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11.
三维荧光二阶校正法用于血浆和尿液中柔红霉素的快速测定 总被引:3,自引:2,他引:1
文章采用三维激发发射荧光光谱与化学计量学交替三线性分解(ATLD)二阶校正法相结合,对血浆液和尿液中柔红霉素(DM)进行定量测定。实验不需对血浆和尿液预测样进行萃取等分离预处理,选取激发波长410~530nm,发射波长550~650nm,分别每隔5nm取一个数据,利用激发发射荧光扫描分别获得两个三维响应数阵(大小为21×25×12)。当组分数选择为3时,血浆和尿液校正集中盐酸柔红霉素的相对浓度与实际浓度的相关系数分别为r1=0.9990和r2=0.9952,经ATLD算法解析得到的血浆和尿液预测样中柔红霉素平均回收率分别为(92.8±7.6)%和(94.7±4.4)%。实验结果表明,此法能够解决血浆和尿液中盐酸柔红霉素药物因血浆和尿液内源物质与分析物光谱重叠所引起的难分辨的问题,可用于未知干扰共存下柔红霉素的直接快速定量测定。 相似文献
12.
Xu Feng LIN Cheng MA* Yan Guang WANG Department of Chemistry Zhejiang University Hangzhou 《中国化学快报》2001,(8)
The anthracycline antibiotics, such as daunomycin 1 and doxorubicin 2, have attracted considerable interest because of their great therapeutic value in treating a number of human cancers. However, their use has been limited by a number of toxic and undesirable side effects and this stimulated the search for new anthracyclines with improved pharmacological profiles1,2,3. In our group, nitroxy radicals were first introduced to the sugar moieties of 1 and 2, and some exhibited significant antitum… 相似文献
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Shu Jia ZHANG* Yan Guang WANG* Ju Biao LI Department of Chemistry Zhejiang University Hangzhou 《中国化学快报》2001,(6)
The anthracycline antibiotics daunomycin 1 is clinically useful antineoplastic agents, with a broad spectrum of activity. However, it is hampered by a number of undesirable side effects, especially serious cardiotoxicity and this stimulated the search for new anthracyclines with improved pharmacological profiles1-3. In our group, nitroxy radicals were first introduced to daunomycin and two spin labeled daunomycin derivatives have been reported recently4. Now we reported other three new spin la… 相似文献