In this paper,we consider a singular elliptic system with both concave non-linearities and critical Sobolev-Hardy growth terms in bounded domains.By means of variational methods,the multiplicity of positive solutions to this problem is obtained. 相似文献
Bombyx batryticatus, a protein-rich edible insect, is widely used as a traditional medicine in China. Several pharmacological studies have reported the anticancer activity of B. batryticatus extracts; however, the capacity of B. batryticatus extracts as immune potentiators for increasing the efficacy of cancer immunotherapy is still unverified. In the present study, we investigated the immunomodulatory role of B. batryticatus protein-rich extract (BBPE) in bone marrow-derived dendritic cells (BMDCs) and DC vaccine-immunized mice. BBPE-treated BMDCs displayed characteristics of mature immune status, including high expression of surface molecules (CD80, CD86, major histocompatibility complex (MHC)-I, and MHC-II), increased production of proinflammatory cytokines (tumor necrosis factor-α and interleukin-12p70), enhanced antigen-presenting ability, and reduced endocytosis. BBPE-treated BMDCs promoted naive CD4+ and CD8+ T-cell proliferation and activation. Furthermore, BBPE/ovalbumin (OVA)-pulsed DC-immunized mice showed a stronger OVA-specific multifunctional T-cell response in CD4+ and CD8+ T cells and a stronger Th1 antibody response than mice receiving differently treated DCs, which showed the enhanced protective effect against tumor growth in E.G7 tumor-bearing mice. Our data demonstrate that BBPE can be a novel immune potentiator for a DC-based vaccine in anticancer therapy. 相似文献
The article deals with the class consisting of non‐vanishing functions f that are analytic and univalent in such that the complement is a convex set, and the angle at ∞ is less than or equal to for some . Related to this class is the class of concave univalent mappings in , but this differs from with the standard normalization A number of properties of these classes are discussed which includes an easy proof of the coefficient conjecture for settled by Avkhadiev et al. 3 . Moreover, another interesting result connected with the Yamashita conjecture on Dirichlet finite integral for is also presented. 相似文献
Multivalent binding is a key for many critical biological processes and unique recognition and specificity in binding enables many of different glycans and proteins to work in a great harmony within the human body. In this study, the binding kinetics of synthetic glycopolypeptides to the dendritic cell lectin DC‐SIGN and their inhibition potential for DC‐SIGN interactions with the gp120 envelope glycoprotein of HIV‐1 (gp120) are investigated.
Computer-generated plans for radiation treatment sometimes involve an unnecessarily large number of gantry angles. Such plans are time consuming and expensive to administer because each distinct angle causes a delay while the gantry is repositioned. To address this issue, we consider an optimization model that generates minimum-support solutions to the treatment planning problem – that is, solutions involving a minimum number of gantry angles. This model is a polyhedral concave program, which is solved using a successive linearization algorithm based on work by Mangasarian [10]. 相似文献