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161.
Rhodium‐Catalyzed Arylation of Cyclopropenes Based on Asymmetric Direct Functionalization of Three‐Membered Carbocycles
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Dr. Longyang Dian Prof. Dr. Ilan Marek 《Angewandte Chemie (International ed. in English)》2018,57(14):3682-3686
A variety of highly diastereo‐ and enantiomerically enriched arylcyclopropanes is obtained through the asymmetric rhodium‐catalyzed arylation reaction of achiral nonfunctionalized cyclopropene derivatives with commercially available aryl boronic acids in the presence of (R,S)‐Josiphos. 相似文献
162.
Lewis Base‐Promoted Ring‐Opening 1,3‐Dioxygenation of Unactivated Cyclopropanes Using a Hypervalent Iodine Reagent
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Matthew H. Gieuw Dr. Zhihai Ke Prof. Dr. Ying‐Yeung Yeung 《Angewandte Chemie (International ed. in English)》2018,57(14):3782-3786
A facile and effective system has been developed for the regio‐ and chemoselective ring‐opening/electrophilic functionalization of cyclopropanes through C?C bond activation by [bis(trifluoroacetoxy)iodo]benzene with the aid of the Lewis basic promoter p‐toluenesulfonamide. The p‐toluenesulfonamide‐promoted system works well for a wide range of cyclopropanes, resulting in the formation of 1,3‐diol products in good yields and regioselectivity. 相似文献
163.
164.
Denis D. Borisov Dr. Roman A. Novikov Prof. Dr. Yury V. Tomilov 《Angewandte Chemie (International ed. in English)》2016,55(40):12233-12237
A new strategy for cascade assembly of substituted indenes and polycyclic lactones based on reactions of donor–acceptor cyclopropanes and styrylmalonates with aromatic aldehydes in the presence of GaCl3 has been developed. The use of GaCl3 makes it possible to principally change the direction of the reaction known in this series of substrates and to perform the process in a multicomponent version. Generation of formal 1,2‐zwitterionic intermediates owing to complexation of dicarboxylate groups with GaCl3 is the driving force of the reactions discovered. This method makes it possible to assemble indenylmalonates or indano[1′,2′:2,3]indano[2,1‐b]furan‐2‐ones in one synthetic stage from readily available starting compounds with high regio‐ and diastereoselectivity. A mechanism of the reactions has been suggested using the 18O label in benzaldehyde. 相似文献
165.
Divergent Reactivity of Thioalkynes in Lewis Acid Catalyzed Annulations with Donor–Acceptor Cyclopropanes
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Sophie Racine Bence Hegedüs Dr. Rosario Scopelliti Prof. Dr. Jérôme Waser 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(34):11997-12001
Efficient methods for the convergent synthesis of (poly)cyclic scaffolds are urgently needed in synthetic and medicinal chemistry. Herein, we describe new annulation reactions of thioalkynes with phthalimide‐substituted donor–acceptor cyclopropanes, which gave access to highly substituted cyclopentenes and polycyclic ring systems. With silyl‐thioalkynes, the Lewis acid catalyzed [3+2] annulation reaction with donor–acceptor cyclopropanes took place to afford 1‐thio‐cyclopenten‐3‐amines. On the other hand, an unprecedented polycyclic compound was formed with alkyl‐thioalkynes through a reaction pathway directly involving the phthalimide group. The two transformations proceeded in good yields and tolerated a large variety of functional groups. 相似文献
166.
Prof. Dr. J. Stephen Clark Filippo Romiti Kirsten F. Hogg Dr. Malai Haniti S. A. Hamid Sven C. Richter Dr. Alistair Boyer Joanna C. Redman Dr. Louis J. Farrugia 《Angewandte Chemie (International ed. in English)》2015,54(19):5744-5747
Chloroacetic acid promotes an efficient and diastereoselective intramolecular cascade reaction of electron‐deficient ynenones to deliver products featuring a 2,3,5‐trisubstituted furan bearing a fused cyclopropyl substituent at the 5‐position. Synthetically relevant polycyclic building blocks featuring rings of various sizes and heteroatoms have been synthesized in high yield using this mild acid‐catalyzed reaction. 相似文献
167.
168.
Prashant A. Waske 《Tetrahedron》2005,61(43):10321-10330
Various ring-fused cyclopropyl silyl ethers with an benzylic, olefinic or acetylenic side chain have been synthesized. Upon oxidative photoinduced electron transfer (PET) the cyclopropane ring opens and forms a reactive β-keto radical, which undergoes intramolecular cyclization. In some cases we observed only formation of ring opened non-cyclized products. With olefinic side chain 5-exo-trig mode of cyclization rather than 6-endo-trig mode of cyclization takes place whereas in case of acetylenic side chain we observed 6-endo cyclization. 相似文献
169.
de Meijere A Becker H Stolle A Kozhushkov SI Bes MT Salaün J Noltemeyer M 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(8):2471-2482
The trimethylsilyl-protected enynes 9a-c and 14a,b with alkynyl substituents on the three-membered ring or on the double bond of a methylenecyclopropane or a bicyclopropylidene moiety were prepared in two steps from the alcohols 6a-c and 12a,b, respectively, by conversion to the iodides and their coupling with lithium (trimethylsilyl)acetylide (8) in 38-73% overall yields. The bicyclopropylidene derivative 9d was synthesized in 49% yield directly from bicyclopropylidene (3) by lithiation followed by coupling with (5-iodopent-1-ynyl)trimethylsilane (11). Enynes 9b-d were protiodesilylated by treatment with K2CO3 in methanol to give the corresponding unprotected enynes 10b-d in 53, 74 and 94% yield, respectively. Enynes 17a-c with a carbonyl group adjacent to the acetylenic moiety were synthesized from oxo derivatives 15a-c by Wittig olefination followed by coupling with 8 in 47, 18 and 12% overall yield, respectively. Pauson-Khand reactions of the methylenecyclopropane derivatives with a substituent on the ring (9a,b and 10a) as well as on the double bond (14a,b and their in situ prepared protiodesilylated analogues) proceeded smoothly by stirring of the corresponding enyne with [Co2(CO)8] in dichloromethane at ambient temperature followed by treatment of the formed complexes with trimethylamine N-oxide under an oxygen atmosphere at -78 degrees C to give tricyclic or spirocyclopropanated bicyclic enones 18a,b, 19a, 20a,b, 21a,b in good yields. Alkynylbicyclopropylidene derivatives 9c,d and 10c,d formed the corresponding cobalt complexes at -78 to -20 degrees C. Treatment of the latter with N-methylmorpholine N-oxide under an argon atmosphere at -20 degrees C gave the spirocyclopropanated tricyclic enones 18c, 19c and 18d in 31-45% yields. The structure of 19c was proved by X-ray crystal structure analysis. The cyclization of enynones 17a-c in MeCN at 80 degrees C gave the spirocyclopropanated bicyclic diketones 22a-c in 38-65% yields. Intramolecular PKRs of the enynes 25a,d with a chiral auxiliary adjacent to the triple bond gave the corresponding products 26a,d in 70 and 79% yield, respectively, as 5:1 and 8:1 mixtures of diastereomers, respectively. Addition of lithium dimethylcuprate or higher order cuprates to the double bond of the former furnished bridgehead-substituted bicyclo[3.3.0]octanones 27a-c in 57-86% yields. Protiodesilylation of 27a followed by acetal cleavage gave the enantiomerically pure spirocyclopropanated bicyclo[3.3.0]octanedione (1R,5R)- 29a with [alpha]D(20)=-148 (c=1.0 in CHCl3) in 55% overall yield. 相似文献