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Aye Ogan Baak Yüce‐Dursun Deka Abdullah Asl Beyler‐iil Memet Vezir Kahraman Pnar alayan Meral Birbir
zal Mutlu Nagihan Gülsoy 《先进技术聚合物》2020,31(10):2222-2228
The use of biopolymers has gained priority in tissue engineering and biotechnology, both as dressing material and for enhancing treatment efficiency. There is a demand for new biopolymers designed with protease inhibitors and antimicrobials. LL‐37 is an important antimicrobial peptide in human skin and exhibits a broad spectrum of antimicrobial activity against bacteria, fungi, and viral pathogens. Using lignin which is an abundant carbohydrate polymer in nature and a polyacrylic acid, we prepared a lignin/caprolactone biodegradable film by plastifying caprolactone and polyacyrlic acid. Lignin/caprolactone biodegradable film was activated with CDI and then immobilized LL‐37 peptide. The structure was elucidated in terms of its functional groups by attenuated total reflectance‐fourier transform infrared spectroscopy (ATR‐FTIR), and the morphology of the lignin/caprolactone biodegradable film was characterized by scanning electron microscopy (SEM) before and after the immobilization process. The amount of LL‐37 immobilized was determined by ELISA method. It was found that 97% of LL‐37 peptide was successfully immobilized onto the lignin/caprolactone biodegradable film. Antimicrobial activity was determined in the lignin/caprolactone biodegradable film samples by quantitative antimicrobial activity method. According to the results, LL‐37 immobilized lignin/caprolactone biodegradable film samples were effective on test organisms; Gram‐positive Staphylococcus aureus and Gram‐negative Escherichia coli. In bio‐compatibility assays, the ability to support tissue cell integration was detected by using 3 T3 mouse fibroblasts. Samples were examined under transverse microscope, non‐immobilized sample showed a huge cellular death, whereas LL‐37 immobilized lignin/caprolactone biodegradable film had identical cellular growth with the control group. This dual functional lignin/caprolactone biodegradable film with enhanced antibacterial properties and increased tissue cell compatibility may be used to design new materials for various types of biological applications. 相似文献
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Darpan H. Patel Prof. Dr. Dominik Marx Prof. Dr. Allan. L. L. East 《Chemphyschem》2020,21(24):2660-2666
Lignin is a potential biomass feedstock from plant material, but it is particularly difficult to economically process. Inspired by recent ball-milling results, state-of-the-art quantum mechanochemistry calculations have been performed to isolate and probe the purely mechanochemical stretching effect alone upon acid-catalyzed deconstruction of lignin. Effects upon cleavage of several exemplary simple ethers are examined first, and with low stretching force they all are predicted to cleave substantially faster, allowing for use of milder acids and lower temperatures. Effects upon an experimentally known lignin fragment model (containing the ubiquitous β-O-4 linkage) are next examined; this first required a mechanism refinement (3-step indirect cleavage, 1-step side reaction) and identification of the rate-limiting step under zero-force (thermal) conditions. Mechanochemical activation using very low stretching forces improves at first only yield, by fully shutting off the ring-closure side reaction. At only somewhat larger forces, in stark contrast, a switch in mechanism is found to occur, from 3-step indirect cleavage to the direct cleavage mechanism of simple ethers, finally strongly enhancing the cleavage rate of lignin. It is concluded that mechanochemical activation of the common β-O-4 link in lignin would improve the rate of its acidolysis via a mechanism switch past a low force threshold. Relevance to ball-milling experiments is discussed. 相似文献
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十二烷基苯磺酸钠增敏乙基紫共振光散射法测定人尿中痕量1-羟基芘 总被引:1,自引:0,他引:1
基于乙基紫(EV)与1-羟基芘(1-OHP)反应形成离子缔合物,导致体系的共振光散射(RLS)增强,建立了测定1-OHP的共振光散射法.在pH 8.0Tris-HCl缓冲介质中,最大RLS峰位于396 nm,其强度与1-OHP浓度成线性关系.加入表面活性剂十二烷基苯磺酸钠(SDBS),体系的灵敏度可提高两倍以上.方法的线性范围为4.0~982 μg·L-1,相关系数r=0.999 4,检出限1.2 μg·L-1,相对标准偏差为5.8%~7.9%,平均回收率为94%(n=6).已成功用于人尿中痕量1-OHP的测定,结果满意. 相似文献
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二氧化氯氧化云杉木质素的光谱研究 总被引:1,自引:0,他引:1
采用傅里叶变换红外光谱(FTIR)、紫外-可见光谱(UV-visible)、傅里叶变换拉曼光谱(FT-Raman)以及核磁共振(1H NMR)分析技术对云杉木质素被二氧化氯氧化前后的结构变化进行了研究。当木质素被二氧化氯氧化时,其骨架结构中的芳香环基团被有效地氧化开环。红外光谱显示木质素中的愈疮木基特征峰强度显著降低,紫丁香基苯基以及对羟基苯基特征吸收峰完全消失,在被氧化后的木质素中出现CO 共轭羰基伸缩振动特征峰。紫外光谱显示木质素在被氧化后位于280 nm处的紫外吸收显著降低。1H核磁共振波谱显示,木质素中连接在芳香环侧链的甲氧基数量被氧化后出现显著的降低,同时与苯环相连的脂肪族侧链在后也相应地减少。研究结果说明二氧化氯能有效地氧化木质素中的芳香环,并将其氧化为带有CO基因的粘康酸及其酯类物质或带有醌型基团的物质。 相似文献
56.
碱木素的近红外光谱吸收机理的研究 总被引:1,自引:1,他引:0
通过碱木素模型物对醌、邻醌和香兰素的溶液在800~900 nm的近红外光谱波段内的吸收谱图的对比发现,对醌和邻醌在此波段产生较强的吸收,而香兰素基本上没有吸收,证明了碱木素的醌型结构在800~900 nm波段内产生特征吸收。对银杏和夹竹桃磨木木素碱处理前后的溶液在800~900 nm波段内的吸光度的差别分析,发现夹竹桃的磨木木素的吸光度的相对变化更大,这是由于夹竹桃磨木木素经碱处理后产生了更多的醌型结构。这也是在硫酸盐法蒸煮过程中在800~900 nm波段内阔叶材的蒸煮液吸光度大于针叶材的蒸煮液吸光度的主要原因。 相似文献
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试验表明,铋(Ⅲ)-8-羟基喹哪啶(8-OXQ)络合物(pHll,-0.60V)的峰电流(p)具吸附特性,为准可逆电极反应过程,其电子转移数(n),传递系数(α)及饱和吸附量(Γ_ο)分别为3,0.45,6.5×10~(-12) mol/cm~2。加入十二烷基苯磺酸钠(SDBS)未形成三元络合物,因SDBS的超载强烈吸附,引起诱导吸附,电双层结构激烈变化,而使电流峰形巨变,电流峰高(i_p)增大10余倍。讨论并指出SDBS对Bi(Ⅲ)与8-羟基喹啉(8-OX)及衍生物络合吸附电流增敏或抑制,与试剂组分、结构、解离态及络合物存在状态、电荷数、符号有关。 相似文献