The Holographic Principle for Latent Molecular Properties

All information about all latent molecular properties, not exhibited by a given molecular structure but reproducibly exhibited by the same molecule in a different state or having a different conformation, is fully encoded in any nonzero volume of the non-degenerate ground state electron density.     

生物酶振荡器研究谷胱甘肽的抗氧化效应

组装了一种生物酶振荡器（Peroxidase-Oxidase Biochemical Oscillator） 的实验装置、建立了相应的实验方法,在此基础上得到单倍周期、四倍周期、混沌 等丰富的振荡图谱信息,并采用它作为“探针”,检测了谷胱甘肽（GSH）的抗氧 化效应,它可作为定量分析的基础,线性范围为9.38 * 10~(-7) ～ 7.50 * 10~(- 5) mol·L~(-1),探讨了某些可能的反应机理。     

生化芯片上的光纤消逝波吸收光度检测

生化芯片上探测器的总体性能将影响整个芯片分析系统的检出限、检测速度和适用范围等指标,是芯片分析系统的一个关键部分.针对生化芯片检测区的检测体积小、样品剂量少以及与生化芯片集成等特殊要求,设计了易于集成在芯片内的,用分光光度法对混合后液体的消逝波吸收光谱探测的方法.     

不同发育阶段大鼠NaF与血清生化和元素含量慢性反应的研究

不同日龄３批雄性大鼠饲氟浓度５３．２＊１０＾－６,实验３个月。结果表明,与同日龄正常对照组相比,杆、肾铝显著升高的断乳２周大鼠的血清钙,ＲＢＣ、Ｈｂ含量、红细胞平均血红蛋白量、全血锌,全血铁,骨钙,骨磷含量均出现显著变化。２８０日龄且的体重和全血磷受影响较为显著。     

NAMBU BRACKET FORMULATION OF NONLINEAR BIOCHEMICAL REACTIONS BEYOND ELEMENTARY MASS ACTION KINETICS

We develop a Nambu bracket formulation for a wide class of nonlinear biochemical reactions by exploiting previous work that focused on elementary biochemical mass action reactions. To this end, we consider general reaction mechanisms including for example enzyme kinetics. Furthermore, we go beyond elementary reactions and account for reactions involving stoichiometric coefficients different from unity. In particular, we show that the stoichiometric matrix of biochemical reactions can be expressed in terms of Nambu brackets. Finally, we solve the sign problem that arises in the context of coupled biochemical reactions.     

肝素抗凝血浆与血清中微量元素测定的对比分析

目的研究肝素抗凝血浆代替血清进行微量元素测定的可行性。方法选择2014年6月在汉川市人民医院接受生化检验的272例患者,采用Beckman DXC800型全自动生化分析仪,同时检测患者的肝素抗血浆和血清中锌(Zn)、铁(Fe)、铜(Cu)3种微量元素的浓度。结果肝素抗凝血浆锌、铁与血清中的锌、铁离子浓度比较无显著差异,差异无统计学意义(P0.05);血浆中铜离子的浓度明显低于血清中铜离子的检测值,差异有统计学意义(P0.05),但通过回归方程可以校正。结论肝素抗凝检测方法能够有效避开血液的凝固过程,在短时间内分离标本并检测,从而减少放置误差。但肝素抗凝血浆铜的检验还应进行回归校正。     

分子信标的构建及其应用研究进展

分子信标（molecular beacon,MB）是一种寡聚核苷酸荧光探针,其具有灵敏度高、特异性强、操作简单以及不必与未反应的探针分离即可实时检测等优点,在分子生物学和基因组学及分子医学等领域具有十分重要的应用价值。 本文介绍了近年来出现的各种新型分子信标的结构及工作原理,概述了分子信标技术在生命科学领域中的应用,展望了分子信标技术的发展趋势。     

Dynamic model and simulation of the platelets’ role in blood coagulation

In order to confirm which process is the most important in the blood coagulation cascade, a dynamic model on the function of platelets in blood coagulation is presented based on biochemical experiments. Based on qualitative analysis and mathematical simulation, a series of conclusions about the influence of the activation rate of factor VIII and factor IX on the generation of thrombin (IIa) are drawn. It is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coagulation cascade. The value is related to the binding constantd ₂ of the platelet. The stability of the equilibrium value is also related to the pro-coagulation stimulus. This article also evaluates the influence of the stimulus strength and the activated rate parameter of platelets on thrombin. The proportion of platelets activated at any given time is designatedc. To eachc, we obtain a maximum concentration of thrombin. It is evident that when the level of factor IX is below 1% of the normal level, the rate of thrombin generation reduces dramatically, resulting in severe bleeding tendency. The project supported by the Beijing Municipal Natural Sciences Foundation (3982005)     

物理学在促进农业发展中的作用

介绍了核技术、电磁学、光学、声学、离子束等物理学技术在农业上的应用和精确农业，指出了物理学各项技术可使农业获得更多的经济效益和生态效应，从而使农业得到持续的发展。     

生物化学反应中一类非线性系统极限环的存在惟一性

研究了生物化学反应中一类非线性系统，得到了该系统的环绕正奇点极限环的充分必要条件，并且证明了如果存在极限环，则必惟一。