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151.
152.
淫羊藿根与叶活性成分的分析和比较 总被引:8,自引:0,他引:8
采用细胞膜色谱法(CMC)筛选,并结合离体药理实验确定主要活性成分,利用高效液相色谱法分析比较了淫羊藿根与叶中的活性成分及其差异性.色谱条件为Kromasil ODS 柱(150 mm× 4.6 mm.I.D )流动相甲醇-水(70:30,V:V);检测波长270nm。筛选发现淫羊藿根中的两个有效成分YYH-214和YYH-216对血管有较强的舒张作用,表明活性成分在CMC模型体系中的保留特性与药理作用之间存在良好的相关性。在此色谱条件下淫羊藿叶未检测到这两种活性成分. 相似文献
153.
聚合物共混物脆韧转变性能研究 Ⅲ.分散相形态参数之间的关系 总被引:4,自引:2,他引:4
为了研究形态(特别是分散状态)对聚合物共混物韧性的影响,建立了准网络形态模型,定义了分散相分布系数(ξ,0<ξ1),并给出其物理意义,推导了基体层厚度的计算公式,研究了形态参数的变化对基体层厚度的影响.对于常见的无规形态,ξ≈1.对于准网络形态,ξ<1,并且不是常数.计算结果表明,减小ξ和分散相粒径及其分布、增大其体积分数有利于减小基体层厚度.从理论上证明了准网络形态比无规形态更有利于减小基体层厚度. 相似文献
154.
A capillary electrophoresis (CE) method was developed for the separation of heparin oligosaccharides compatible to study the interactions between the oligosaccharides and granulocyte-colony stimulating factor (G-CSF). Unfractionated heparin was eliminitively degraded to heparin oligosaccharides by an endolytic heparinase. The degraded smaller oligosaccharides (M(r) < 1000) were baseline-separated by CE under a 50 mM phosphate buffer (pH 9.0) in 10 min. Standard heparin disaccharides and larger oligosaccharides (1000 < M(r) < 8000) were all separated under optimized separation conditions. Compared with standard heparin disaccharides, smaller oligosaccharides contained one nonsulfated, two monosulfated, and two disulfated disaccharides, but trisulfated disaccharides were not found. The smaller oligosaccharides were also identified and molecular mass was deduced by electrospray ionization-mass spectrometry (ESI-MS). Furthermore, interactions between G-CSF and the oligosaccharides were studied by using capillary zone electrophoresis (CZE) under the above separation conditions. It was found that larger oligosaccharides could interact with G-CSF while smaller oligosaccharides were not observed to bind to G-CSF under the experimental conditions. In conclusion, the purified heparinase could selectively degrade heparin into oligosaccharides and the interaction between G-CSF and heparin was correlated with the chain length of heparin. 相似文献
155.
用硒与尿素化合,新生的由杂环有机硒所组成的Zs-93硒剂治疗移植性S180肉瘤,有显著的抑瘤作用(P<0.01),其作用表现出一定的剂量效应,以5μg/只小鼠为最适,抑瘤率达60.76%,治疗组小鼠的T细胞、SOD活性均有增强。 相似文献
156.
ZHU Zhi-cheng SUN Mei ZHANG Xing-yi LIU Ke-xiang SHI Dong-lei LI Jin-dong SU Ji-quan XU Yue-chi FU Xue-qi 《高等学校化学研究》2007,23(3):289-296
This study objective was to express and characterize the catalytic domain of the human T cell protein tyrosine phosphatase(△TC-PTP) and to study immunohistochemically the expression of △TC-PTP in human non-small cell lung cancers. △TC-PTP gene was PCR amplified with the cDNA of human TC-PTP as template, and cloned into the pT7 expression vector. The recombinant pT7-△TC-PTP was expressed in E. coli Rosetta ( DE3 ) host cells and puri- fied. The enzymatic characteristics of △TC-PTP including enzyme activity and kinetics assay were measured. The antiserum was prepared by immunizing rabbit with the purified recombinant △TC-PTP. Rabbit polyclonal antibody against △TC-PTP was purified by PVDF immobilized antigen affinity chromatography. Immunohistochemical staining of lung cancer tissues was performed with antibody against △TC-PTP protein. △TC-PTP gene was correctly cloned, expressed, and purified. The recombinant △TC-PTP had a highly catalytic activity of PTPase. Squamous cell lung carcinoma showed a significantly higher expression rate of △TC-PTP (76. 92%, 10/13 ) than adenocarcinoma (57.14%, 4/7) and normal lung tissue(20%, 1/5 ). This study represents the first demonstration that △TC-PTP is highly expressed in human squamous cell lung carcinomas. In addition, this study provides an important basis for further studying the biological function of TC-PTP and its relationship with lung carcinomas and other diseases. 相似文献
157.
The concentration fields, Nusselt number distributions along the electrode, and ratios of concentrations of electrochemically active components at the entrance into and exit out of an electrochemical cell are determined by numerical integration of the convective-diffusion equation for a broad range of rate constants of electrode reactions, Peclet numbers, and geometrical parameters of channels. Three regions of parameter values are revealed. At low reaction rates (K
l
< 0.5), mass transfer is completely determined by electrode kinetics; at high rates (K
l
> 20), it is completely determined by the diffusion in the gas phase; and in the intermediate region of values of K
l
it is necessary to allow for both the diffusion processes and the electrode reactions.Translated from Elektrokhimiya, Vol. 41, No. 3, 2005, pp. 317–324.Original Russian Text Copyright © 2005 by Ezin, Somov. 相似文献
158.
We optimized the hot water extraction of polysaccharides from the root of Henry wood betony (RHWPs) using a uniform test and explored their anti-tumor activities in vitro and in vivo. The optimal extraction conditions were as follows: 40 min extraction time, liquid/solid ratio 30 mL/g, 100 min soaking time, two extraction cycles, 100% ethanol concentration, and extraction temperature of 80 °C. The molecular weight distribution of RHWPs with MWs was 228,600 g/mol and 5001 g/mol. The IR spectrum further indicated that RHWPs are acidic polysaccharides containing pyranose and furan rings. The main monosaccharides found in RHWPs were mannose, ribose, l-rhamnose monohydrate, glucuronic acid, galacturonic acid, glucose, galactose, xylose, arabinose, and fucose. RHWPs inhibited the proliferation of S180 tumor cells and induced apoptosis in vitro. Oral administration of RHWPs to tumor-bearing mice significantly inhibited the growth of the S180 xenografts, accelerated apoptosis in tumor cells, and expanded the necrotic regions. Furthermore, RHWPs also markedly increased the levels of TNF-α, IFN-γ, and IL-2 in the sera of tumor-bearing mice, and activated immune cells such as lymphocytes, NK cells, and macrophages, thereby inducing tumor cell apoptosis. Taken together, RHWPs are a promising anti-tumor agent that ought to be explored further. 相似文献
159.
本文设计合成了一系列以咔唑(CZ)和吡咯并吡咯二酮(DPP)为基本结构单元的D-A结构的新型小分子材料,并对其进行了一系列的性能表征.合成的材料以咔唑作为给电子单元,吡咯并吡咯二酮作为吸电子单元,采用三键作为π桥,并引入4-氟苯基、4-氰基苯基和4-甲氧基苯基作为末端取代基团对材料进行修饰.其中材料CZBTDPPF和CZBTDPPO因分别具有1.85和1.79 eV的较窄带隙而分别获得了相对较高的的光电转化效率(1.97%和1.91%).由此可见,引入4-氟苯基和4-甲氧基苯基作为末端取代基团对于延长材料共轭结构、拓宽材料吸收从而实现材料光伏性能的提升具有重要的作用. 相似文献
160.
JiangBinXIA FuYouLI ShuMingYANG ChunHuiHUANG 《中国化学快报》2004,15(5):619-622
Composite nanoporous electrode SnO2/TiO2 was fabricated for the dye sensitized solar cell (DSSC) with N3 (Cis-Ru). After introducing of TiO2, the open-circuit photovoltage (Voc) was higher than that of the pure SnO2 electrode, while short-circuit photocurrent (Isc) was varied with the ratio of the TiO2. Appropriate content of the TiO2 can be beneficial to the efficiency of the solar cell, and it gives negative impact on the composite electrode when the content of TiO2 is higher. 相似文献