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151.
In this paper, we consider a stochastic control problem on a finite time horizon. The unit price of capital obeys a logarithmic Brownian motion, and the income from production is also subject to the random Brownian fluctuations. The goal is to choose optimal investment and consumption policies to maximize the finite horizon expected discounted hyperbolic absolute risk aversion utility of consumption. A dynamic programming principle is used to derive a time‐dependent Hamilton–Jacobi–Bellman equation. The Leray–Schauder fixed point theorem is used to obtain existence of solution of the HJB equation. At last, we derive the optimal investment and consumption policies by the verification theorem. The main contribution in this paper is the use of PDE technique to the finite time problem for obtaining optimal polices. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
152.
Electroless Ni–P and Ni–P–TiCN composite coatings have been deposited successfully on Al substrates. Scanning electron microscopy (SEM) and energy dispersive X‐ray (EDX) techniques were applied to study the surface morphology and the chemical composition of the deposited films. Moreover, X‐ray diffraction (XRD) proved that Ni–P and Ni–P–TiCN deposits have amorphous structures. The properties of Ni–P–TiCN/Al composite films such as hardness, corrosion resistance and electrocatalytic activity were examined and compared with that of Ni–P/Al film. The results of hardness measurements reveal that the presence of TiCN particles with Ni–P matrix improves its hardness. Additionally, the performance against corrosion was examined using Tafel lines and electrochemical impedance spectroscopy techniques in both of 0.6 M NaCl and a mixture of 0.5 M H2SO4 with 2 ppm HF solutions. The results indicate that the incorporation of high dispersed TiCN particles into Ni–P matrix led to a positive shift of the corrosion potential and an increase in the corrosion resistance for all aluminum substrates after their coating with Ni–P–TiCN. In addition, Ni–P–TiCN/Al electrodes showed a higher electrochemical catalytic activity and stability toward methanol oxidation in 0.5 M NaOH solution compared with that of Ni–P/Al. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
153.
Application of plug–plug technique to ACE experiments for discovery of peptides binding to a larger target protein: A model study of calmodulin‐binding fragments selected from a digested mixture of reduced BSA
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Kazuki Saito Mamiko Nakato Takaaki Mizuguchi Shinji Wada Hiromasa Uchimura Hiroshi Kataoka Shigeyuki Yokoyama Hiroshi Hirota Yoshiaki Kiso 《Electrophoresis》2014,35(6):846-854
To discover peptide ligands that bind to a target protein with a higher molecular mass, a concise screening methodology has been established, by applying a “plug–plug” technique to ACE experiments. Exploratory experiments using three mixed peptides, mastoparan‐X, β‐endorphin, and oxytocin, as candidates for calmodulin‐binding ligands, revealed that the technique not only reduces the consumption of the protein sample, but also increases the flexibility of the experimental conditions, by allowing the use of MS detection in the ACE experiments. With the plug–plug technique, the ACE–MS screening methodology successfully selected calmodulin‐binding peptides from a random library with diverse constituents, such as protease digests of BSA. Three peptides with Kd values between 8–147 μM for calmodulin were obtained from a Glu‐C endoprotease digest of reduced BSA, although the digest showed more than 70 peaks in its ACE–MS electropherogram. The method established here will be quite useful for the screening of peptide ligands, which have only low affinities due to their flexible chain structures but could potentially provide primary information for designing inhibitors against the target protein. 相似文献
154.
Acceleration of self‐consistent field convergence in ab initio molecular dynamics simulation with multiconfigurational wave function
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The Lagrange interpolation of molecular orbital (LIMO) method, which reduces the number of self‐consistent field iterations in ab initio molecular dynamics simulations with the Hartree–Fock method and the Kohn–Sham density functional theories, is extended to the theory of multiconfigurational wave functions. We examine two types of treatments for the active orbitals that are partially occupied. The first treatment, as denoted by LIMO(C), is a simple application of the conventional LIMO method to the union of the inactive core and the active orbitals. The second, as denoted by LIMO(S), separately treats the inactive core and the active orbitals. Numerical tests to compare the two treatments clarify that LIMO(S) is superior to LIMO(C). Further applications of LIMO(S) to various systems demonstrate its effectiveness and robustness. © 2014 Wiley Periodicals, Inc. 相似文献
155.
Identification and analysis of alkaloids in cortex Phellodendron amurense by high‐performance liquid chromatography with electrospray ionization mass spectrometry coupled with photodiode array detection
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Xiaoyan Xian Bohang Sun Xueting Ye Guanying Zhang Pengyi Hou Huiyuan Gao 《Journal of separation science》2014,37(13):1533-1545
Alkaloids from Cortex Phellodendron amurense Rupr. were identified to determine the material basis for the bioactivity of this herb. HPLC–ESI‐MS with photodiode array detection coupled to XCharge C18 column was applied to analyze the alkaloids qualitatively and quantitatively. A total of 37 alkaloids were identified and tentatively characterized from the ethanol extract by online ESI‐MSn fragmentation and UV spectral analysis. A total of ten alkaloids, including four novel natural products, were tentatively identified for the first time in P. amurense. The fragmentation pathways for certain compounds were analyzed. The contents of a pair of isomers (columbamine and jatrorrhizine) and four main alkaloids (phellodendrine, magnoflorine, berberine, and palmatine) were simultaneously quantified using the aforementioned method. Results showed that the newly discovered and known components of P. amurense were helpful in determining the material basis for the bioactivity of the herb. The application of the XCharge C18 column is a suitable and practical method for the isolation of alkaloids in plants. 相似文献
156.
《Comptes Rendus Chimie》2014,17(7-8):775-784
Four types of SBA-15 were prepared with different times and temperatures of treatment in order to obtain a range of micropore sizes. CO oxidation was used as a probe reaction in order to evaluate the nature of the active species when SBA-15s were doped with ca 10% Ag deposited from an AgNO3 solution and calcined or reduced at 350 °C. The texture (TEM, nitrogen physisorption), structure (XRD) and reducibility (TPR) of the various catalysts (Ag/SBA-15) were studied and compared to those of a catalyst prepared by deposition of silver on fumed silica as a reference. These catalysts differ initially by the nature of silica and by pore sizes. In CO oxidation, pre-reduced catalysts are more active than pre-oxidised ones. This has to do with two phenomena, i.e. sintering, which produces large inactive silver particles, and formation of active silver species in the form of small Ag2O particles. 相似文献
157.
158.
Revathy Deivasigamani Nur Shahira Abdul Nasir Mohd Ambri Mohamed Muhamad Ramdzan Buyong 《Electrophoresis》2022,43(4):609-620
This article describes a dielectrophoresis (DEP)-based simulation and experimental study of human epidermal keratinocyte (HEK) cells for wounded skin cell migration toward rapid epithelialization. MyDEP is a standalone software designed specifically to study dielectric particles and cell response to an alternating current (AC) electric field. This method demonstrated that negative dielectrophoresis (NDEP) occurs in HEK cells at a wide frequency range in highly conductive medium. The finite element method was used to characterize particle trajectory based on DEP and drag force. The performance of the system was assessed using HEK cells in a highly conductive EpiLife suspending medium. The DEP experiment was performed by applying sinusoidal wave AC potential at the peak-to-peak voltage of 10 V in a tapered aluminum microelectrode array from 100 kHz to 1 MHz. We experimentally observed the occurrence of NDEP, which attracted HEK cells toward the local electric field minima in the region of interest. The DIPP-MotionV software was used to track cell migration in the prerecorded video via an automatic marker and estimate the average speed and acceleration of the cells. The results showed that HEK cell migration was accomplished approximately at 6.43 μm/s at 100 kHz with 10 V, and FDEP caused the cells to migrate and align at the target position, which resulted in faster wound closures because of the application of an electric field frequency to HEK cells in random locations. 相似文献
159.
Single crystals of a new calcium(II) complex of benzilic acid, [Ca(C14H11O3)2(C14H12O3)2] have been successfully grown by gel diffusion technique at room temperature. Single crystal X-ray diffraction study reveals that the compound belongs to orthorhombic system with space group Fddd. The adjacent CaO8 units are linked via O–H–O interaction to form one dimensional polymeric chains. The extensive hydrogen bonding interactions lead to a supramolecular structure. The grown crystals were further characterized by elemental analysis, FT-IR, UV–Visible, thermogravimetric, powder X-ray diffraction and solid state photoluminescence studies. 相似文献
160.
本研究探讨了超声内镜联合CT门静脉成像技术对肝硬化食管胃静脉曲张(GOV)程度及治疗效果的评价价值。选取72例肝硬化GOV患者为研究对象,根据食管静脉曲张套扎术(EVL)治疗效果分为良好组与不良组。结果发现,不良组总横断面表面积、胃左静脉、门静脉、脾静脉、肠系膜上静脉直径及门静脉长度均大于良好组,曲张静脉壁厚度小于良好组(P<0.05);总横断面表面积、胃左静脉、门静脉、脾静脉、肠系膜上静脉直径及门静脉长度与肝功能Child-Pugh分级、静脉曲张程度呈正相关,曲张静脉壁厚度与肝功能Child-Pugh分级、静脉曲张程度呈负相关(P<0.05);总横断面表面积、曲张静脉壁厚度/胃左静脉、门静脉、脾静脉、肠系膜上静脉直径及门静脉长度均为肝硬化GOV患者治疗效果的影响因素(P<0.05);超声内镜、CT门静脉成像参数联合预测肝硬化GOV患者治疗效果的AUC为0.857。可见,超声内镜、CT门静脉成像参数与肝硬化GOV程度、肝功能分级及EVL治疗效果密切相关,可为临床预测EVL治疗效果提供一定参考。 相似文献