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Steven Murkli Jared Klemm Dr. Adam T. Brockett Michael Shuster Prof. Dr. Volker Briken Prof. Dr. Matthew R. Roesch Prof. Dr. Lyle Isaacs 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(9):3098-3105
We report investigations of the use of cucurbit[8]uril (CB[8]) macrocycles as an antidote to counteract the in vivo biological effects of phencyclidine. We investigate the binding of CB[8] and its derivative Me4CB[8] toward ten drugs of abuse ( 3 – 9 , 12 – 14 ) by a combination of 1H NMR spectroscopy and isothermal titration calorimetry in phosphate buffered water. We find that the cavity of CB[8] and Me4CB[8] are able to encapsulate the 1-amino-1-aryl-cyclohexane ring system of phencyclidine (PCP) and ketamine as well as the morphinan skeleton of morphine and hydromorphone with Kd values ≤50 nm . In vitro cytotoxicity (MTS metabolic and adenylate kinase cell death assays in HEK293 and HEPG2 cells) and in vivo maximum tolerated dose studies (Swiss Webster mice) which were performed for Me4CB[8] indicated good tolerability. The tightest host⋅guest pair (Me4CB[8]⋅PCP; Kd=2 nm ) was advanced to in vivo efficacy studies. The results of open field tests demonstrate that pretreatment of mice with Me4CB[8] prevents subsequent hyperlocomotion induction by PCP and also that treatment of animals previously dosed with PCP with Me4CB[8] significantly reduces the locomotion levels. 相似文献
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Three‐component framework of cucurbit[6]uril, 3‐(1‐methylimidazolium‐3‐yl)propane‐1‐sulfonate and boric acid has been constructed. The crystal structure reveals 1:2 host‐guest motif of cucurbit[6]uril and 3‐(1‐methyl‐imidazolium‐3‐yl)propane‐1‐sulfonate, demonstrating both cation binding of imidazolium moiety and anion binding of sulfonate moiety for the first time. Incorporation of dimeric boric acid facilitates the formation of metal‐free three‐dimensional framework. 相似文献
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Dr. Hao Chen Jin Zhang Dr. Qun Yu Yanru Chen Prof. Dr. Yebang Tan 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(43):9445-9448
Current drug delivery systems gain more functions with increased complexity. With the idea of less is more, we synthesized hexanoate-cucurbit[7]uril (CB[7]C5COONa) with multiple promising features for drug delivery. The hexanoate group integrates multiple functions. It endows CB[7]C5COONa extremely high solubility of over 600 mg mL−1 and well-defined pH-controlled release ability without sacrificing on the high binding affinity of CB[7] cavity. Based on the pH-controlled release ability, CB[7]C5COONa can be used for controlling the bioactivity of drug molecules. We anticipate that the strategy of function integration would be useful for the design of simple yet powerful drug delivery systems. 相似文献