液体物性对雾化射流液雾粒径的影响

对不同液体在空气中湍动雾化射流的气液两相流场进行了数值模拟.建立了一次雾化的一维模型,分析了粘度、表面张力和气液质量流量比对液雾粒径的影响趋势,采用基于粒子追踪法的二次雾化三维模型,分析了物性和各种工况对液雾粒径沿轴向分布的影响程度.计算结果和已公开发表的实验数据进行比对,得到了较好的吻合,在此基础上,分析了影响气泡雾化喷嘴雾化质量的主要因素.     

Three-way Resolution of the Overlapping Ultrahigh-performance Liquid Spectrochromatograms for the Analysis of a Quaternary Mixture Using Parallel Factor Analysis

This paper presents a new application of three-way parallel factor analysis (3W-PARAFAC) model to the coeluting spectrochromatograms for the quantitative resolution of a quaternary mixture system consisting of paracetamol, propyphenazone, and caffeine with aspirin as an internal standard. Spectrochromatograms of calibration standards, validation sets, and unknown samples were recorded as a function of retention time and wavelength in the range of 0.0–2.5?min and 200–400?nm, respectively, using ultra-performance liquid chromatography with photodiode array detection (UPLC-PDA). Three-way UPLC-PDA data array X (retention time?×?wavelength?×?sample) was obtained from the data matrices of the spectrochromatograms. 3W-PARAFAC decomposition of three-way UPLC-PDA data array provided three loading matrices corresponding to chromatographic mode, spectral mode, and relative concentration mode. Quantitative estimation of paracetamol, propyphenazone, and caffeine in analyzed samples was accomplished using the relative concentration mode obtained by the deconvolution of the UPLC-PDA data set. The validity and ability of 3W-PARAFAC model were checked by analyzing independent test samples. It was observed from analyses that 3W-PARAFAC method has potential to uniquely resolve strongly overlapping peaks of analyzed compounds in a spectrochromatogram, which was obtained under experimental conditions consisting of the lower flow rate, short run time, and simple mobile phase composition. The proposed three-way chemometric approach was successfully applied to the simultaneous quantification of paracetamol, propyphenazone, and caffeine in tablets. Experiments showed that the determination results were in good agreement with label amount in commercial pharmaceutical preparation.     

High‐Throughput Synthetic Chemistry Enabled by Organic Solvent Disintegrating Tablet

Synthetic chemistry remains a time‐ and labor‐intensive process of inherent hazardous nature. Our organic solvent disintegrating tablet (O‐Tab) technology has shown potential to make industrial/synthetic chemistry more efficient. As is the case with pharmaceutical tablets, our reagent‐containing O‐Tabs are mechanically strong, but disintegrate rapidly when in contact with reaction media (organic solvents). For O‐Tabs containing sensitive chemicals, they can be further coated to insulate them from air and moisture.     

泡腾辅助液相微萃取/高效液相色谱法检测蜂蜜中7种喹诺酮类药物

以密度小于水且具有可切换亲水性的壬酸作为萃取剂,通过加入Na2CO3和H2SO4改变溶液pH值,使壬酸完成从疏水性到亲水性再到疏水性的转换,同时利用原位产生的CO2鼓泡加大接触面积,完成对分析物的萃取,建立了基于可切换亲水性溶剂的泡腾辅助液相微萃取（EA－LPME－SHS）/高效液相色谱－荧光检测法（HPLC－FLD）测定蜂蜜中7种喹诺酮类药物（QNs）的分析方法。最佳提取条件如下：萃取剂为200 μL壬酸;pH调节剂为400 μL 2.0 mol/L Na2CO3和300 μL 2.0 mol/L H2SO4;提取时间为1.5 min。结果表明,5种喹诺酮类药物在2.0～200 μg/L范围内呈良好线性（诺氟沙星和环丙沙星为2.0～100 μg/L）,相关系数（r2）为0.999 5～0.999 9;在10、100、500 ng/g加标水平下,7种待测药物的回收率为62.8%～117%,日内（n = 3）和日间（n = 6）相对标准偏差（RSD）不大于6.2%,检出限为3.0 ng/g,定量下限为10 ng/g。该方法的提取过程均在注射器内完成,无需离心即可实现相分离,具有绿色环保、操作简便、省时等特点。     

The Analysis of Theophylline — Containing Pharmaceuticals by Room Temperature Phosphorescence

Abstract

A simple and specific technique is used in analyzing pharmaceutical preparations (capsules, elixirs, syrups, and tablets) for theophylline and related compounds. The procedure consists of dissolving (diluting) appropriate amounts of the preparations and standards in (with) a 1 M KI-water solution, spotting 5 μL of each resultant solution onto filter paper discs, determining the phosphorescence intensities at room temperature and comparing sample signal levels to those of standards. The quantities of active ingredients and standards used in the determinations ranged from 25 ng to 1 μg. The results indicate that room temperature phosphorescence is useful for analyzing pharmaceutical preparations where active ingredients are usually contained in a wide variety of matrices.     

Enhancement of Sensitivity for Antimony Determination in Atomic Absorption Spectrophotometry by Introducing Stibine into an Argon-Hydrogen Flame

Abstract

The sensitivity of antimony determination with atomic absorption spectrophotometry is enhanced to a large extent by introducing stibine gas into an argon-hydrogen flame. As a reducing agent, zinc tablet made from the zinc powder paste with water is successfully used for quantitative and rapid productions of stibine from antimony (III) solution. The sensitivity for 1% absorption of the signal is estimated to be about 0.004 ppm of antimony.     

联立方程组新解法测定面康净片中两组分含量

采用联立方程组新解法不经提取分离直接测定面康净片中甲硝唑和维生素Ｂ６的含量。甲硝唑和维生素Ｂ６的平均回收率和相对标准偏差分别是１０１．４％，０．９７％和１００．６％，１．３１％。方法简便、快速、准确。     

CPA-矩阵法测定舒尔芬片剂中两组分的含量

本文采用ＣＰＡ－矩阵法不经分离同时测定舒尔芬片剂中双氯芬酸钠和磷酸可待因的含量。计算程序用ＢＡＳＩＣ语言编制。双氯芬酸钠和磷酸可待因的平均回收率及ＲＳＤ分别为９９．８５％，０．４６％和９９．８０％，０．５０％。方法简便、快速。     

High performance liquid chromatographic analysis of dehydroepiandrosterone and its pharmaceutical tablet formulation

A rapid, sensitive and stability indicating high performance liquid chromatographic method was developed and validated for the analysis of dehydroepiandrosterone (DHEA) in pharmaceutical tablet formulation. The analysis was done on a Supelcosil C(18) column (25 cm x 4.6 mm i.d., 5 microm). The mobile phase consisted of methanol:sodium acetate buffer solution (5 g/L):acetic acid (500 mL/L), 57:42:1, v/v/v, adjusted to pH 5 at a flow rate of 1 mL/min. Detection was carried out at a wavelength of 258 nm. The polynomial regression data for the calibration curve showed good linear relationship in the concentration range of 0.2-1 mg/mL with r = 0.9996. The method was validated for precision, accuracy and recovery. The limit of detection was found to be 50 ng/ microL. The method was applied for the analysis of DHEA in its pharmaceutical tablet formulation. The effects of different buffers and alcohols on the retention of DHEA were studied and the role of acetic acid as an organic phase modifier was also investigated.     

薄层扫描法测定利喉乐含片中没食子酸的含量

应用薄层扫描法测定了利喉乐含片中没食子酸的含量。以甲苯－醋酸乙酯－甲酸（Ｖ甲苯∶Ｖ醋酸乙酯∶Ｖ甲酸＝３∶５．４∶０．６）为展开剂,１０ｇ／ＬＦｅＣｌ３显色后,用Ｃｓ－９２０薄层扫描仪扫描,扫描波长为５２０ｎｍ。没食子酸在１．２４～６．２０μｇ之间线性关系良好,该法的加样回收率为９５．９３％,板内精密度为２．７８％,板间精密度为３．３０％,为利喉乐含片的质量控制提供了一种简便而准确的含量测定方法