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21.
Toyo'oka T 《Biomedical chromatography : BMC》2008,22(9):919-930
This review summarizes the determination methods for histamine and the metabolites in biological specimens by separation techniques, such as gas chromatography, liquid chromatography and capillary electrophoresis. The typical applications using these methods are also described in this review together with the characteristics of the methods. Copyright (c) 2008 John Wiley & Sons, Ltd. 相似文献
22.
Dorota aewska Paula Zarba Justyna Gody Agata Doroz-Ponka Annika Frank David Reiner-Link Marek Bajda Dorota Stary Szczepan Mogilski Agnieszka Olejarz-Maciej Maria Kaleta Holger Stark Barbara Malawska Katarzyna Kie-Kononowicz 《Molecules (Basel, Switzerland)》2021,26(12)
Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but interconnected targets can contribute to a desired pharmacological effect in these complex illnesses. Histamine H3 receptors (H3Rs) play an important role in the brain, influencing the release of important neurotransmitters, such as acetylcholine. Compounds blocking their activity can increase the level of these neurotransmitters. Cholinesterases (acetyl- and butyrylcholinesterase) are responsible for the hydrolysis of acetylcholine and inactivation of the neurotransmitter. Increased activity of these enzymes, especially butyrylcholinesterase (BuChE), is observed in neurodegenerative diseases. Currently, cholinesterase inhibitors: donepezil, rivastigmine and galantamine are used in the symptomatic treatment of AD. Thus, compounds simultaneously blocking H3R and inhibiting cholinesterases could be a promising treatment for AD. Herein, we describe the BuChE inhibitory activity of H3R ligands. Most of these compounds show high affinity for human H3R (Ki < 150 nM) and submicromolar inhibition of BuChE (IC50 < 1 µM). Among all the tested compounds, 19 (E153, 1-(5-([1,1′-biphenyl]-4-yloxy)pentyl)azepane) exhibited the most promising in vitro affinity for human H3R, with a Ki value of 33.9 nM, and for equine serum BuChE, with an IC50 of 590 nM. Moreover, 19 (E153) showed inhibitory activity towards human MAO B with an IC50 of 243 nM. Furthermore, in vivo studies using the Passive Avoidance Task showed that compound 19 (E153) effectively alleviated memory deficits caused by scopolamine. Taken together, these findings suggest that compound 19 can be a lead structure for developing new anti-AD agents. 相似文献
23.
Regine Gries Prof. Robert Britton Michael Holmes Huimin Zhai Jason Draper Prof. Gerhard Gries 《Angewandte Chemie (International ed. in English)》2015,54(4):1135-1138
Bed bugs have become a global epidemic and current detection tools are poorly suited for routine surveillance. Despite intense research on bed bug aggregation behavior and the aggregation pheromone, which could be used as a chemical lure, the complete composition of this pheromone has thus far proven elusive. Here, we report that the bed bug aggregation pheromone comprises five volatile components (dimethyl disulfide, dimethyl trisulfide, (E)‐2‐hexenal, (E)‐2‐octenal, 2‐hexanone), which attract bed bugs to safe shelters, and one less‐volatile component (histamine), which causes their arrestment upon contact. In infested premises, a blend of all six components is highly effective at luring bed bugs into traps. The trapping of juvenile and adult bed bugs, with or without recent blood meals, provides strong evidence that this unique pheromone bait could become an effective and inexpensive tool for bed bug detection and potentially their control. 相似文献
24.
《Analytical letters》2012,45(4):619-639
Abstract Some original histamine membrane sensors were prepared by incorporating thiopyrilium (TP) derivative as an excellent charged carrier. Among these sensors, TP2 shows the best response to histamine in a wide concentration range from 2.5×10?6 to 1.0×10?1 mol L?1 with a slope of 55.6±0.7 mV decade?1 and with a detection limit of 1.0 µmol L?1 (~0.1 ppm). The interference between histamine and several amino acids and common inorganic anions was negligible as shown by the potentiometric selectivity coefficient data. The prepared electrode was used for the determination of histamine in a human serum synthetic sample. Theoretical calculations were carried out to find the best interactions between histamine and different ligands. 相似文献
25.
Screening of allergic components mediated by H1R in homoharringtonine injection through H1R/CMC‐HPLC/MS 下载免费PDF全文
Ying Guo Shengli Han Jingjing Cao Qi Liu Tao Zhang 《Biomedical chromatography : BMC》2014,28(12):1607-1614
It has been reported that the histamine H1 receptor (H1R) gene is up‐regulated in patients with allergic rhinitis and H1R expression level strongly correlates with the severity of allergy symptoms. Drugs for therapy should avoid allergy symptoms, especially for patients with over‐expressed H1R. Therefore, screening of the components which could induce H1R activation is urgently needed for drug safety evaluation. Homoharringtonine injection is a preparation for acute nonlymphocytic leukemia, which is approved by China Food and Drug Administration (CFDA) and US Food and Drug Administration. However, severely adverse reactions often occur with intravenous injection of the preparation. In present study, an H1R/CMC model was applied for capturing membrane retained components which could induce H1R activation. Retention components were enriched and analyzed by H1R/CMC‐HPLC/MS. Homoharringtonine was recognized, separated and identified in homoharringtonine injection. Ca2+ flux assay and p‐IP3R expression founded that homoharringtonine retained by the H1R/CMC model increased phosphorylation of IP3R and promoted cytosolic free Ca2+ elevation in a dose‐dependent manner which further verified the activity of homoharringtonine in activating the H1R. In conclusion, homoharringtonine was screened and identified as a potential allergic factor. This provides an indication that a patient with over‐expressed H1R should be aware of possible allergic reaction when applying homoharringtonine injection. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
26.
Qian Feng WENG Fang Quan XIA Wen Rui JIN* School of Chemistry Chemical Engineering Shandong University Jinan 《中国化学快报》2002,13(10)
Histamine is one of the chemical mediators in connection with allergies. Only Pihel et al.1 reported a method for detection of histamine in isolated mast cells by high- performance liquid chromatography with electrochemical detection. In this method, single cells were removed and transferred to 300-nL microvials. A part of the supernatant from individual vials was injected into the chromatography column. The analysis of histamine in individual rat peritoneal mast cells using CZE with amp… 相似文献
27.
Fexofenadine is a selective H1-histamine receptor antagonist, which is an attractive alternative treatment for allergy symptoms. An efficient and environmentally friendly synthetic approach for the preparation of fexofenadine was developed from commercially available cumene. The method involves the Friedel–Craft's reaction, substitution, reduction, bromination, and the Grignard reaction.
28.
Qian-Ni Guo Zao-Ying Li Kai-Chung Lau Maxwell J. Crossley 《Supramolecular chemistry》2013,25(2):122-129
Adopting the rarely used β-functionalisation strategy in porphyrin-based sensor design, an amine receptive site is appended onto the zinc(II) porphyrin molecular framework affording a ditopic chemosensor 4. The assembled chemosensor interacts selectively with histamine in toluene via a ‘two-site’ binding mode. Association constant of the complex evaluated from the respective UV–vis spectra is found to be (2.32 ± 0.57) × 106, which is approximately 4-fold greater than those complexes derived from 4 and nicotine/histidine. On the basis of a combined spectroscopic method and molecular modelling, the binding model of the porphyrin host and biogenic guest molecules is established. Our results clearly demonstrate the viability of the design and development of the porphyrin-based chemosensor by appending a receptor at the β-pyrrolic carbon of the porphyrin scaffold. 相似文献
29.
建立了液相色谱-串联质谱(LC-MS/MS)检测P815细胞脱颗粒后上清液中组胺含量的方法。采用C18柱(4.6 mm×100 mm,3.5μm)进行分离,以体积比为60∶40的乙腈-0.5 mmol/L乙酸铵溶液(含0.3%甲酸)为流动相,流速0.4 mL/min;在电喷雾正离子化模式下,采用多离子反应检测方式(MRM)进行检测;检测离子对为m/z 112>95、112>68。在优化条件下,样品可在6 min内完成分析,细胞液中组胺在4.0~128.0μg/L范围内线性关系良好(r2=0.997 9)。定量下限(S/N>10)为1.2μg/L,检出限(S/N=3)为0.3μg/L。在加标水平为16、64、128μg/L时,细胞上清液中组胺的平均回收率为90%~94%,相对标准偏差(n=6)为4.1%~5.9%。该方法简便、灵敏、重复性好,可用于中药注射剂对P815细胞脱颗粒后上清液中组胺含量的测定。 相似文献
30.
Ana-Maria Iordache Rodica Cristescu Eugenia Fagadar-Cosma Andrei C. Popescu Anton A. Ciucu Stefan M. Iordache Adriana Balan Cornelia Nichita Ioan Stamatin Douglas B. Chrisey 《Comptes Rendus Chimie》2018,21(3-4):270-276
This study reports on deposition of asymmetrical substituted meso-phenyl porphyrin, 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin (CPTPP) thin films by matrix-assisted pulsed laser evaporation (MAPLE) on screen-printed electrodes, aiming for histamine detection. Raman spectrometry confirmed that CPTPP chemical structure was preserved in MAPLE-deposited thin films at 200 mJ/cm2 laser fluence. Atomic force microscopy topography revealed that MAPLE-deposited thin films have a better coverage on the working electrode made of carbon compared to the ones obtained by dropcasting. Cyclic voltammetry demonstrated that CPTPP is an appropriate mediator for histamine detection in trichloroacetic acid solution. We proved that MAPLE serves as a soft technique in fabrication of porphyrin thin films and patterns. 相似文献