汽车产业模块化对不连续创新影响的实证分析

为探讨产业模块化与不连续创新之间的相互作用关系,分别构建了产业模块化指数与不连续创新指数的测度指标,基于全球汽车产业1972~2011年的专利数据,主要利用格兰杰因果检验方法就产业模块化对不连续创新的影响及其因果方向进行了实证分析。结果表明,产业模块化对不连续创新存在显著正向影响且长期影响较为显著。     

区域创新系统协同演化机制与优化设计研究

为揭示区域创新系统协同演化机制的本质与规律,在对区域创新系统自组织特征予以描述的基础上,构建区域创新系统协同演化的哈肯模型,选用基础共性技术创新数据与制度创新数据进行实证研究,运用Minitab软件设计系统演化方案并提出优化对策。研究结果表明:基础共性技术创新代表量是区域创新系统动态演化的序参量;基础共性技术创新与制度创新在区域创新系统演化过程中具有协同效应,但协同度欠佳;制度创新递增的正反馈机制在区域创新系统演化过程中的信噪比最大,基础共性技术创新对制度创新推动作用的反映最灵敏;当信噪比最大的参数λ₂<0,形成制度创新递增的正反馈机制,同时调控参数使得a、b、λ₁均小于0且尽量保持a的绝对值最大,区域创新系统将会实现最优演化水平。     

Bayesian estimation of incompletely observed diffusions

We present a general framework for Bayesian estimation of incompletely observed multivariate diffusion processes. Observations are assumed to be discrete in time, noisy and incomplete. We assume the drift and diffusion coefficient depend on an unknown parameter. A data-augmentation algorithm for drawing from the posterior distribution is presented which is based on simulating diffusion bridges conditional on a noisy incomplete observation at an intermediate time. The dynamics of such filtered bridges are derived and it is shown how these can be simulated using a generalised version of the guided proposals introduced in Schauer, Van der Meulen and Van Zanten (2017, Bernoulli 23(4A)).     

基于卓越工程师培养目标下的大学物理实验创新培养模式

针对卓越工程师的基本训练要求及社会发展的需要,以“卓越工程师”培养目标为导向,以辅助教学系统、实验数据处理系统和学生创新实践平台三大模块为依托,根据学生学习的不同阶段和知识积累过程,建立全方位、模块化、逐层深入的实验教学培养模式,把大学物理实验室建设成培养学生创新能力的重要基地.     

Integral representation with respect to stopped continuous local martingales

We consider a Markovian jump process θ, with finite state space, feeding the parameters of a nonlinear diffusion process X. We observe θ and X in white noise, and—given a function f—we want to construct a finite filter for the f(X _t )-process. An algorithm is investigated which will produce a finite filter if it halts after a finite number of steps, and we give necessary and. sufficient conditions for this to happen.     

The bit‐economy: An artificial model of open‐ended technology discovery

We describe and demonstrate an artificial model of technology discovery called the Bit‐Economy. The model is built from a minimal set of fundamental hallmarks of technology and develops under an open‐ended evolutionary operator which rewards new technology which is able to coordinate both spatially and temporally with the existing technology set. The Bit‐Economy, is able to replicate several features of real technology development including nonmonotonic growth, bunching of creation and destruction events, qualitative topologies of patent networks, and efficiency and waste‐management gains. In contrast to related works, we do not apply an exogenous fitness landscape and so are able to study the process of technology discovery as a self‐guided search toward more complex outcomes. © 2013 Wiley Periodicals, Inc. Complexity 18: 57–67, 2013     

“对比实验+现象驱动的知识挖掘”在高分子材料合成创新实验教学中的尝试与运用

高分子材料合成实验是高分子专业的核心实验课程之一,如何建立实验课程与理论课程的有效衔接,加深学生对所学知识点的深入理解和活学活用,是本课程的主要目标。为此,笔者和教学团队提出：在同一个实验中改变某个实验变量,在教学班中引入对比实验,通过这些改变引起的不同实验现象和由此产生的材料性能的迥然差异,引导学生从现象出发,联系理论课堂知识进行深入分析。这种尝试有效改变了以往实验教学中所有教学班千篇一律的操作和几乎完全相同的实验现象与结果,有效激发了学生的主动性,提高了其分析问题、解决问题的能力。2年的实验教学反馈表明,“对比实验的引入”和“现象驱动的知识挖掘”帮助学生有效巩固了理论课堂的知识点,做到了活学活用。     

New Opportunities for the Utilization of the Sulfoximine Group in Medicinal Chemistry from the Drug Designer's Perspective**

Extension of the medicinal chemistry toolbox is in the vital interest of drug designers. However, the diffusion of an innovation can be a lengthy process. Along these lines, it took almost 70 years before the use of the sulfoximine group reached a critical mass in medicinal chemistry. Even though interest in this versatile functional group has increased exponentially in recent years, there is ample room for further innovative applications. This Review highlights emerging trends and opportunities for drug designers for the utilization of the sulfoximine group in medicinal chemistry, such as in the construction of complex molecules, proteolysis targeting chimeras (PROTACs), antibody-drug conjugates (ADCs) and novel warheads for covalent inhibition.     

“焰色反应”实验的创新设计

针对教材中“焰色反应”实验存在的不足,通过对“焰色反应”原理及条件的分析,进行了4大实验创新设计,获得异彩纷呈的实验现象,充分激发了学生的学习积极性,培养对化学的热爱。本课的创新改进实现了对教材内容的二次开发,充分发掘了化学实验的教育功能,让课堂焕发活力。     

不同版本高中化学教科书中学生必做实验的分析与启示——基于“科学探究与创新意识”素养

以人教版、苏教版、鲁科版(2019年版)和沪科版(2020年版)高中化学教科书中的学生必做实验文本为研究对象,基于“科学探究与创新意识”素养构建高中化学教科书中学生必做实验文本的分析框架,分析和比较4个版本教科书中学生必做实验文本“科学探究与创新意识”素养的体现及其异同,为学生必做实验教学提供启示和建议。