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71.
Using HPLC we purified an antibacterial peptide named CM_2Ph_1 from the hemolymph ofpupae of silkworm (Bombyx mori) immunized with polyI:C. Amino acid composition analysisshowed that CM_2Ph_1 contained 16 kinds of amino acids. Its primary structure determined bythe automatic Edman degradation method is GNFFKDLEKMGQRVRDAVISAAPAVDTLAKA-KALGQ. Its C-terminal residue was assumed to be Gln with a blocking α-carboxylamide bycarboxypeptidases analysis. The purified CM_2Ph_1 was found to have inhibition effects invarying degrees on several bacterial strains. At a concentration of 0.35 μmol/L, CM_2Ph_1could inhibit the growth of 50% E. coli D31 strain. Some other antibacterial peptides were compared with CM_2Ph_1 in respect to their struc-tures and functions. Their homology was also discussed in this paper. 相似文献
72.
应用烯基铜锂试剂合成消旋日本丽金龟性信息素徐章煌,黄锦霞,李焰,潘贻罕,蒋济隆,赵建洪(湖北大学化学系武汉430062)(华中理工大学固态电子学系武汉)关键词日本丽金龟,性信息素,烯基铜日本丽金龟成虫对多种树木、观赏植物及农作物危害极大,1976年,... 相似文献
73.
Chen T Yang J Wang Y Zhan C Zang Y Qin J 《Journal of computer-aided molecular design》2005,19(5):319-328
Summary Stem cell factor (SCF) and macrophage colony stimulating factor (M-CSF) can act in synergistic way to promote the growth of
mononuclear phagocytes. SCF–M-CSF fusion proteins were designed on the computer using the Homology and Biopolymer modules
of the software packages InsightII. Several existing crystal structures were used as templates to generate models of the complexes
of receptor with fusion protein. The structure rationality of the fusion protein incorporated a series of flexible linker
peptide was analyzed on InsightII system. Then, a suitable peptide GGGGSGGGGSGG was chosen for the fusion protein. Two recombinant
SCF–M-CSF fusion proteins were generated by construction of a plasmid in which the coding regions of human SCF (1–165aa) and
M-CSF (1–149aa) cDNA were connected by this linker peptide coding sequence followed by subsequent expression in insect cell.
The results of Western blot and activity analysis showed that these two recombinant fusion proteins existed as a dimer with
a molecular weight of ~84 KD under non-reducing conditions and a monomer of ~42 KD at reducing condition. The results of cell
proliferation assays showed that each fusion protein induced a dose-dependent proliferative response. At equimolar concentration,
SCF/M-CSF was about 20 times more potent than the standard monomeric SCF in stimulating TF-1 cell line growth, while M-CSF/SCF
was 10 times of monomeric SCF. No activity difference of M-CSF/SCF or SCF/M-CSF to M-CSF (at same molar) was found in stimulating
the HL-60 cell linear growth. The synergistic effect of SCF and M-CSF moieties in the fusion proteins was demonstrated by
the result of clonogenic assay performed with human bone mononuclear, in which both SCF/M-CSF and M-CSF/SCF induced much higher
number of CFU-M than equimolar amount of SCF or M-CSF or that of two cytokines mixture. 相似文献
74.
Rafael Augusto Soldi Daiane Szczerbowski Paulo Henrique Gorgatti Zarbin 《Tetrahedron》2018,74(1):88-95
In a previous study we reported the identification of the first ketone found in the Pentatomidae family, the sex attractant pheromone of the male stink bug Pallantia macunaima, (6R,10S)-6,10,13-trimethyltetradecan-2-one. Here we describe an efficient enantioselective route for the synthesis of the four stereoisomers of this pheromone. The synthesis was conceived as the connection of two chiral building blocks, employing (R)- or (S)-citronellol and methyl (S)-3-hydroxy-2-methylpropionate as the source of chirality. 相似文献
75.
The stereospecific synthesis of all four isomeric 6,8-heneicosadien-11-ones, sex pheromone components of the painted apple moth, Teia anartoides, is reported using the Suzuki-coupling of vinyl boronic acid and vinyl iodide intermediates. 相似文献
76.
Bhaskar Dhotare 《Tetrahedron letters》2005,46(37):6219-6221
(R)-2,3-Cyclohexylideneglyceraldehyde 1 has been used to prepare functionalized δ-lactones. This was exemplified by a simple and efficient synthesis of the oviposition pheromone 10 of Culex pipens fatigans. 相似文献
77.
手性烯醇硅醚——薄荷烷氧基二甲硅烷基环戊用烯醇硅醚与十一醛进行立体选择性亲电取代反应,得到赤式占优势的2-(1-羟基十一烷基)环戊酮,分离纯化后经Bacyer-Villiger重排和乙酰化,得到淡色库蚊产卵引诱信息素——赤式6-乙酰氧基十六碳烷酸-5-内酯。其中活性组分(-)-(5R,6S)异构体占50%,较一般非立体选择性合成法提高25%。 相似文献
78.
Rosemary J. Armstrong-Chong 《Tetrahedron》2004,60(45):10239-10244
Sequential treatment of ω-bromoalkyl triflates with an alkynyllithium at 0 °C followed by addition of a second alkynyllithium and NaI and heating the reaction mixture provides a simple one-pot access to unsymmetrical diynes in good yields. These diynes may be transformed stereoselectively into diene pheromones such as (Z,Z)- and (E,Z)-3,13-octadecadienyl acetate. 相似文献
79.
5α-雄甾-16-烯-3β-对甲苯磺酸酯的溶剂解反应 总被引:1,自引:0,他引:1
5α-雄甾-16-烯-3β-对-甲苯磺酸酯(1a)和亚硝酸钠在二甲基甲酰胺(DMF)中加热反应,可生成5α-雄甾-16-烯-3α-醇(2a)及其甲酸酯(2b)和5α-雄甾-16-烯-3-酮(3)等产物。由于 DMF 参与了反应,所以推测这是一种溶剂解反应,并对反应机理进行了讨论。 相似文献
80.
本文报道有机鉮盐和各种不同的醛在固-液相转移条件下,以碳酸钾为碱,简便合成共轭不饱和醛、共轭不饱和酮以及共轭不饱和酰胺。其反应通式如下:(?)n=O,1;m=0,1 and(?)X=CHO,COCH_3,CONR~1R_2当m=0时,产物几乎全部是2E 或2E,4E 产物,当m=1时,2E,4E 或2E,4E,6E 产物为主,Z 构型产物在催化量碘作用下易异构化成 E 构型产物。以此合成方法,还合成了一些具有生物活性的天然产物。该合成方法操作简便,反应条件温和,产物高度立体选择性,产率优良,这为多烯醛,多烯酮,多烯酰胺以及有关天然产物的合成提供了实用途径。 相似文献