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11.
本文以循环伏安、光谱电化学和原子力显微镜方法从DNA角度研究柔红霉素与天然鱼精DNA和热变性DNA之间相互作用的机理。并对柔红霉素与鱼精DNA和热变性DNA复合物的组成及复合物的形成常数作了测定。研究发现嵌入作用是柔红霉素和天然DNA之间的主要作用方式;并且柔红霉素和天然DNA之间的作用要强于和热变性单链DNA之间的作用。对这两种复合物的光谱电化学和原子力显微镜研究表明,在体内氧化还原代谢条件下,柔红霉素还原过程中产生的半醌自由基可引发自由基链反应,造成DNA链的解链、断裂等损伤。 相似文献
12.
Shu Jia ZHANG* Yan Guang WANG* Ju Biao LI Department of Chemistry Zhejiang University Hangzhou 《中国化学快报》2001,(6)
The anthracycline antibiotics daunomycin 1 is clinically useful antineoplastic agents, with a broad spectrum of activity. However, it is hampered by a number of undesirable side effects, especially serious cardiotoxicity and this stimulated the search for new anthracyclines with improved pharmacological profiles1-3. In our group, nitroxy radicals were first introduced to daunomycin and two spin labeled daunomycin derivatives have been reported recently4. Now we reported other three new spin la… 相似文献
13.
Xu Feng LIN Cheng MA* Yan Guang WANG Department of Chemistry Zhejiang University Hangzhou 《中国化学快报》2001,(8)
The anthracycline antibiotics, such as daunomycin 1 and doxorubicin 2, have attracted considerable interest because of their great therapeutic value in treating a number of human cancers. However, their use has been limited by a number of toxic and undesirable side effects and this stimulated the search for new anthracyclines with improved pharmacological profiles1,2,3. In our group, nitroxy radicals were first introduced to the sugar moieties of 1 and 2, and some exhibited significant antitum… 相似文献
14.
This paper describes the largest H/D kinetic isotope effect (KIE) at room temperature (25 °C) reported to date (kH/kD=2400). In voltammetric measurements with DNA monolayers on gold electrodes, a maximum shift of −400 mV was recorded for the reduction peak potential of 50 μM hexammine cobalt(III) (CoHex) in 10 mM Tris buffer upon replacing water with deuterium oxide in the electrolyte. In subsequent comparative investigations, a much smaller shift (ca. −80 mV) was recorded with daunomycin, whereas no potential shift was recorded with hexammine ruthenium(III) (RuHex). The interactions of RuHex, CoHex, and daunomycin with a mixed self-assembled monolayer of single-stranded DNA and 6-mercapto-1-hexanol (ssDNA/MCH SAM) immobilized on gold electrodes were studied by using cyclic and differential-pulse voltammetry (CV and DPV, respectively). The hydrogen-bond network within the ssDNA layer seems to amplify the voltammetric H/D isotope effect with CoHex. Voltammetric studies of H/D isotope effects can provide a platform to investigate amplified isotope effects probably not only on DNA layers, but also on proteins and small organic molecules and may be useful for studies of cell proliferation as well as drug testing. 相似文献