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Marco Cespi Luca Casettari Giulia Bonacucina Gianfabio Giorgioni Diego R Perinelli Giovanni Filippo Palmieri 《先进技术聚合物》2013,24(11):1018-1024
This paper deals with a new application of diblock methoxy polyethylene glycol‐polylactide block copolymers, a class of synthetic biomaterials largely studied in the pharmaceutical and biomedical fields owing to their favorable properties such as biocompatibility, biodegradability, low immunogenicity, and good mechanical properties. In this work, these materials were evaluated as additives for gastro‐soluble pharmaceutical coating aimed to reduce film stiffness and water permeability. Two copolymers with different polylactide chain lengths were synthesized and characterized in term of molecular weight and solid‐state properties. A series of free films with different hypromellose/copolymers ratio were prepared and characterized in terms of appearance, components miscibility, plasticity, and water vapor permeability. The obtained results demonstrate that copolymers effectively influence hypromellose film properties according to their concentration and molecular weight. Specifically, the addition of the copolymer with a molecular weight of 6.5 kDa in a ratio hypromellose:polymer 5:1, allowed to obtain films with good appearance, improved plasticization, and water permeability properties. For higher molecular weight, copolymer or different ratios was not possible to observe the improvement of all the properties at the same time. The results also make possible to define the critical features to improve in order to use block copolymers as additive in hypromellose film coating. The availability of new water‐soluble additives able to work as plasticizer and moisture sealer in polymeric films represents an important progress not only in the field of pharmaceutical coating but also in that of food coatings, as for example in the formulation of edible films. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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Sodium alginate (SA) was blended with varying amounts of poly(ethylene glycol) (PEG) viz., 10, 20, 30, 40 and 50 wt % by using water as a solvent. The obtained SA/PEG blends have been characterized for thermal behavior by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) and surface morphology by scanning electron microscopic (SEM) methods. DSC analysis indicates the increase in glass transition temperature (Tg) of the blends with an increase in PEG content in the blend, which is due to chain entanglement. TGA results reveal the enhancement of thermal stability of SA/PEG blends in terms of the onset of degradation and percentage of weight loss. SEM photomicrographs shows the two phase morphology. This result indicates the immiscible nature of the SA/PEG blends. 相似文献
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Meet Kamal 《高分子科学杂志,A辑:纯化学与应用化学》2013,50(7):548-554
A series of IPN based on poly(antimony acrylate) and poly(arsenic acrylate) have been synthesized by a sequential mode of synthesis. Formation of complex based on “polymer solvent” method reflects the contraction of the polymer coils by determining the value of mutual interaction constant (kAB) in different solvents such as dimethylsulphoxide (DMSO) (kAB=0.60); dimethylformamide (DMF) (kAB=0.42); dioxane (kAB=0.26) predicting weak Vander Waal interaction. The scanning electron microscopy reveals dual phase morphology of both metal acrylates. The infrared spectrum indicates characteristic frequencies of (>C?O) at 1730 cm?1,thus giving structural evidence for IPN. The properties namely percentage swelling, average molecular weight between crosslinks(Mc),Young's modulus, increases with concentrations of linear polymer(polyantimony acrylate) and initiator (benzoyl peroxide). However, it decreases with concentrations of monomer (arsenic acrylate) and crosslinker (divinyl benzene).The value of activation energy calculated from thermo gravimetric analysis is 15 KJ/mol. 相似文献
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Paola Mura Gian Piero Bettinetti Maria Teresa Faucci Milena Sorrenti Alessandra Negri 《Supramolecular chemistry》2013,25(4):379-389
Abstract Interactions of naproxen (NAP) with amorphous, randomly methylated β-cyclodextrin at a degree of substitution per anhydroglucose unit of 1.8 (RAMEB) and with crystalline heptakis-(2,6-di-O-methyl)-β-cyclodextrin (DIMEB) were studied in aqueous solution and in the solid state using, respectively, phase-solubility analysis (at 25 °C, 37 °C and 47 °C) and differential scanning calorimetry (DSC) supported by X-ray powder diffractometry. RAMEB and DIMEB displayed similar solubilizing and complexing abilities towards NAP, suggesting analogous inclusion modes of the drug in the host cavity in aqueous solution. Differences were instead observed in interactions in the solid state, where the amorphizing capacity of RAMEB toward NAP (evaluated by DSC) was about twice that of DIMEB at each drug-to-carrier ratio. Assuming that inclusion complexation is also involved in solid-state interactions, molecular modelling accounted for the experimental results in terms of structural features of DIMEB, i.e. the particular inwards orientation of O-6-C-8 groups of three alternate glucoses on the primary hydroxyl side which hampers a deep penetration of NAP in the DIMEB cavity in the solid state. On the contrary, no obstruction of the cavity apparently occurs with RAMEB due its noncrystalline state. The aqueous dissolution rate of NAP from NAP-RAMEB and NAP-DIMEB blends containing 0.59, 0.73, 0.85, and 0.92 mass fraction of carrier linearly increased at decreasing drug-to-carrier ratios. The improvement was 5 to 20 times (from powders) and 50 to 200 times (from discs) the dissolution rate of NAP alone for both carrier. Therefore the choice of the amorphous RAMEB in pharmaceutical formulations can be recommended mainly for economic reasons, though the anhydrous and non-hygroscopic nature of crystalline DIMEB might be of particular advantage in case of moisture sensitive formulations. 相似文献
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Geul Bang Chulhyun Lee Jung‐Rae Rho Young Hwan Kim 《Journal of mass spectrometry : JMS》2013,48(2):164-171
Ten ceramides and four cerebrosides were extracted from the starfish Distolasterias nipon by solvent extraction, silica gel column chromatography and reversed‐phase high‐performance liquid chromatography. Structural identification was conducted using tandem mass spectrometry of monosodiated ions desorbed by fast atom bombardment. The complete structures of four cerebrosides were determined by a previously reported method. The high‐energy collision‐induced dissociation (CID) spectral characteristics of ceramides with various structures depend on the number and positions of double bonds on both the N‐acyl and sphingoid chains, the presence of a hydroxyl group or a double bond at the C‐4 position of the sphingoid chain and the presence of an α‐hydroxy group on the N‐acyl chain. The high‐energy CID of the monosodiated ion, [M+Na]+, of each ceramide molecular species generated abundant ions, providing information on the composition of the fatty acyl chains and sphingoid long‐chain bases. Each homologous ion series along the fatty acyl group and aliphatic chain of the sphingoid base was used for locating the double‐bond positions of both chains and hydroxyl groups on the sphingoid base chain. The double‐bond positions were also confirmed by the m/z values of abundant allylic even‐ and odd‐electron ions, and the intensity ratio of the T ion peak relative to the O ion peak. This technique could determine the complete structures of ceramides and cerebrosides in an extract mixture and has great potential for determining other sphingolipids isolated from various biological sources. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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Thomas Waldmann Jens Klein Prof. Dr. Harry E. Hoster Prof. Dr. R. Jürgen Behm 《Chemphyschem》2013,14(1):162-169
Investigating the dynamics in an adlayer of the oligopyridine derivative 2‐phenyl‐4,6‐bis(6‐(pyridine‐2‐yl)‐4‐(pyridine‐4‐yl)pyridine‐2‐yl)pyrimidine (2,4′‐BTP) on Ag(111) by fast scanning tunneling microscopy (video‐STM), we found that rotating 2,4′‐BTP adsorbates coexist in a two‐dimensional (2D) liquid phase (β‐phase) in a dynamic equilibrium with static adsorbate molecules. Furthermore, exchange between an ordered phase (α‐phase) and β‐phase leads to fluctuations of the domain boundary on a time scale of seconds. Quantitative evaluation of the temperature‐dependent equilibrium between rotating and static adsorbates, evaluated from a large number of STM images, gains insight into energetic and entropic stabilization and underlines that the rotating adsorbate molecules are stabilized by an entropy contribution, which is compatible with that derived by using statistical mechanics. The general validity of the concept of entropic stabilization of rotating admolecules, favoring rotation already at room temperature, is tested for other typical small, mid‐size and large adsorbates. 相似文献