First synthesis of dioxadithiaporphycene with a benzene ring fused onto the double bond

Dioxadithiaporphycenes 5 and 5′ were synthesized by using the Suzuki cross-coupling and McMurry coupling reactions as the key steps. This approach provided an access to the first dioxadithiaporphycene derivative 15 with a benzene ring fused onto the double bond.     

1,2-Cyclic Monoacyl-rac-Glycerothio-phosphates of Cantharidin Analogues

Mylabris,thedriedbodyoftheChineseblisterbeetle,hasbeenusedasChinesemedicineforover2000years.Itsactiveconstituent,cantharidin,hasantitumoractivitiesandcausesleukocytosis'.Thesynthesisofcyclicglycerophospholipidcontainingcantharidinanalogueshassofarnotbeenreportedinliterature.Theconjugatesofthistypearenotonlynewprodrugsofcantharidinantitumoragentsbutalsomaygeneratetwocytotoxicgroupsagainstdifferenttargetsitesinsideaneoplasticcell'.Suchtypesofcompoundsmaybeofinterestinchemistry,biochemistryandph…     

General Information to Obtain Spherical Particles with Ordered Mesoporous Structures

Conditions for the synthesis of aluminum organophosphonate (AOP) and aluminophosphate (AlPO) spheres containing periodic mesopores were optimized and demonstrated to be general morphological controls for the surfactant‐assisted synthesis of mesoporous materials. High‐quality AOP and AlPO spheres with uniform mesopores were obtained at low and high temperatures, respectively. The aerosol‐assisted synthesis of materials with uniform mesopores was categorized by using the difference in relative density of soluble AOP and AlPO oligomers that interact with ethylene oxide (EO) units in EO_nPO_mEO_n triblock copolymer (PO=propylene oxide). Then, ordered mesoporous structures are constructed with the adequate amount of species in resultant frameworks, and the number of interactive points in soluble species determines the resultant density of the frameworks after self‐assembly. Consequently, temperature‐dependent synthesis, which allows controlled infiltration of soluble species to match the density of resultant frameworks, is required for the formation of ordered mesoporous structures under morphological control.     

1H, 13C and 15N NMR assignments for N6‐isopentenyladenosine/inosine analogues

The complete ¹H, ¹³C and ¹⁵N NMR signals assignments of some new isopentenyladenosine analogues were achieved using one‐ and two‐dimensional experiments (gs‐NOESY, gs‐HMQC and gs‐HMBC). Copyright © 2010 John Wiley & Sons, Ltd.     

2000 Vol.11 No.8 P.Preparation of AChE Inhibitors From Jujubogenin

A dammarane derivative dihydrojujubogenin-2-en-1-one, which possesses a skeleton and pharmacophore partially similar to those of Territrem B, a potent AChE inhibitor, was synthesized via three different paths. The anti-AChE activity of this compound and related analogue was measured.     

Synthesis of the active sites of molybdoenzymes: MoO2(VI) and MoO(IV)-dithiolene complexes mimicking enzymatic reactions of sulphite oxidase with saturation kinetics

[Mo^VIO₂(S₂C₂(CN)₂)₂]₂₋ (┘1) and [Mo^IVO(S₂C₂(CN)₂)₂]²⁻ (2) mimick oxidoreductase enzymatic activities of sulphite oxidase with biological electron donor, SO ₃ ²⁻ , andin vitro electron acceptor, [Fe(CN)₆]³⁻, demonstrating proton coupled electron transfer reaction in water and inhibition of the oxidation of (2) in the presence of KCN. The sulphite exidizing system is characterized by substrate saturation kinetics indicating the biological significance of the reactions     

Chemical Evolution of a Bacterial Proteome

We have changed the amino acid set of the genetic code of Escherichia coli by evolving cultures capable of growing on the synthetic noncanonical amino acid L ‐β‐(thieno[3,2‐b]pyrrolyl)alanine ([3,2]Tpa) as a sole surrogate for the canonical amino acid L ‐tryptophan (Trp). A long‐term cultivation experiment in defined synthetic media resulted in the evolution of cells capable of surviving Trp→[3,2]Tpa substitutions in their proteomes in response to the 20 899 TGG codons of the E. coli W3110 genome. These evolved bacteria with new‐to‐nature amino acid composition showed robust growth in the complete absence of Trp. Our experimental results illustrate an approach for the evolution of synthetic cells with alternative biochemical building blocks.