One-pot heterocyclic ring closure of 1,1′-bi-2-naphthol to 7H-dibenzo[c,g]carbazole

An operationally simple ring closure of racemic 1,1′-bi-2-naphthol (BINOL) yielded the heterocyclic aromatic compound 7H-dibenzo[c,g]carbazole (DBC). This one-pot method gave a good conversion and is suitable for gram-scale synthesis. DBC derivatives have high thermal durability, amorphous and crystalline structures with unique morphological properties, and semi-conducting behavior with potential applications in organic electronics.     

Synthesis and Crystal Structure of 3,6-Bis（4,4,4- trifluorobutane- 1,3-dione）-9-n-butylcarbazole

A novel bis（β-diketonate） derivate, 3,6-bis（4,4,4-trifluorobutane-1,3-dione）-9-n- butylcarbazole 1, was synthesized and structurally characterized by single-crystal X-ray diffrac- tion. The crystal belongs to the monoclinic system, space group P2 1/c with a = 10.961（6）, b = 22.942（13）, c = 9.408（6）A, α = 90, β = 109.663（9）, y = 90°, V = 2228（2）A^3, Z = 4, Dc = 1.489 g/cm^3, C24H19F6NO4, Mr = 499.40, F（000） = 1024 and μ = 0.134 mm^-1. The structure was refined to the final R = 0.0699 and wR = 0.1627 for 3744 independent reflections （Rint = 0.1288） and 1349 observed reflections （I 〉 2σ（I））. Compound 1 consists of carbazole unit and two terminal diketonate groups, in which carbazole and its two adjacent diketonate rings are almost coplanar. Moreover, compound 1 was characterized with IR, elemental analysis, IH NMR, MS, electronic absorption, and single-photon fluorescence.     

新型N-取代苯基-9-烷基-3-咔唑磺酰脲类化合物的合成及其抗肿瘤活性

以9-烷基咔唑为原料,经磺化、氯化和氨化反应制得9-烷基咔唑-3-磺酰胺(4a和4o);取代苯胺与三光气反应制得取代苯基异氰酸酯(6a~6n,6s,6Ⅳ);4分别与6经缩合反应合成了30个新型的N-取代苯基-9-烷基-3-咔唑磺酰脲类化合物(7a~7Ⅳ),其结构经1H NMR,IR和ESI-MS表征。对7进行了Cdc25B抑制活性筛选。结果表明,在用药浓度为20μg·m L-1时,其中12个化合物对Cdc25B具有良好的抑制活性,抑制率大于90%。     

咔唑与N-烷基咔唑光物理行为的差异

已知甲基、乙基咔唑等咔唑的衍生物与对位苯二甲酸二甲酯(DMTP)和邻位苯二甲酸二甲酯(DMP)可以形成激基复合物^[1],但是咔唑与DMTP或DMP相互作用时观察不到激基复合物的荧光。     

2-(4-咔唑-1-基-苯基)-1H-苯并咪唑的合成及其光学性质

以邻苯二胺与4-(咔唑-1-基)苯甲醛为原料,合成了一种新型苯并咪唑衍生物--2-(4-咔唑-1-基-苯基)-1H-苯并咪唑(2),其结构经¹H NMR, ¹³C NMR, MS（ESI), IR和元素分析表征。通过理论计算,结合UV-Vis和单光子荧光光谱研究了其光学性质,结果表明：2在二氯甲烷,乙酸乙酯,乙醇,乙腈和DMF中的λ_max均位于292 nm和330 nm 附近, λ_em分别为389 nm, 379 nm, 395 nm, 400 nm和390 nm。     

Fluorescence excitation spectra of jet-cooled carbazole complexes with monohydric alcohols

We have analyzed the fluorescence excitation spectra of carbazole complexes with a single molecule of methyl, deuterated methyl, ethyl, and propyl (1-propanol and 2-propanol) alcohols, cooled in a supersonic jet. We have determined the shifts in the fluorescence excitation spectra of the complexes relative to the frequency of the purely electronic transition of unbound carbazole. They occur as a result of formation of hydrogen bonds between the N-H group of the carbazole and the OH group of the alcohols. The frequencies of stretching vibrations of the hydrogen bonds with different alcohols vary within the range 150–157 cm⁻¹, while the frequencies of the bending vibrations vary in the range 21–22.9 cm⁻¹. From the shape of the rotational contours of the bands for the purely electronic and vibronic transitions of the complexes, we determined that they belonged to rotational conformers. We calculated the equilibrium configurations of the complexes in the ground state. __________ Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 74, No. 6, pp. 756–760, November–December, 2007.     

Amphiphilic copolymers with pendant ­carbazolylalkyl groups. ­Effect of polymer structure on ­retardation of self‐quenching

A series of amphiphilic polyanions containing (9‐carbazolyl)alkyl methacrylamide or acrylamide were prepared and their fluorescence properties were compared in organic and aqueous solution. In organic solution, all copolymers exhibited a monomer emission which decayed exponentially, indicating no self‐quenching. Decreasing the length of the methylene spacer in the side chain induced the spectral broadening and sharpening, depending on the carbazolyl content in the copolymer. This may be related to the interchromophore interactions and the mobility of chromophores. In H ₂O, by contrast, quenched fluorescence was observed for the copolymers. It should be however noted that acrylamide‐type of amphiphilic copolymers, poly(9‐carbazolylmethyl‐acrylamide‐co‐sodium 2‐acrylamido‐2‐methylpropanesulfonate), are the least quenched polymers among those reported so far. Copyright © 2001 John Wiley & Sons, Ltd.     

Investigation of 3-(carbazol-9-YL)-1,2-epithiopropane interaction with aromatic amines

In the reaction of 9-(2,3-epithiopropyl)-9H-carbazole with aromatic amines (aniline, 4-methoxy-, 4-methyl-, 4-fluoro-, 4-bromo-, 4-chloro-, 3-chloro-, 2-chloroaniline) and subsequent oxidation of the mixtures formed of propanethiols and disulfides with 25% H₂O₂ in basic solutions the respective disulfides have been synthesized. Carbazolyl-containing derivatives of the thiazolidine have been obtained.Published in Khimiya Geterotsiklicheskikh Soedinenii. No. 1, pp. 90–99, January, 2000.     

咔唑-降冰片二烯二元化合物的合成及其分子内光敏异构化反应

降冰片二烯和四环烷之间的价键异构是太阳能贮存研究中最有希望的体系之一。太阳光的辐射一般大于300nm,而降冰片二烯本身的吸收在230nm 左右,无法直接吸收太阳光。为了解决这一矛盾,人们通常从两方面来研究,一方面,是在降冰片二烯上引