但自屯田时代所遗留的制度化要素扮演了重要角色。短时期的屯田活动,造就了长时期存在于边疆区域的“屯田社会”,其流风余绪影响至今。     

基于MODIS数据的卫星辐射特性研究

本文提出了一种结合MODIS数据产品和MODTRAN模型的典型地形条件空间目标红外辐射特性计算方法.考虑了地形条件和大气环境对空间目标的红外辐射特性影响,应用MODIS 3级陆地,海洋,冰雪圈数据产品得到全球温度分布,地形特征分布,将温度及地形条件代入MODTRAN计算得到地表-目标的辐亮度,进而计算目标的外热流以及表...     

Rapid analysis of phthalic acid esters in environmental water using fast elution gas chromatography with mass spectrometry and adaptive library spectra

A method for the fast determination of the components in a complex sample by using gas chromatography with mass spectrometry was developed and used for the quantitative analysis of phthalic acid esters in environmental water. In the method, the adaptively corrected mass spectra were used to compensate for the differences between the library spectra and the measured ones in the experiment. The correction was obtained by the iterative transformation of the library spectra using iterative target transformation factor analysis, and the resolution was performed by non‐negative immune algorithm using the corrected spectra. Rapid analysis of 16 phthalic acid esters in water samples was achieved using fast elution gas chromatography with mass spectrometry measurements. The results show that the mass spectra and chromatographic profiles of the phthalic acid esters can be obtained from the overlapping signal of 13 min elution, and accurate quantitative analysis can be obtained. The recoveries of the phthalic acid esters obtained by standard addition are between 90.3 and 107.4%, and the relative standard deviations obtained in repeated measurements are less than 9%.     

Synthesis and characterization of folic acid‐modified carboxymethyl chitosan‐ursolic acid targeted nano‐drug carrier for the delivery of ursolic acid and 10‐hydroxycamptothecin

Carboxymethyl chitosan (CMCS), as a water‐soluble, biocompatible, and biodegradable polymer, is an excellent carrier for a sustained drug delivery system. In this study, a amphiphilic carboxymethyl chitosan‐ursolic acid nano‐drug carrier modified by folic acid (FPCU) were prepared, and then the nano‐drug carrier wrapped another anticancer drug 10‐hydroxycamptothecin were self‐assembled into nanoparticles (FPCU/HCPT NPs). The FPCU/HCPT NPs had a suitable size, high drug loading efficiency of ursolic acid (6.4%) and 10‐hydroxycamptothecin (14.1%). The drug release study in vitro indicated that the nanoparticles have obviously sustained effect and pH sensitive behaviors, the drug release amount was higher at pH 5.5 than at pH 7.4. in vitro and in vivo study showed that the nanoparticles displayed a high antitumor efficiency to tumor cells compared with free drug. The nano delivery system as a carrier for ursolic acid (UA) and 10‐hydroxycamptothecin (HCPT) has good application prospects in cancer treatment.     

α-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer

α-Trifluoromethyl chalcones were prepared and evaluated for their antiproliferative activities against androgen-independent prostate cancer cell lines as well as five additional types of human tumor cell lines. The most potent chalcone 5 showed superior antitumor activity in vivo with both oral and intraperitoneal administration at 3 mg/kg. Cell-based mechanism of action studies demonstrated that 5 induced cell accumulation at sub-G1 and G2/M phases without interfering with microtubule polymerization. Furthermore, several cancer cell growth-related proteins were identified by using chalcone 5 as a bait for the affinity purification of binding proteins.     

基于酶辅助靶标循环的适体传感器灵敏检测中药中黄曲霉毒素B1

该文基于酶辅助靶标循环信号放大策略构建了用于黄曲霉毒素B1(AFB1)高灵敏检测的化学发光适体传感器。以G-四链体/氯化血红素DNA酶为信号分子设计了免标记的适体探针H1-S1和发夹探针H2。适体探针结合目标AFB1,在核酸外切酶I辅助下,触发靶标循环反应产生发夹H1。发夹H1与H2杂交,释放出完整的G-四链体序列,并进一步与氯化血红素结合形成G-四链体/氯化血红素DNA酶。DNA酶通过催化氧化鲁米诺-H2O2化学发光体系产生化学发光信号,实现AFB1的放大检测。在最优实验条件下,化学发光强度与AFB1质量浓度的对数在0.001~100 ng/mL范围内呈良好的线性关系,相关系数(r2)为0.9955,检出限为0.93 pg/mL,回收率为93.7%~107%。该适体传感器操作简单、灵敏度高、特异性好,在黄曲霉毒素污染检测方面具有良好的应用前景。     

地面目标雷达与红外特性数据库构建

为了对地面目标雷达与红外特性测试的各类数据进行统一规范化管理,使其高效应用,分析各类数据的特性及其处理方式,构建了目标特性数据库管理系统;数据库的整体设计中,在数据头和数据文件方案基础上增加了自动跟随数据表编号的路径生成方法,结合了接口式的运作结构,模块化的数据库功能和层次化的数据表结构设计思路;数据库的编制基于Access数据库管理软件和VC++编程软件,通过ADO数据库访问技术加以实现,详细描述了ADO接口的编程步骤,并对本接口不同指针的入库频率和提取效率进行了对比择优;在运行中,提出了主、副数据库移植性管理方法;工作实践验证了目标特性数据库管理系统的可靠性和高效性,为地面目标特性的测试与分析提供了良好的数据支撑。     

Scale-space point spread function based framework to boost infrared target detection algorithms

Small target detection is one of the major concern in the development of infrared surveillance systems. Detection algorithms based on Gaussian target modeling have attracted most attention from researchers in this field. However, the lack of accurate target modeling limits the performance of this type of infrared small target detection algorithms. In this paper, signal to clutter ratio (SCR) improvement mechanism based on the matched filter is described in detail and effect of Point Spread Function (PSF) on the intensity and spatial distribution of the target pixels is clarified comprehensively. In the following, a new parametric model for small infrared targets is developed based on the PSF of imaging system which can be considered as a matched filter. Based on this model, a new framework to boost model-based infrared target detection algorithms is presented. In order to show the performance of this new framework, the proposed model is adopted in Laplacian scale-space algorithms which is a well-known algorithm in the small infrared target detection field. Simulation results show that the proposed framework has better detection performance in comparison with the Gaussian one and improves the overall performance of IRST system. By analyzing the performance of the proposed algorithm based on this new framework in a quantitative manner, this new framework shows at least 20% improvement in the output SCR values in comparison with Laplacian of Gaussian (LoG) algorithm.     

一种改进的三帧差分运动目标实时检测算法

针对传统的三帧差分法提取的运动目标存在大量的噪声和空洞,提出了一种改进的三帧差分运动目标实时检测算法。该算法采用Surendra背景提取算法提取有效背景,对视频流中连续的三帧图像分别进行背景减除,得到的结果作为反馈对背景进行选择性更新,利用HSV颜色空间去除阴影后进行三帧差分,将差分结果进行“与”运行,通过将中间帧背景减除结果与“与”运算的结果进行“或”运算,这样可以得到运动目标的完整信息。实验结果表明,该算法能够快速、完整、准确地检测出运动目标,可有效应用于实时监控系统。