Metformin and glitazones: does similarity in biomolecular mechanism originate from tautomerism in these drugs?

This theoretical study attempts to find out similarity between metformin and glitazone class of antidiabetic drugs. It was found that some tautomeric forms of both metformin and thiazolidinedione ring of glitazones have similar molecular electrostatic potential (MESP) surface and may bind to a common complementary surface. Complexation and docking studies were also carried out in order to support this hypothesis. Copyright © 2007 John Wiley & Sons, Ltd.     

在“画法几何及机械制图”课程教学中如何培养学生的能力

本文从高等教育必须加强学生各种能力培养的观点出发，阐述了在“画法几何及机械制图”课程教学活动中如何培养大学生的自学能力、空间想象能力、逻辑思维能力、读图和绘图能力的途径和方法上所作的探索和体会。     

A Hochschild Homology Euler Characteristic for Circle Actions

We define an S¹-Euler characteristic, _S ¹(X), of a circle action on a compact manifold or finite complex X. It lies in the first Hochschild homology group HH ₁(G) where G is the fundamental group of X. This _S ¹(X) is analogous in many ways to the ordinary Euler characteristic. One application is an intuitively satisfying formula for the Euler class (integer coefficients) of the normal bundle to a smooth circle action without fixed points on a manifold. In the special case of a three-dimensional Seifert fibered space, this formula is particularly effective.     

On the Classification of Flag-Transitive c.c*- Geometries

Let ( G) be a flag-transitive c.c*-geometry whose point-stabilizer is not an affine group. We list all known examples and show that, if (, G) is a minimal unknown example, then G is an almost simple group and the commutator subgroup G is a simple group of Lie type.     

让世界跳跃的人--马克思*普朗克

回顾了普朗克在物理学上的贡献和对爱因斯坦的帮助，挖掘了他的物理思想，得到对他公正的认识．     

An experiment on program development

As a contribution to programming methodology, the paper contains a detailed, step-by-step account of the considerations leading to a program for solving the 8-queens problem. The experience is related to the method of stepwise refinement and to general problem solving techniques.     

Analysis of the Effects of Protic,Aprotic, and Multi-Component Solvents on the Fluorescence Emission of Naphthalene and its Exciplex with Triethylamine

The emission spectra of naphthalene (NP)–triethylamine (TEA) systems were measured under steady-state illumination conditions in some protic and aprotic solvent-tetrahydrofuran (THF) mixtures. The fluorescence spectrum of the NP–TEA system in THF could be separated into two component bands (band A at 329 nm (fluorescence of NP) and band B at 468 nm (emission from an intermolecular exciplex)). The intensities of bands A and B decreased with increasing solvent polarity. The intensity of band B also decreased owing to the hydrogen-bonding interaction between TEA and protic solvents, but in this case the intensity of band A increased. The decrease in the intensity of band A with increasing solvent polarity is considered to be caused by the enhanced formation of an ion-pair parallel to the formation of an exciplex with increasing solvent polarity. The decrease in the intensity of band B is considered to be caused by the enhanced formation of ion-pair both parallel to and through the formation of the exciplex. The increase in the intensity of band A and the decrease in that of band B upon the addition of protic solvents is caused by the decrease in the concentration of free TEA. Acetonitrile only has a polar effect and trichloroacetic acid only has a hydrogen-bonding (protonation) effect, while alcohols have both the effects.     

Algebraic -actions of entropy rank one

We investigate algebraic -actions of entropy rank one, namely those for which each element has finite entropy. Such actions can be completely described in terms of diagonal actions on products of local fields using standard adelic machinery. This leads to numerous alternative characterizations of entropy rank one, both geometric and algebraic. We then compute the measure entropy of a class of skew products, where the fiber maps are elements from an algebraic -action of entropy rank one. This leads, via the relative variational principle, to a formula for the topological entropy of continuous skew products as the maximum of a finite number of topological pressures. We use this to settle a conjecture concerning the relational entropy of commuting toral automorphisms.

     

Poincaré duality in P.A. Smith theory

Let , or more generally be a finite -group, where is an odd prime. If acts on a space whose cohomology ring fulfills Poincaré duality (with appropriate coefficients ), we prove a mod congruence between the total Betti number of and a number which depends only on the -module structure of . This improves the well known mod congruences that hold for actions on general spaces.