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排序方式: 共有377条查询结果,搜索用时 15 毫秒
291.
292.
The amounts of tissue plasminogen activator (tPA) of culture supernatants, cell surfaces as well as intracellular spaces of the mouse keratinocytes cultured in calcium-free medium or in the presence of low or high calcium concentration medium were tested using enzyme-linked immunosorbent assay (ELISA). The results indicated that cultured keratinocytes could secrete tPA into extracellular space and respond to the addition of high calcium concentration with a time-dependent increase of tPA secretion, and the peak value of tPA secretion appeared after 24 h of keratinocytes culture. Furthermore, comparing the amount of tPA in culture supernatants with that in cell surfaces, it was found that after culture for 24 h, the secreted tPA could bind to the surfaces of the keratinocytes through the lysine sites within its molecule, and this process was enhanced by high calcium concentration. On the basis of these data we assumed that in mouse keratinocytes, tPA firstly secretes into extracellular space and then binds to the keratinocytes surface, and calcium regulates tPA secretion and its following binding to the surface of keratinocytes, which may correlate with the differentiation of keratinocytes. 相似文献
293.
In this paper, the process of ammonia borane (AB) hydrolysis generate H2 on the transition metal Fe@Co core-shell structure has been obtained. According to the different roles played by H2O molecules and the number of H2O molecules involved, there are three schemes of reaction paths. Route I does not involve the dissociation of H2O molecules and all H atoms come from AB. Moreover, the H2O molecule has no effect on the breaking of the BH bond or the NH bond. The reaction absorbs more heat during the formation of the second and third H2 molecules. Route II includes the dissociation of H2O molecules and the cleavage of BH or NH bonds, respectively, and the reaction shows a slight exotherm. Route III started from the break of the BN bond and obtained 3H2 molecules through the participation of different numbers of H2O molecules. After multiple comparative analyses, the optimal hydrolysis reaction path has been obtained, and the reaction process can proceed spontaneously at room temperature. 相似文献
294.
Carmen M. Andújar SánchezMa José Iglesias Isidro J. Pérez ÁlvarezFernando López Ortiz 《Tetrahedron letters》2003,44(46):8441-8444
Organophosphorus compounds containing nitroaryl and cyanoaryl groups have been prepared in good yield through nucleophilic aromatic substitution of hydrogen using α-lithiated phosphazenes and phosphine borane complexes as nucleophiles. In all cases, nearly exclusive replacement of the hydrogen in the para position with respect to the activating group has been observed. 相似文献
295.
Grant D.W. Anderson Malcolm L.H. Green Ino C. Vei 《Journal of organometallic chemistry》2004,689(24):4407-4419
Reactions between [Fe(η-C5H5)(MeCO)(CO)(L)], L = PPh3 (1), PMe3 (2), PPhMe2 (3), PCy3 (4), CO (5), and B(C6F5)3 give new complexes [Fe(η-C5H5){MeCOB(C6F5)3}(CO)(L)] L = PPh3 (7), PMe3 (8), PPhMe2 (9), PCy3 (10), CO (11), where B(C6F5)3 coordinates selectively to the O-acyl groups. Hydrolysis of 7 gives [Fe(η-C5H5){HOB(C6F5)3}(CO)(PPh3)] (6). The X-ray structures of 6, 8 and 11 have been determined. Calculations, using density functional theory, demonstrate that the charge transfer to the acyl group on Lewis acid coordination is more significant in the σ than the π system. Both effects lead to a lengthening of the acyl C-O bond thus π populations cannot be inferred from the distance changes. 相似文献
296.
标题化合物乙醇胺合三(2-呋喃基)硼烷C_(14)H_(16)BNO(Mr=273.10)的晶体属单斜晶系,空间群为P2_1/c,晶胞参数a=10.053(2),b=8.211(9),c=16.509(2),β=95.09°,V=1357.3(7),Z=4,D_c=1.33g/cm ̄3,μ(MoKα)=0.901cm ̄(-1)。结构的偏离因子R=0.045,R_w=0.049。结构测定表明,呋喃环对硼原子的π电子反馈导致B─C键长极明显地缩短。由此可解释呋喃环与硼成键时所特有的共生倾向。 相似文献
297.
298.
SHEN Zong-Xuan ZHANG Ya-Wen LU Jun XU Xue-Nong LU Cheng-RongSchool of Chemistry Chemical Engineering Suzhou University Suzhou Jiangsu China 《中国化学》1997,15(5):459-463
A new series of 1,3,2-oxazaborolidine catalysts substituted in position 4 by the (CH3)3C(CH2)n group (n=2, 3, 4, 5) were synthesized and applied to the borane reduction of prochi-ral ketones. The relationship between catalyst structure and enantioselectivity was discussed. 相似文献
299.
A new, high-yielding methodology for reducing hydrazones to hydrazines is described, which allows the synthesis of different mono-, di- and trisubstituted hydrazines. Moreover, the reduction step can be followed by an in situ reaction with a carboxylic acid making possible a ‘one-pot’ synthesis of trisubstituted hydrazides. The method is relatively general and, in principle, suitable for industrial applications. 相似文献
300.
Masaki Kita Kaori Konishi Tomoyuki Koyama Makoto Kitamura Daisuke Uemura 《Tetrahedron》2007,63(27):6241-6251
A 62-membered novel polyol macrolide with a molecular weight of 2859 mu, symbiodinolide, was isolated from the symbiotic dinoflagellate Symbiodinium sp. Symbiodinolide exhibited a potent voltage-dependent N-type Ca2+ channel-opening activity at 7 nM and immediately ruptured the tissue surface of the acoel flatworm Amphiscolops sp. at 2.5 μM. The planar structure of symbiodinolide was elucidated by spectroscopic analysis and chemical degradations including hydrolysis and ethenolysis using the second-generation Grubbs' catalyst. Symbiodinolide was found to be a structural congener of zooxanthellatoxins. The relative stereochemistries of C26-C32, C44-C51, and C64-C66 parts, and the absolute stereochemistries of C69-73, C83-C103, and C3′-C18′ parts in symbiodinolide were established. 相似文献